Cardiac effects of nucleosides after propranolol treatment of isolated hearts

1970 ◽  
Vol 218 (5) ◽  
pp. 1399-1405 ◽  
Author(s):  
NM Buckley
Keyword(s):  
Cardiac Effects ◽  
Isolated Hearts ◽  
Propranolol Treatment

Cardiogenic Hypertension: Experimental Evidence from a Comparison between Intravenous and Intracoronary Administration of Dobutamine in Conscious Dogs

1980 ◽  
Vol 58 (4) ◽  
pp. 271-277 ◽  
Author(s):  
J.-F. Liard
Keyword(s):  
Cardiac Output ◽  
Arterial Pressure ◽  
Peripheral Resistance ◽  
Electromagnetic Flowmeter ◽  
Conscious Dogs ◽  
Cardiac Effects ◽  
Intracoronary Administration ◽  
Haemodynamic Changes ◽  
Propranolol Treatment ◽  
Oral Propranolol

1. We have studied whether the progressive rise in peripheral resistance observed in response to chronic intracoronary administration of dobutamine in conscious dogs could have resulted from extracardiac or non-β-adrenergic cardiac effects of the drug. 2. Six conscious dogs received dobutamine, 1.56 × 10−8 mol min−1 kg−1, intravenously for a 7 day period and seven conscious dogs were given dobutamine, 1.51 × 10−8 mol min−1 kg−1, into the left coronary artery under oral propranolol treatment for the same period while arterial pressure, cardiac output (electromagnetic flowmeter) and heart rate were measured. 3. Intravenous dobutamine produced no increase in arterial pressure, but a decrease in peripheral resistance and an increase in cardiac output which persisted until the end of the infusion. 4. With propranolol treatment intracoronary dobutamine induced no significant haemodynamic changes but a short-lasting increase in mean arterial pressure and peripheral resistance. 5. It is concluded that β-adrenergic cardiac effects of dobutamine are essential to the development of hypertension and increased peripheral resistance after prolonged intracoronary infusion of this drug.

Comparative Cardiac Effects of KT-362 and Verapamil in Isolated Hearts—Correlation to Calcium Channel Current Depression

1991 ◽  
Vol 18 (4) ◽  
pp. 594-604 ◽  
Author(s):  
Nediljka Buljubasic ◽  
Jure Marijic ◽  
David F. Stowe ◽  
Garrett J. Gross ◽  
John P. Kampine ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Cardiac Effects ◽  
Isolated Hearts ◽  
Channel Current

Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum

2016 ◽  
Vol 35 ◽  
pp. 11-16 ◽  
Author(s):  
Katharina Neumaier ◽  
Franz Worek ◽  
Horst Thiermann ◽  
Timo Wille
Keyword(s):  
Smooth Muscle ◽  
Cardiac Effects ◽  
Isolated Hearts

The Antiaggressive Action of Combined Haloperidol-Propranolol Treatment in Schizophrenia

2000 ◽  
Vol 5 (4) ◽  
pp. 312-325 ◽  
Author(s):  
Gadi Maoz ◽  
Daniel Stein ◽  
Sorin Meged ◽  
Larisa Kurzman ◽  
Joseph Levine ◽  
...  
Keyword(s):  
Rating Scales ◽  
Double Blind ◽  
Propranolol Group ◽  
Schizophrenic Patients ◽  
Propranolol Treatment ◽  
Simultaneous Decrease ◽  
The Mean ◽  
Haloperidol Treatment ◽  
To Receive ◽  
Drug Free

Psychopharmacological interventions for managing aggression in schizophrenia have thus far yielded inconsistent results. This study evaluates the antiaggressive efficacy of combined haloperidol-propranolol treatment. Thirty-four newly admitted schizophrenic patients were studied in a controlled double-blind trial. Following a 3-day drug-free period and 7 days of haloperidol treatment, patients were randomly assigned to receive either haloperidol-propranolol or haloperidol-placebo for eight consecutive weeks. Doses of medications were adjusted as necessary; biperiden was administered if required. Rating scales were applied to assess aggression, anger, psychosis, depression, anxiety and extrapyramidal symptoms. The mean daily dose of haloperidol was 21 mg (SD = 6.4) in the research group and 29 mg (SD = 6.9) in the controls. Mean and maximal daily doses of propranolol were 159 mg (SD = 61) and 192 mg (SD = 83), and of placebo, 145 mg (SD = 50) and 180 mg (SD = 70), respectively. Compared with the controls, the scores for the research patients decreased significantly from baseline, particularly after 4 weeks of treatment, for some dimensions of anger, psychosis, anxiety, and neuroleptic-induced parkinsonism. A tendency for reduced aggression was shown in the combined haloperidol-propranolol group for some dimensions but not others. These patients also required significantly less biperiden. The tendency toward elevated antiaggressive effect of combined haloperidol-propranolol treatment compared to haloperidol alone may be explained by a simultaneous decrease in aggression, psychotic symptomatology, and anxiety.

scholarly journals Cardiac effects of activation of the parasympathetic ganglia in the third fat pad in dog hearts.

1999 ◽  
Vol 79 ◽  
pp. 100
Author(s):  
Tsuboi Masato ◽  
Furukawa Yasuyuki ◽  
Koichi Nakajima ◽  
Fumio Kurogouchi ◽  
Chiba Shigetoshi
Keyword(s):  
Fat Pad ◽  
Cardiac Effects ◽  
Parasympathetic Ganglia ◽  
The Third

scholarly journals Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Horacio Gomez-Acevedo ◽  
Yuemeng Dai ◽  
Graham Strub ◽  
Carrie Shawber ◽  
June K. Wu ◽  
...  
Keyword(s):  
Data Integration ◽  
Propranolol Treatment

scholarly journals Possible complication of bee stings and a review of the cardiac effects of bee stings

2016 ◽  
pp. bcr2015213974 ◽  
Author(s):  
Prabha Nini Gupta ◽  
B Krishna Kumar ◽  
Praveen Velappan ◽  
M D Sudheer
Keyword(s):  
Cardiac Effects
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