Determination of Pulmonary Diffusing Capacity From Carbon Monoxide Equilibration Curves

1958 ◽  
Vol 12 (2) ◽  
pp. 283-291 ◽  
Author(s):  
Benjamin Burrows ◽  
Paul V. Harper
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

Competitive inhibition of carbon monoxide transport: evidence against a carrier

1981 ◽  
Vol 50 (5) ◽  
pp. 1061-1064 ◽  
Author(s):  
D. Z. Rubin ◽  
D. Fujino ◽  
C. Mittman ◽  
S. M. Lewis
Keyword(s):  
Carbon Monoxide ◽  
Competitive Inhibition ◽  
Normal Adult ◽  
Gas Mixture ◽  
Diffusing Capacity ◽  
Constant Amount ◽  
Pulmonary Diffusing Capacity ◽  
Co Concentration ◽  
Carrier Molecule ◽  
Co Concentrations

The existence of a saturable carbon monoxide (CO) carrier in the lung remains controversial. The carrier hypothesis was invoked to explain data that indicated that pulmonary diffusing capacity for CO (DLCO) decreases with increasing CO concentration. To test this hypothesis, we measured DLCO in 14 normal adult subjects at three alveolar CO concentrations (60, 660, and 2,060 ppm). Each mixture contained a constant amount of labeled C18O (60 ppm) and a balance of unlabeled C16O. If a saturable carrier exists at increasing CO concentrations, the unlabeled CO would compete for most of the sites on the carrier molecule, effectively inhibiting the uptake of the labeled C18O. C18O diffusing capacities (mean +/- SD) for the three levels of CO were 34.9 +/- 5.6, 33.0 +/- 6.0, and 34.7 +/- 7.8. There were no significant differences (P greater than 0.2) among the three levels. In another group of subjects we repeated the study using a gas mixture containing 130 ppm C18O. No significant differences were found. As a result, we find no evidence to support a CO carrier hypothesis.

scholarly journals Effect of hyperlipidaemia on pulmonary diffusing capacity for carbon monoxide.

Thorax ◽  
1979 ◽  
Vol 34 (2) ◽  
pp. 265-268 ◽  
Author(s):  
M R Partridge ◽  
J M Hughes ◽  
G R Thompson
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

Effect of exercise on pulmonary diffusing capacity

1963 ◽  
Vol 18 (3) ◽  
pp. 447-456 ◽  
Author(s):  
G. M. Turino ◽  
E. H. Bergofsky ◽  
R. M. Goldring ◽  
A. P. Fishman
Keyword(s):  
Carbon Monoxide ◽  
Young Adults ◽  
Steady State ◽  
Body Position ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity ◽  
Graded Exercise ◽  
Normal Man ◽  
The Difference

The effect of graded exercise on the pulmonary diffusing capacity for both oxygen and carbon monoxide measured simultaneously was studied in healthy young adults by steady-state methods. Pulmonary diffusing capacity for oxygen increases progressively with increasing severity of exercise; it exceeds the DlCO at high levels of exercise by amounts greater than can be accounted for by the difference in diffusivity of the test gases. Diffusing capacity for carbon monoxide increases less than DlOO2 for comparable grades of exercise but no definite plateau value could be established. The supine or upright body position does not influence the values of either DlOO2 or DlCO during exercise. Diffusing capacity of the lung for oxygen does not limit the maximum levels of exercise which may be achieved by normal man. Submitted on August 6, 1962

Pulmonary Diffusing Capacity for Carbon Monoxide by Rebreathing in Awake Dogs

Respiration ◽  
1986 ◽  
Vol 50 (4) ◽  
pp. 279-285 ◽  
Author(s):  
Yuichi Ichinose ◽  
Pietro Scotto ◽  
Michael Meyer ◽  
Johannes Piiper
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

Gas chromatography and pulmonary diffusing capacity measurements

1965 ◽  
Vol 20 (6) ◽  
pp. 1359-1361 ◽  
Author(s):  
L. A. Danzer ◽  
K. L. Kearns ◽  
J. E. Cohn
Keyword(s):  
Gas Chromatography ◽  
Carbon Monoxide ◽  
Gas Analysis ◽  
Diffusing Capacity ◽  
Chromatographic System ◽  
Oxygen Determination ◽  
Pulmonary Diffusing Capacity ◽  
Low Levels ◽  
High Concentrations

A gas chromatographic system is described which accurately measures low levels of neon and carbon monoxide in high concentrations of oxygen. The system contains a special parallel column package used in conjunction with a venting valve. Accurate reproducible analyses for Ne, CO, CO2, O2 and N2 are obtained from a single 10-ml gas sample. respiratory gas analysis; carbon monoxide in oxygen, determination; neon in oxygen, determination Submitted on December 2, 1964

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