scholarly journals Digital Mammography Screening: Association between Detection Rate and Nuclear Grade of Ductal Carcinoma in Situ

Radiology ◽  
2014 ◽  
Vol 271 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Stefanie Weigel ◽  
Walter Heindel ◽  
Oliver Heidinger ◽  
Shoma Berkemeyer ◽  
Hans Werner Hense
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Digital Mammography ◽  
Mammography Screening ◽  
Carcinoma In Situ ◽  
Detection Rate ◽  
Ductal Carcinoma ◽  
Nuclear Grade

scholarly journals Digital Mammography Screening: Does Age Influence the Detection Rates of Low-, Intermediate-, and High-Grade Ductal Carcinoma in Situ?

Radiology ◽  
2016 ◽  
Vol 278 (3) ◽  
pp. 707-713 ◽  
Author(s):  
Stefanie Weigel ◽  
Hans W. Hense ◽  
Jan Heidrich ◽  
Shoma Berkemeyer ◽  
Walter Heindel ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Digital Mammography ◽  
Mammography Screening ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
High Grade ◽  
Detection Rates

scholarly journals Detection Rates of Ductal Carcinoma in Situ with Biennial Digital Mammography Screening: Radiologic Findings Support Pathologic Model of Tumor Progression

Radiology ◽  
2018 ◽  
Vol 286 (2) ◽  
pp. 424-432 ◽  
Author(s):  
Stefanie Weigel ◽  
Laura Khil ◽  
Hans-Werner Hense ◽  
Thomas Decker ◽  
Jürgen Wellmann ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Ductal Carcinoma In Situ ◽  
Digital Mammography ◽  
Mammography Screening ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Detection Rates ◽  
Radiologic Findings

scholarly journals Predictive factors for the presence of invasive components in patients diagnosed with ductal carcinoma in situ based on preoperative biopsy

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kwan Ho Lee ◽  
Jeong Woo Han ◽  
Eun Young Kim ◽  
Ji Sup Yun ◽  
Yong Lai Park ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Preoperative Diagnosis ◽  
Ductal Carcinoma ◽  
Univariate Analysis ◽  
Breast Mri ◽  
Nuclear Grade ◽  
Preoperative Biopsy ◽  
Areolar Complex

Abstract Background In patients diagnosed with ductal carcinoma in situ (DCIS) with needle biopsy before surgery, invasive component (IC) is often found in the postoperative tissue, which results in altered post-surgical care. However, there are no clinically available factors to predict IC, and few MRI studies are available for the detection of IC in DCIS patients. The purpose of this study was to evaluate which risk factors can predict IC preoperatively. Methods Patients with a DCIS diagnosis based on preoperative biopsy, who underwent breast surgery Kangbuk Samsung Hospital between Jan 2005 and June 2018, were retrospectively evaluated. Clinico-pathological and breast MRI factors were compared between DCIS and DCIS with IC in postsurgical specimens. Results Of the 431 patients with a preoperative diagnosis of DCIS, 34 (7.9%) showed IC during the postoperative pathological investigations, and 217 (50.3%) underwent breast MRI. Among MRI-related factors, Mass-like enhancement on MRI was the sole but significant predictor of IC (HR = 0.26, C.I. = 0.07–0.93, p = 0.038), while nipple-areolar complex invasion, enhancement peak and pattern were not statistically significant. Nuclear grade was the only significant predictor of IC in the analysis of other clinico-pathological factors (HR = 2.39, C.I. = 1.05–5.42, p = 0.038 in univariate analysis, HR = 2.86, C.I. = 1.14–7.14, p = 0.025 in multivariate analysis). Conclusions Mass-like enhancement on MRI and high nuclear grade were associated with IC in patients with preoperative diagnosis of DCIS. Considering the high sensitivity of breast MRI for IC, further evaluation of the predictive value of MRI in preoperative DCIS patients is desirable.

scholarly journals Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Judith-Anne W Chapman ◽  
Naomi A Miller ◽  
H Lavina A Lickley ◽  
Jin Qian ◽  
William A Christens-Barry ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Nuclear Grade

SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening

2006 ◽  
Vol 45 (5) ◽  
pp. 536-543 ◽  
Author(s):  
Stefan O. Emdin ◽  
Bengt Granstrand ◽  
Anita Ringberg ◽  
Kerstin Sandelin ◽  
Lars-Gunnar Arnesson ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Mammography Screening ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Randomised Trial

Significance of HER2/neu overexpression in pure ductal carcinoma in situ: A clinicopathologic study with long-term follow-up.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 85-85
Author(s):  
Zeina Al-Mansour ◽  
Thomas Stockl ◽  
Ashraf Khan ◽  
Richard Horner ◽  
Ediz Cosar ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Disease Recurrence ◽  
Nuclear Grade ◽  
Her2 Overexpression ◽  
Her2 Positive ◽  
High Nuclear Grade

85 Background: The prognostic value of HER2 (c-ERB2) overexpression in invasive breast cancer is well known, and correlates with aggressivene behavior. HER2 overexpression was reported in 13-56% of ductal carcinoma in-situ (DCIS). The significance of HER2 overexpression in DCIS has yet to be elucidated. The aim of this study was to correlate HER2 status with known prognostic indicators of DCIS and to evaluate whether the HER2 overexpression correlates with disease recurrence. Methods: All cases of DCIS diagnosed at our institution between 2000 and 2005 were retrieved. Cases without follow-up, those treated with mastectomy or those with concurrent invasive component were excluded. Clinicopathologic data were collected, including age at time of diagnosis, size of the lesion, nuclear grade, presence of comedo necrosis, margin status, estrogen (ER) and progesterone receptor (PR) status, type of adjuvant treatment received and length of follow-up. A representative block from each case was immunostained using the Hercept test. Slides were reviewed by 2 pathologists and interpreted in accordance with ASCO/CAP guidelines. Equivocal cases were reflexed for FISH testing. Results: A total of 152 cases were examined. Mean follow-up period was 77 months (range 12 to 138 months). HER2 was overexpressed in 49 cases (33%), and was significantly associated with high nuclear grade and presence of comedo necrosis. HER2-positive patients were more likely to be ER and PR negative. HER2 positive and negative patients did not differ significantly with respect to age at presentation or size of DCIS. On univariate analysis, HER2-type DCIS showed a higher risk of recurrence (P=0.037), however, this trend did not reach statistical signifance on multivariate analysis. Conclusions: HER2 overexpression was found to be associated with high nuclear grade, comedo necrosis as well as negativity for ER and PR but not with age or the size of DCIS. Patients with HER2-type DCIS (ER/PR-, HER2+) had a higher risk of disease recurrence than other types. However, after adjusting for all the other clinical variables, the molecular phenotype did not withhold its statistical significance as an independent predictor for recurrence.

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