Thermogenesis after a mixed meal: role of leg and splanchnic tissues in men and women

1995 ◽  
Vol 268 (3) ◽  
pp. E433-E438 ◽  
Author(s):  
M. D. Jensen ◽  
C. M. Johnson ◽  
P. E. Cryer ◽  
M. J. Murray
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Oxygen Uptake ◽  
Muscle Metabolism ◽  
Mixed Meal ◽  
Relative Contribution ◽  
Energy Needs ◽  
Consumption Rates ◽  
Postprandial Thermogenesis

To determine the relative contribution of splanchnic and leg tissues to postprandial thermogenesis, systemic and regional oxygen consumption rates were measured in nine women and eight men before and for 6 h after the consumption of a mixed meal that provided one-third of the daily energy needs. In women, the increase in splanchnic oxygen uptake accounted for 63 +/- 12% of the postprandial increase in oxygen consumption, whereas in men it accounted for 35 +/- 14% (P = not significant between women and men). Leg oxygen uptake accounted for 11 +/- 4 and 10 +/- 3% of the increase in postprandial oxygen consumption in women and men, respectively. The combined data suggest that approximately 48% of postprandial thermogenesis over 6 h occurs in splanchnic tissues, whereas 30-35% occurs in skeletal muscle. Thus the increase in oxygen consumption after a mixed meal is primarily localized to splanchnic tissues, and major reductions in postprandial thermogenesis are unlikely to be attributable solely to abnormalities of skeletal muscle metabolism.

scholarly journals Mitochondrial Fragmentation in Skeletal Muscle Derived Cells from an Old Male Donor May Relate to Decreased Oxygen Consumption Rates

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
José Adan Arevalo ◽  
Marvin L. Miller ◽  
José Pablo Vazquez-Medina ◽  
George A. Brooks
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Mitochondrial Fragmentation ◽  
Male Donor ◽  
Consumption Rates

Role of Bradycardia and Cold per se in Increasing Mechanical Efficiency of Hypothermic Heart

1958 ◽  
Vol 192 (2) ◽  
pp. 331-334 ◽  
Author(s):  
Henry Badeer ◽  
Avedis Khachadurian
Keyword(s):  
Cardiac Output ◽  
Oxygen Consumption ◽  
Oxygen Uptake ◽  
Arterial Pressure ◽  
Mechanical Efficiency ◽  
Metabolic Effect ◽  
Stroke Work ◽  
Per Se ◽  
Lung Preparation

The relative influence of bradycardia and of cold per se on the oxygen consumption and mechanical efficiency of the dog heart was investigated in the modified heart-lung preparation (11 experiments). Myocardial oxygen uptake was determined under constant arterial pressure and cardiac output in a) normothermia, b) normothermia with bradycardia induced by a cold thermode on the pacemaker, and c) hypothermia producing the same bradycardia as in ( b). At 36.8°C with a rate of 153 beats/min. the efficiency was 8.5% ± 0.3(S.E.), whereas with a rate of 110/min. efficiency was 9.1% ± 0.4(S.E.), a change that is statistically not significant. In hypothermia of 31.5°C with a rate of 110/min. the efficiency was 10.8% ± 0.3(S.E.), an increase that is statistically significant. Performing the same stroke work the hypothermic myocardium consumed less oxygen than the normothermic. It is concluded that the metabolic effect of cold per se is the chief factor responsible for increasing the mechanical efficiency of the hypothermic heart when pressure-volume work is kept constant.

scholarly journals The SCOC database, a large, open, and global database with sediment community oxygen consumption rates

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Tanja Stratmann ◽  
Karline Soetaert ◽  
Chih-Lin Wei ◽  
Yu-Shih Lin ◽  
Dick van Oevelen
Keyword(s):  
Oxygen Consumption ◽  
Oxygen Uptake ◽  
Selection Procedure ◽  
Ex Situ ◽  
Global Database ◽  
Data Record ◽  
Consumption Rates ◽  
Meta Analyses

Abstract Sediment community oxygen consumption (SCOC) rates provide important information about biogeochemical processes in marine sediments and the activity of benthic microorganisms and fauna. Therefore, several databases of SCOC data have been compiled since the mid-1990s. However, these earlier databases contained much less data records and were not freely available. Additionally, the databases were not transparent in their selection procedure, so that other researchers could not assess the quality of the data. Here, we present the largest, best documented, and freely available database of SCOC data compiled to date. The database is comprised of 3,540 georeferenced SCOC records from 230 studies that were selected following the procedure for systematic reviews and meta-analyses. Each data record states whether the oxygen consumption was measured ex situ or in situ, as total oxygen uptake, diffusive or advective oxygen uptake, and which measurement device was used. The database will be curated and updated annually to secure and maintain an up-to-date global database of SCOC data.

