scholarly journals Advances in Wheat and Pathogen Genomics: Implications for Disease Control

2018 ◽  
Vol 56 (1) ◽  
pp. 67-87 ◽  
Author(s):  
Beat Keller ◽  
Thomas Wicker ◽  
Simon G. Krattinger
Keyword(s):  
Disease Resistance ◽  
Molecular Level ◽  
Resistance Breeding ◽  
Wheat Breeding ◽  
The Past ◽  
Wheat Improvement ◽  
Disease Resistance Breeding ◽  
Near Future ◽  
New Cultivars ◽  
Made In

The gene pool of wheat and its wild and domesticated relatives contains a plethora of resistance genes that can be exploited to make wheat more resilient to pathogens. Only a few of these genes have been isolated and studied at the molecular level. In recent years, we have seen a shift from classical breeding to genomics-assisted breeding, which makes use of the enormous advancements in DNA sequencing and high-throughput molecular marker technologies for wheat improvement. These genomic advancements have the potential to transform wheat breeding in the near future and to significantly increase the speed and precision at which new cultivars can be bred. This review highlights the genomic improvements that have been made in wheat and its pathogens over the past years and discusses their implications for disease-resistance breeding.

In vitro Selection: A Candidate Approach for Disease Resistance Breeding in Fruit Crops

2010 ◽  
Vol 9 (8) ◽  
pp. 437-446 ◽  
Author(s):  
Ramesh Chandra ◽  
Madhu Kamle ◽  
Anju Bajpai ◽  
M. Muthukumar ◽  
Shahina Kalim
Keyword(s):  
Disease Resistance ◽  
In Vitro Selection ◽  
Resistance Breeding ◽  
Fruit Crops ◽  
Disease Resistance Breeding

scholarly journals DNA markers for disease resistance breeding in peas (Pisum sativum L.)

1997 ◽  
Vol 50 ◽  
pp. 314-315 ◽  
Author(s):  
G. Timmerman-Vaughan ◽  
A.C. Russell ◽  
A. Hill ◽  
T.J. Frew ◽  
B.J. Gilpin
Keyword(s):  
Disease Resistance ◽  
Pisum Sativum ◽  
Dna Markers ◽  
Resistance Breeding ◽  
Disease Resistance Breeding

scholarly journals Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature

2019 ◽  
Vol 8 (11) ◽  
pp. 1846 ◽  
Author(s):  
Taranto-Montemurro ◽  
Messineo ◽  
Wellman
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Muscle Activity ◽  
Upper Airway ◽  
Loop Gain ◽  
Arousal Threshold ◽  
The Past ◽  
Obstructive Sleep ◽  
Near Future ◽  
Made In

Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options. To date there is no approved pharmacotherapy for this disorder, but several attempts have been made in the past and are currently ongoing to find one. The recent identification of multiple endotypes underlying this disorder has oriented the pharmacological research towards tailored therapies targeting specific pathophysiological traits that contribute differently to cause OSA in each patient. In this review we retrospectively analyze the literature on OSA pharmacotherapy dividing the medications tested on the basis of the four main endotypes: anatomy, upper airway muscle activity, arousal threshold and ventilatory instability (loop gain). We show how recently introduced drugs for weight loss that modify upper airway anatomy may play an important role in the management of OSA in the near future, and promising results have been obtained with drugs that increase upper airway muscle activity during sleep and reduce loop gain. The lack of a medication that can effectively increase the arousal threshold makes this strategy less encouraging, although recent studies have shown that the use of certain sedatives do not worsen OSA severity and could actually improve patients’ sleep quality.

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