Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen

1997 ◽  
Vol 83 (2) ◽  
pp. 354-358 ◽  
Author(s):  
Marta I. Pablos ◽  
Russel J. Reiter ◽  
Jin-Ing Chuang ◽  
Genaro G. Ortiz ◽  
Juan M. Guerrero ◽  
...  

Pablos, Marta I., Russel J. Reiter, Jin-Ing Chuang, Genaro G. Ortiz, Juan M. Guerrero, Ewa Sewerynek, Maria T. Agapito, Daniela Melchiorri, Richard Lawrence, and Susan M. Deneke. Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. J. Appl. Physiol. 83(2): 354–358, 1997.—Hyperbaric oxygen exposure rapidly induces lipid peroxidation and cellular damage in a variety of organs. In this study, we demonstrate that the exposure of rats to 4 atmospheres of 100% oxygen for 90 min is associated with increased levels of lipid peroxidation products [malonaldehyde (MDA) and 4-hydroxyalkenals (4-HDA)] and with changes in the activities of two antioxidative enzymes [glutathione peroxidase (GPX) and glutathione reductase (GR)], as well as in the glutathione status in the lungs and in the brain. Products of lipid peroxidation increased after hyperbaric hyperoxia, both GPX and GR activities were decreased, and levels of total glutathione (reduced+oxidized) and glutathione disulfide (oxidized glutathione) increased in both lung and brain areas (cerebral cortex, hippocampus, hypothalamus, striatum, and cerebellum) but not in liver. When animals were injected with melatonin (10 mg/kg) immediately before the 90-min hyperbaric oxygen exposure, all measurements of oxidative damage were prevented and were similar to those in untreated control animals. Melatonin’s actions may be related to a variety of mechanisms, some of which remain to be identified, including its ability to directly scavenge free radicals and its induction of antioxidative enzymes via specific melatonin receptors.

Shock ◽  
2000 ◽  
Vol 13 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Francesco Imperatore ◽  
Giuseppina Costantino ◽  
Carlo Luongo ◽  
Emanuela Mazzon ◽  
...  

1999 ◽  
Vol 27 (Supplement) ◽  
pp. 160A
Author(s):  
Bjorn Gunnarsson ◽  
Alexandre T. Rotta ◽  
David M. Steinhorn

2020 ◽  
Vol 20 (7) ◽  
pp. 1010-1014 ◽  
Author(s):  
Dana Filatova ◽  
Christine Cherpak

Background: Hypersensitivity to nickel is a very common cause of allergic contact dermatitis since this metal is largely present in industrial and consumer products as well as in some commonly consumed foods, air, soil, and water. In nickel-sensitized individuals, a cell-mediated delayed hypersensitivity response results in contact to dermatitis due to mucous membranes coming in long-term contact with nickel-containing objects. This process involves the generation of reactive oxidative species and lipid peroxidation-induced oxidative damage. Immunologically, the involvement of T helper (h)-1 and Th-2 cells, as well as the reduced function of T regulatory cells, are of importance. The toxicity, mutagenicity, and carcinogenicity of nickel are attributed to the generation of reactive oxygen species and induction of oxidative damage via lipid peroxidation, which results in DNA damage. Objective: The aim of this research is to identify nutritionally actionable interventions that can intercept nickel-induced cell damage due to their antioxidant capacities. Conclusion: Nutritional interventions may be used to modulate immune dysregulation, thereby intercepting nickel-induced cellular damage. Among these nutritional interventions are a low-nickel diet and an antioxidant-rich diet that is sufficient in iron needed to minimize nickel absorption. These dietary approaches not only reduce the likelihood of nickel toxicity by minimizing nickel exposure but also help prevent oxidative damage by supplying the body with antioxidants that neutralize free radicals.


1987 ◽  
Vol 42 (2) ◽  
pp. 570-577
Author(s):  
Yoshihiro Mano ◽  
Chikashi Akiba ◽  
Naoshi Takano ◽  
Nobumasa Doi ◽  
Masaharu Shibayama ◽  
...  

2011 ◽  
Vol 112 (7) ◽  
pp. 2549-2556 ◽  
Author(s):  
Mirit Eynan ◽  
Dimitry Tsitlovsky ◽  
Liron Batit ◽  
Ayala Hochman ◽  
Nitzan Krinsky ◽  
...  

1998 ◽  
Vol 791 (1-2) ◽  
pp. 75-82 ◽  
Author(s):  
M Chavko ◽  
J.C Braisted ◽  
N.J Outsa ◽  
A.L Harabin

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