scholarly journals Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms

2016 ◽  
Vol 311 (2) ◽  
pp. F459-F468 ◽  
Author(s):  
Zachary C. Danziger ◽  
Warren M. Grill
Keyword(s):  
Estimation Procedure ◽  
Bladder Capacity ◽  
Bladder Function ◽  
Lower Urinary Tract Dysfunction ◽  
Linear Recurrence ◽  
Residual Volume ◽  
Postvoid Residual ◽  
Postvoid Residual Volume ◽  
Urodynamic Parameters

The postvoid residual volume (PVR) is a common urodynamic parameter used to quantify the severity of lower urinary tract dysfunction. However, the serial cystometrograms that are typically used to assess bladder function in animal models make measuring PVR very difficult. Current approaches are to either remove PVR after each void to measure it, which is disruptive to the bladder, or to neglect the unknown contribution to PVR from ureter flow, which results in inaccurate estimates. We propose a procedure to estimate PVR during a serial cystometrogram that requires only a single measurement, rather than measuring after each void. Moreover, this measurement can occur at the end of the experiment such that it does not affect the bladder during data collection. We mathematically express PVR for all voids during a serial cystometrogram using a linear recurrence equation and use this equation to build an estimation procedure for PVR. Using in vivo measurements in urethane anesthetized rats and computer simulations we show that the estimation procedure is at least as accurate in determining PVR as the traditional method of measuring PVR after each void. Furthermore, we demonstrate the adverse effects of repeated PVR measurements in a common animal model of cystitis. Using the proposed procedure can increase the efficiency and accuracy of determining PVR for a serial cystometrogram and is less disruptive to the system under study. This, in turn, allows the calculation of other urodynamic parameters that are critical for research studies, including voiding efficiency and bladder capacity.

Bladder dysfunction in women with diabetes mellitus

2019 ◽  
pp. 34-40
Author(s):  
Thi Bich Ngoc Hoang ◽  
Hai Thuy Nguyen
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Bladder Dysfunction ◽  
Clinical Symptoms ◽  
Residual Volume ◽  
Cross Sectional ◽  
Diabetic Cystopathy ◽  
Postvoid Residual ◽  
Postvoid Residual Volume

Introduction: Lower urinary tract dysfunctions secondary to type 2 DM are common, chronic and costly disorders. The incidence of diabetic bladder dysfunction was estimated range between 43% and 87% for type 1 and 25% for type 2 diabetes. Ultrasonography is an easy-to-use, fast, safe, non-invasive, painless, pleasant and valuable method of assessing Bladder Post-Void Residual Volume (PVR). Aim: To investigate prevalence of bladder dysfunction and its relation with risk factors, clinical features of diabetic cystopathy in women with diabetes, to identify the values predicting to have postvoid residual volume of the risk factors. Methods: A cross sectional descriptive study, a cohort of 84 female inpatients and outpatients with diabetes mellitus who were treated at Hue University of Medicine and Pharmacy Hospital from 08/2017 to 08/2019 and 84 healthy control subjects were enrolled, the patients were carried out clinical finding, taken blood tests, and estimated postvoid residual volume using 2D ultrasound. Results: the postvoid residual volume was presented in 67 cases (79.80%), the clinical symptoms of diabetic cystopathy were reported in 75% of women with diabetes. Blood glucose, HbA1c, clinical symptoms of diabetic cystopathy, postural hypotension and diabetic peripheral neuropathy were associated with postvoid residual volume. The HbA1c level had a great capability to predict who had postvoid residual volume, at HbA1c cutoff value of 9.1%, Se 65.67%, Sp 94.12%, AUC 0.811, p < 0.001. Conclusion: Bladder dysfunction made up a highly prevalent in women with poor glycemic control. Key words: bladder dysfunction, diabetic cystopathy, bladder postvoid residual volume (PVR)

scholarly journals Urinary bladder function in conscious rat pups: a developmental study

2012 ◽  
Vol 302 (12) ◽  
pp. F1563-F1568 ◽  
Author(s):  
Katarina Zvarova ◽  
Peter Zvara
Keyword(s):  
Age Groups ◽  
Bladder Capacity ◽  
Bladder Function ◽  
Developmental Study ◽  
Conscious Rat ◽  
Early Postnatal Development ◽  
Rat Pups ◽  
Age Related ◽  
Voiding Pattern ◽  
Urodynamic Parameters

Cystometric studies of bladder function in anesthetized neonatal rats have suggested specific changes in urodynamic parameters that coincide with the development of a mature bladder-to-bladder micturition reflex. Here, we used a conscious cystometry model that avoids the potentially confounding effects of anesthesia to characterize voiding patterns and urodynamic parameters during early postnatal development in healthy rat pups. Cystometry was performed on postnatal day (P)0, 3, 7, 14, and 21 rats with continuous intravesical instillation of NaCl via a bladder catheter. Micturition cycles were analyzed with respect to voiding pattern, nonvoiding contractions, infused volume, and basal, filling, threshold, and micturition pressures. Reproducible micturition patterns were obtained from all age groups. The time from stimulation to contraction was significantly longer ( P ≤ 0.001) in ≤1-wk-old rats (∼10 s) than that in older rats (∼3 s). An interrupted voiding pattern was observed in ≤10-day-old subgroups. Micturition pressure progressively increased with age (from 21.77 ± 1.92 cmH2O at P0 to 35.47 ± 1.28 cmH2O at P21, P ≤ 0.001), as did bladder capacity. Nonvoiding contractions were prominent in the P3 age group (amplitude: 4.6 ± 1.3 cmH2O, frequency: ∼4.0 events/100 s). At P7, the pattern of spontaneous contractions became altered, acquiring a volume-related character that persisted in a less prominent manner through P21. Bladder compliance increased with age, i.e., maturation. In conclusion, conscious cystometry in rat pups resulted in reproducible micturition cycles that yielded consistent data. Our results revealed immature voiding and prolonged micturition contractions during the first 10 neonatal days and provide evidence for age-related changes in urodynamic parameters.

