Strenuous exercise decreases the percentage of type 1 T cells in the circulation

2001 ◽  
Vol 91 (4) ◽  
pp. 1708-1712 ◽  
Author(s):  
Adam Steensberg ◽  
Anders Dyhr Toft ◽  
Helle Bruunsgaard ◽  
Marie Sandmand ◽  
Jens Halkjær-Kristensen ◽  
...  
Keyword(s):  
T Cells ◽  
Peak Plasma ◽  
Maximal Oxygen Consumption ◽  
Interferon Γ ◽  
Treadmill Running ◽  
Strenuous Exercise ◽  
Plasma Epinephrine ◽  
Lymphocyte Number

Prolonged strenuous exercise is followed by a temporary functional immune impairment. Low numbers of CD4+T helper (Th) and CD8+ T cytotoxic (Tc) cells are found in the circulation. These cells can be divided according to their cytokine profile into type 1 (Th1 and Tc1), which produce interferon-γ and interleukin (IL)-2, and type 2 (Th2 and Tc2) cells, which produce IL-4. The question addressed in the present study was whether exercise affected the relative balance between the circulating levels of these cytokine-producing T cells. Nine male runners performed treadmill running for 2.5 h at 75% of maximal oxygen consumption. The intracellular expression of cytokines was detected following stimulation with ionomycin and phorbol 12-myristate 13-acetate in blood obtained before, during, and after exercise. The percentage of type 1 T cells in the circulation was suppressed at the end of exercise and 2 h after exercise, whereas no changes were found in the percentage of type 2 T cells. Plasma epinephrine correlated negatively with the percentage of circulating CD8+ T cells producing IL-2, whereas peak IL-6 correlated with the percentage of CD8+ IL-4-producing T cells in the circulation. Peak plasma IL-6 correlated with plasma cortisol postrunning. In conclusion, the postexercise decrease in T lymphocyte number is accompanied by a more pronounced decrease in type 1 T cells, which may be linked to high plasma epinephrine. Furthermore, IL-6 may stimulate type 2 T cells, thereby maintaining a relatively unaltered percentage of these cells in the circulation compared with total circulating lymphocyte number.

Exercise-induced change in type 1 cytokine-producing CD8+ T cells is related to a decrease in memory T cells

2002 ◽  
Vol 93 (2) ◽  
pp. 645-648 ◽  
Author(s):  
Tobias Ibfelt ◽  
Emil Wolsk Petersen ◽  
Helle Bruunsgaard ◽  
Marie Sandmand ◽  
Bente Klarlund Pedersen
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Treadmill Running ◽  
Intracellular Expression ◽  
Ifn Γ ◽  
Exercise Induced ◽  
Response To Exercise ◽  
Type 1 Cytokine

In response to exercise, both CD4+ and CD8+ T cells are mobilized to the blood, but the levels of these cells decline below preexercise values in the postexercise period. T cells are functionally polarized, depending on the cytokines they produce. Type 1 cells produce, e.g., interferon (INF)-γ, whereas type 2 produce, e.g., interleukin (IL)-4. It was recently demonstrated that exercise induces a decrease in the percentage of type 1 T cells. The present study further investigated the mechanisms underlying the exercise-induced shift in the balance between type 1 and type 2 cytokine-producing cells. Seven healthy men performed 1.5 h of treadmill running with blood samples drawn before exercise, at the end of exercise, and 2 h after exercise. Intracellular expression of IFN-γ, IL-2, and IL-4 was detected in CD4+ and CD8+ T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin. Intracellular expression of IFN-γ within CD8+ cells was decreased in the postexercise period compared with values obtained immediately after exercise, whereas the expression of IL-2 and IL-4 did not change within the CD4+and CD8+ cell populations. The decrease in IFN-γ-producing CD8+ T cells postexercise was negatively correlated with a decrease in percentage of memory T cells within the CD8+ cells ( r = −0.94; P≤ 0.002). In conclusion, this study demonstrates that the exercise-induced change in type 1 cytokine-producing T cells is related to a decline in memory cells.

scholarly journals Differential Activation of CD8+Tumor-Specific Tc1 and Tc2 Cells by an IL-10-Producing Murine Plasmacytoma

1998 ◽  
Vol 6 (3-4) ◽  
pp. 331-342 ◽  
Author(s):  
Christoph Specht ◽  
Hans-Gerd Pauels ◽  
Christian Becker ◽  
Eckehart Kölsch
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Tumor Cells ◽  
T Cell Subsets ◽  
Early Stages ◽  
Specific Tolerance