Force development and metabolism in skeletal muscle of euthyroid and hypothyroid rats

1981 ◽  
Vol 97 (2) ◽  
pp. 221-225 ◽  
Author(s):  
M. E. Everts ◽  
C. van Hardeveld ◽  
H. E. D. J. Ter Keurs ◽  
A. A. H. Kassenaar
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Muscle Metabolism ◽  
Glucose Consumption ◽  
Triceps Surae ◽  
Active Force ◽  
Muscle Preparation ◽  
Force Development ◽  
Contraction Process ◽  
Triceps Surae Muscles

Abstract. The effects of thyroid hormone depletion on skeletal muscle metabolism in relation to force development were studied. For this purpose, the triceps surae muscles were perfused and stimulated at 5 Hz. The basal oxygen consumption of the skeletal muscle preparation was 50% lower in hypothyroid rats as compared with euthyroid rats. The results show that: 1. Active force development was the same in euthyroid and hypothyroid rats during 30 min of stimulation. 2. The increase in oxygen consumption during contraction was twice as high in the euthyroid group compared with the hypothyroid group. 3. Lactate release and glucose consumption were considerably higher in the euthyroid group than in the hypothyroid group during the last 15 min of stimulation. The data show that force development is not impaired in hypothyroid rats but, on the contrary, indicate that the contraction process proceeds more economically in hypothyroid rats than in euthyroid rats.

Emerging role of neuregulin as a modulator of muscle metabolism

2010 ◽  
Vol 298 (4) ◽  
pp. E742-E750 ◽  
Author(s):  
Anna Gumà ◽  
Vicente Martínez-Redondo ◽  
Iliana López-Soldado ◽  
Carles Cantó ◽  
Antonio Zorzano
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Neuromuscular Junction ◽  
Muscle Contraction ◽  
Neurotrophic Factor ◽  
Muscle Metabolism ◽  
Metabolic Effects ◽  
Energetic Metabolism ◽  
Insulin Responsiveness

Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.

scholarly journals IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Laura Regué ◽  
Fei Ji ◽  
Daniel Flicker ◽  
Dana Kramer ◽  
William Pierce ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Growth Factor ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Wheel Running ◽  
Muscle Metabolism ◽  
Insulin Like Growth Factor ◽  
Voluntary Activity ◽  
Mouse Muscle

ABSTRACT Insulin-like growth factor 2 (IGF2) mRNA binding protein 2 (IMP2) was selectively deleted from adult mouse muscle; two phenotypes were observed: decreased accrual of skeletal muscle mass after weaning and reduced wheel-running activity but normal forced treadmill performance. Reduced wheel running occurs when mice are fed a high-fat diet but is normalized when mice consume standard chow. The two phenotypes are due to altered output from different IMP2 client mRNAs. The reduced fiber size of IMP2-deficient muscle is attributable, in part, to diminished autocrine Igf2 production; basal tyrosine phosphorylation of the insulin and IGF1 receptors is diminished, and Akt1 activation is selectively reduced. Gsk3α is disinhibited, and S536-phosphorylated ε subunit of eukaryotic initiation factor 2B [eIF2Bε(S536)] is hyperphosphorylated. Protein synthesis is reduced despite unaltered mTOR complex 1 activity. The diet-dependent reduction in voluntary exercise is likely due to altered muscle metabolism, as contractile function is normal. IMP2-deficient muscle exhibits reduced fatty acid oxidation, due to a reduced abundance of mRNA of peroxisome proliferator-activated receptor α (PPARα), an IMP2 client, and PPARα protein. IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose. The greater dependence on muscle glucose metabolism during increased oxygen demand may promote central fatigue and thereby diminish voluntary activity.

The role of carbonic anhydrase in the recovery of skeletal muscle from anoxia

2005 ◽  
Vol 99 (2) ◽  
pp. 488-498 ◽  
Author(s):  
Krzysztof Wroblewski ◽  
Simon Spalthoff ◽  
Un-Jin Zimmerman ◽  
Robert L. Post ◽  
Joseph W. Sanger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Carbonic Anhydrase ◽  
Muscle Metabolism ◽  
Carbonic Anhydrase Inhibitor ◽  
Newborn Rabbit ◽  
Rate Of Recovery ◽  
Late Recovery

To investigate the role of carbonic anhydrase in the recovery of skeletal muscle from anoxia, pH and cell phosphates were measured by 31P-nuclear magnetic resonance in superfused newborn rabbit myotubes and cultured mouse soleus cells (H-2Kb-ts a58) after ∼2–3.5 h without superfusion. In control studies, pH and phosphocreatine fell and Pi rose during anoxia and recovered within <10 min after reperfusion began. A carbonic anhydrase inhibitor, acetazolamide, and dimethylamiloride, an inhibitor of the Na+/H+ antiporter NHE1, delayed the recoveries of pH, phosphocreatine, and Pi for >10 min, but the rate of recovery, once initiated, was unchanged. In the presence of the inhibitors, after reperfusion started, the pH did not rise immediately, despite a large inwardly directed HCO3− gradient, suggesting that HCO3− movement was unimportant in acid elimination. Lactate, measured by its methyl protons, rose during anoxia and did not fall after 1 h of reperfusion and could not have eliminated protons by cotransport. We conclude that NHE1 is the major exporter of protons by skeletal muscle in recovery from a period of anoxia and that it is essential for functioning carbonic anhydrase to be attached to NHE1 to activate it. The mechanism of late recovery of pH could be the mobilization of another proton transporter or removal of the inhibition of the Na+/H+ antiporter. Inhibition of carbonic anhydrase in skeletal muscle retards acid removal and modifies muscle metabolism significantly after anoxia.

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