Accuracy of Bladder Scanning in the Assessment of Postvoid Residual Volume

2009 ◽  
Vol 31 (6) ◽  
pp. 526-532 ◽  
Author(s):  
Ghadeer Al-Shaikh ◽  
Annick Larochelle ◽  
Craig E. Campbell ◽  
Joyce Schachter ◽  
Kevin Baker ◽  
...  
Keyword(s):  
Residual Volume ◽  
Postvoid Residual ◽  
Postvoid Residual Volume

Bladder Scans and Postvoid Residual Volume Measurement Improve Diagnostic Accuracy of Cauda Equina Syndrome

Spine ◽  
2019 ◽  
Vol 44 (18) ◽  
pp. 1303-1308 ◽  
Author(s):  
Muralidharan Venkatesan ◽  
Luigi Nasto ◽  
Magnum Tsegaye ◽  
Michael Grevitt
Keyword(s):  
Diagnostic Accuracy ◽  
Cauda Equina Syndrome ◽  
Cauda Equina ◽  
Volume Measurement ◽  
Residual Volume ◽  
Postvoid Residual ◽  
Postvoid Residual Volume

scholarly journals Urodynamic evaluation of patients with localized prostate cancer before and 4 months after robotic radical prostatectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dong Sup Lee ◽  
Seung-ju Lee
Keyword(s):  
Radical Prostatectomy ◽  
Outlet Obstruction ◽  
Maximum Flow ◽  
Bladder Capacity ◽  
Bladder Function ◽  
Detrusor Contraction ◽  
Bladder Compliance ◽  
Urethral Closure ◽  
Relative Change ◽  
Urodynamic Parameters

AbstractRadical prostatectomy can alter the anatomy of the urinary bladder. We aimed to evaluate bladder function before and 4 months after radical prostatectomy using the urodynamic test and overactive bladder (OAB) symptom score. Among 70 prospectively enrolled patients, 61 patients completed the study. In the urodynamic test, bladder capacity and compliance did not change, the frequency of involuntary detrusor contraction decreased, the maximum flow rate and bladder outlet obstruction index improved, and the maximum urethral closure pressure (MUCP) deteriorated. Further evaluation of urodynamic parameters according to changes in symptoms was made. Although change in bladder compliance was correlated with changes in OAB symptoms, not the relative change of bladder compliance but the relative change in the MUCP was reliable factor when OAB symptoms were deteriorated. In general, prostatectomy did not deteriorate the condition of the detrusor; rather, change in the MUCP could be responsible for postprostatectomy OAB.

1700 CLINICAL PREDICTORS AND SIGNIFICANCE OF POSTVOID RESIDUAL VOLUME IN DIABETIC WOMEN

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Ayesha Appa ◽  
Jeanette Brown ◽  
Leslee Subak ◽  
Stephen Van Den Eeden ◽  
David Thom ◽  
...  
Keyword(s):  
Residual Volume ◽  
Clinical Predictors ◽  
Postvoid Residual ◽  
Postvoid Residual Volume

scholarly journals Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide

2019 ◽  
Vol 316 (1) ◽  
pp. F113-F120 ◽  
Author(s):  
Francis M. Hughes ◽  
Stephanie J. Sexton ◽  
Patrick D. Ledig ◽  
Chloe E. Yun ◽  
Huixia Jin ◽  
...  
Keyword(s):  
Rat Model ◽  
Bladder Outlet Obstruction ◽  
Critical Role ◽  
Outlet Obstruction ◽  
Bladder Function ◽  
Postvoid Residual ◽  
Bladder Weight ◽  
Voided Volume ◽  
Postvoid Residual Volume ◽  
Control Sham

Bladder outlet obstruction (BOO) leads to progressive voiding dysfunction. Acutely, obstruction triggers inflammation that drives bladder dysfunction. Over time, inflammation leads to decreased bladder nerve density and increased fibrosis, responsible for eventual decompensation and irreversibility. We have previously shown that BOO triggers inflammation, reduced bladder nerve density and increased fibrosis via activation of the NLRP3 inflammasome in an acutely obstructed (12-day) rat model. However, as BOO progresses, the bladder may become decompensated with an increase in postvoid residual volume and decreased voiding efficiency. Currently, we have examined rat bladder function and nerve densities after chronic BOO to determine whether NLRP3 plays a role in the decompensation at this stage. Four groups were examined: control, sham-operated, BOO, or BOO+gly (glyburide; an NLRP3 inhibitor). After 42 days, bladder weight, inflammation (Evans blue), urodynamics, and nerve density were measured. BOO greatly enhanced bladder weights and inflammation, while inflammation was prevented by glyburide. Voiding pressures were increased, and flow rates decreased in BOO and BOO+gly groups, demonstrating physical obstruction. No difference in frequency or voided volume was detected. However, postvoid residual volumes were greatly increased in BOO rats while BOO+gly rats were not different than controls. Moreover, there was a dramatic decrease in voiding efficiency in the chronic BOO rats, which was prevented with glyburide treatment. Finally, a reduction in nerve density was apparent with BOO and attenuated with glyburide. Together the results suggest a critical role for NLRP3 in mediating bladder decompensation and nerve density during chronic BOO.

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