The involvement of counteractiveCD8+T-cell subsets during tumor-specific immune responses was analyzed in a syngeneic murine plasmacytoma model.CD8+Tc cells against the immunogenic IL-10-producing BALB/c plasmacytoma ADJ-PC-5 can be easily induced by immunization of BALB/c mice with X-irradiated ADJ-PC-5 tumor cellsin vivoandin vitro. However, the failure of recipient mice to mount a protective Tc response against the tumor during early stages of a real or simulated tumor growth is not due to immunological ignorance, but depends on the induction of tumor-specific tolerance, involving a population of tumorinducedCD8+T cells that are able to inhibit the generation of tumor-specific Tc cells in a primary ADJ-PC-5-specific MLTC, using IFN-γas a suppressive factor. Whereas most longterm cultivated CD8+ADJ-PC-5-specific Tc lines produce type-1 cytokines on stimulation, at least two of them, which were derived from a primary MLTC, display a type-2 cytokine spectrum. Furthermore, the primaryin vitroTc response against ADJ-PC-5 cells shows characteristics of a Tc2 response. The Tc response is strictly depending on tumor-derived IL-10.CD8+Tc cells that are induced in a primary MLTC do not produce IFN-γ, and the tumor-specific Tc response is enhanced by IL-4 but suppressed by IFN-γor IL-12. In contrast, ADJ-PC- 5-specificCD8+Tc cells from immunized mice are IFN-γproducing Tc1 cells. Since the primaryin vitroTc response against the tumor is suppressed even by the smallest numbers of irradiated ADJ-PC-5-specific Tc1 cells via IFN-γthese Tc1 cells behave similar to the suppressiveCD8+T cells that are induced during early stages of ADJ-PC-5 tumorigenesis.

scholarly journals Clearance of HIV Type 1 Envelope Recombinant Sendai Virus Depends on CD4+T Cells and Interferon-γ But Not B Cells, CD8+T Cells, or Perforin

2010 ◽  
Vol 26 (7) ◽  
pp. 783-793 ◽  
Author(s):  
Sherri L. Surman ◽  
Scott A. Brown ◽  
Bart G. Jones ◽  
David L. Woodland ◽  
Julia L. Hurwitz
Keyword(s):  
T Cells ◽  
B Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Sendai Virus ◽  
Interferon Γ ◽  
Hiv Type 1

scholarly journals Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

Blood ◽  
1995 ◽  
Vol 86 (12) ◽  
pp. 4422-4429 ◽  
Author(s):  
L Pan ◽  
J Jr Delmonte ◽  
CK Jalonen ◽  
JL Ferrara
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Acute Gvhd ◽  
Cytokine Production ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Graft Versus Host ◽  
Stimulating Factor

The incidence and severity of acute graft-versus-host disease (GVHD) after allogeneic transplantation using peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) appear to be no worse than those after bone marrow transplantation, despite the presence of large numbers of T cells in the donor infusion. Experimental studies have shown that type-1 T cells (secreting interleukin-2 [IL-2] and interferon-gamma) mediate acute GVHD, whereas type-2 T cells (secreting IL-4 and IL-10) can prevent acute GVHD. We tested the hypothesis that G-CSF modulates T-cell function toward a type-2 response and thus reduces the severity of acute GVHD. B6 mice were injected with G-CSF or diluent for 4 days, and their splenic T cells were stimulated in vitro with alloantigen or mitogen in the absence of G-CSF. T cells from G-CSF-treated mice showed a significant increase in IL-4 production, with a simultaneous decrease in IL-2 and interferon-gamma production in response to both stimuli. We also examined the effect of G-CSF pretreatment of donors in a GVHD model (B6- ->B6D2F1). Survival was significantly improved in recipients of G-CSF- treated donors. Concanavalin-A-induced cytokine production at day 13 after transplantation also showed an increase in IL-4 along with a decrease in IL-2 and IFN-gamma production by splenocytes from recipients of G-CSF-treated bone marrow and T cells. These data show that pretreatment of donors with G-CSF polarizes donor T cells toward the production of type-2 cytokines, which is associated with reduced type-1 cytokine production and reduced severity of acute GVHD.

Clinical implications of the type 1/type 2 balance of helper T cells and P-glycoprotein function in peripheral T lymphocytes of myasthenia gravis patients

2010 ◽  
Vol 627 (1-3) ◽  
pp. 325-331 ◽  
Author(s):  
Masayuki Masuda ◽  
Sachiko Tanaka ◽  
Kanako Nakajima ◽  
Nao Yamada ◽  
Nobuhiro Ido ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Myasthenia Gravis ◽  
Helper T Cells ◽  
Clinical Implications ◽  
P Glycoprotein

scholarly journals IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics

2005 ◽  
Vol 6 (1) ◽  
Author(s):  
Luminita A Stanciu ◽  
Kevan Roberts ◽  
Nikolaos G Papadopoulos ◽  
Sang-Heon Cho ◽  
Stephen T Holgate ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cytokine Production ◽  
Type 1 Cytokine

scholarly journals Type 2 Bias of T Cells Expanded from the Blood of Melanoma Patients Switched to Type 1 by IL-12p70 mRNA–Transfected Dendritic Cells

2008 ◽  
Vol 68 (22) ◽  
pp. 9441-9450 ◽  
Author(s):  
Kira Minkis ◽  
Daniel G. Kavanagh ◽  
Galit Alter ◽  
Dusan Bogunovic ◽  
David O'Neill ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Melanoma Patients

Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy

2015 ◽  
Vol 175 ◽  
pp. 21-29 ◽  
Author(s):  
Hee Soon Shin ◽  
Hye-Jeong See ◽  
Sun Young Jung ◽  
Dae Woon Choi ◽  
Da-Ae Kwon ◽  
...  
Keyword(s):  
T Cells ◽  
Food Allergy ◽  
Mouse Model ◽  
Curcuma Longa ◽  
Helper T Cells
Sign in / Sign up

Export Citation Format

Share Document