scholarly journals Cardiac Bypass Pump Flow Management via NIRS Monitoring

2003 ◽  
Vol 17 (2-3) ◽  
pp. 477-482
Author(s):  
Andrew J. Macnab ◽  
Roy E. Gagnon ◽  
Faith A. Gagnon ◽  
Derek Blackstock ◽  
Jacques G. LeBlanc
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Redox Status ◽  
Status Change ◽  
Flow Management ◽  
Pump Flow ◽  
Pump Flow Rate ◽  
Cardiac Bypass

During cardiac surgery, bypass pumps rely on pressure monitors to evaluate flow. We studied whether it would be possible to optimize pump flow by monitoring changes in cerebral cytochromea,a3using NIRS to maintain cyt redox status at its pre-bypass level.Method: 18 healthy 7–45 kg swine were placed on bypass for repeated cycles of cooling and re-warming from 36 to 15 to 36°C in 3°C steps. Between each cycle, the swine's bypass pump blood flow rate was adjusted to restore cytochrome redox status to its pre-bypass value.Results: In all swine trials, the number of pump flow alterations imposed by NIRS monitoring ranged from 0 to 42, the average being 14 per trial. The best trial had 22 pump flow adjustments during which the range of cytochrome redox status change was 0.50±0.06μmol l–1. The average trial had a range of cytochrome redox status change of 1.50±0.22μmol l–1.Conclusion: NIRS-driven alterations in pump flow rate to maintain pre-bypass cytochrome redox status can be achieved successfully in the animal model.

A1107 CEREBRAL BLOOD FLOW AND METABOLISM ARE INDEPENDENT OF PUMP FLOW RATE DURING HYPOTHERMIC CARDIOPULMONARY BYPASS IN CHILDREN

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
F H Kem ◽  
W J Greeley ◽  
R M Ungerleider ◽  
T J Quill ◽  
B. Baldwin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Flow Rate ◽  
Hypothermic Cardiopulmonary Bypass ◽  
Pump Flow ◽  
Pump Flow Rate

The effect of normothermic cardiopulmonary bypass on hepatic blood flow in the dog

Perfusion ◽  
1986 ◽  
Vol 1 (4) ◽  
pp. 245-253 ◽  
Author(s):  
RT Mathie ◽  
JB Desai ◽  
KM Taylor
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Vascular Resistance ◽  
Flow Rate ◽  
Hepatic Blood Flow ◽  
Liver Blood Flow ◽  
Relative Reduction ◽  
Blood Flows ◽  
Pump Flow ◽  
Pump Flow Rate

Hepatic blood flow was investigated in two groups of eight anaesthetized dogs during and after one hour of either pulsatile or non-pulsatile cardiopulmonary bypass (CPB). Mean perfusion pressure was maintained at 60 mmHg. Hepatic arterial (HA) and portal venous (PV) blood flows were measured using electromagnetic flow probes, and hepatic O 2 consumption determined. The results demonstrate that: (a) pulsatile CPB reduces peripheral vascular resistance during and after perfusion, and more effectively preserves pump flow rate and cardiac output than non-pulsatile CPB; (b) total liver blood flow is sustained more effectively by pulsatile CPB than by non-pulsatile CPB due to relative preservation of both HA and PV flows; (c) hepatic O2 consumption is only marginally better preserved during and after pulsatile CPB than with non-pulsatile perfusion. We conclude that: (a) pulsatile CPB tends to maintain hepatic blood flow through a relative reduction in HA vascular resistance and an improvement in PV flow produced passively by a greater pump flow rate; (b) pulsatile CPB less effectively benefits hepatic O2 consumption because of poor O2 uptake from the hepatic PV blood supply.

Effect of pump flow rate on cerebral blood flow during hypothermic cardiopulmonary bypass in adults

1997 ◽  
Vol 11 (4) ◽  
pp. 415-419 ◽  
Author(s):  
David J. Cook ◽  
Jacqueline A. Proper ◽  
Thomas A. Orszulak ◽  
Richard C. Daly ◽  
William C. Oliver
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Flow Rate ◽  
Hypothermic Cardiopulmonary Bypass ◽  
Pump Flow ◽  
Pump Flow Rate

Effect of altering pump flow rate on cerebral blood flow and metabolism in infants and children

1993 ◽  
Vol 56 (6) ◽  
pp. 1366-1372 ◽  
Author(s):  
Frank H. Kern ◽  
Ross M. Ungerleider ◽  
J.G. Reves ◽  
Timothy Quill ◽  
L.Richard Smith ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Rate ◽  
Infants And Children ◽  
Pump Flow ◽  
Pump Flow Rate ◽  
In Infants And Children

Oxygen transport and oxygen consumption vs. cardiac output at different haematocrits

Perfusion ◽  
1987 ◽  
Vol 2 (1) ◽  
pp. 39-50 ◽  
Author(s):  
Esther P Hill ◽  
David C Willford ◽  
William Y Moores ◽  
Ronald Bellamy ◽  
William H Heydorn
Keyword(s):  
Cardiac Output ◽  
Oxygen Consumption ◽  
Flow Rate ◽  
Oxygen Transport ◽  
Blood Flow Rate ◽  
Fick Principle ◽  
Pump Flow ◽  
Arterial Blood ◽  
Group I ◽  
Pump Flow Rate

Oxygen consumption was measured in 10 anaesthetized, surgically instrumented domestic pigs on cardiopulmonary bypass while cardiac output (pump flow rate) was decreased. Oxygen consumption data (calculated by the Fick principle from blood flow rate and arterial and mixed venous content measurements) were plotted against total oxygen transport (TOT=QCaO2, where Q is pump flow rate and CaO2 is arterial blood oxygen content). Oxygen consumption (VO2) measurements were made in each animal at two haematocrits (approximately 30%, which is normal for pigs, and approximately 15%). In five of the animals (Group I) the measurements were made with normal haematocrit first, the blood was then haemodiluted with plasma or Dextran, and the measurements were repeated. In the remaining five animals (Group II), the haematocrit orderwas reversed. The plots showed two regions: above a certain value of TOT which we call critical TOT, VO2 was relatively independent of TOT, while at lower values of TOT, VO2 decreased approximately linearly with TOT. At the low haematocrit, the critical TOT (±S.E.M) was significantly lower ( P <0.05) than at normal haematocrit (6.9 ± 0.9 vs. 10.7 ± 1.2 ml/min/kg). Below the critical TOT, the curves for the two haematocrit levels were not significantly different. Above the critical TOT, the average VO2 was lower at the low haematocrit than at the normal haematocrit (6.0 ± 0.6 vs. 8.8 ± 1.1 ml/min/kg).

scholarly journals Chronic nonpulsatile blood flow. III. Effects of pump flow rate on oxygen transport and utilization in chronic nonpulsatile biventricular bypass

1996 ◽  
Vol 111 (4) ◽  
pp. 863-872 ◽  
Author(s):  
Ryuji Tominaga ◽  
William Smith ◽  
Alex Massiello ◽  
Hiroaki Harasaki ◽  
Leonard A.R. Golding
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Oxygen Transport ◽  
Pump Flow ◽  
Pump Flow Rate

scholarly journals The impact of temperature and pump flow rate during selective cerebral perfusion on regional blood flow in piglets

2013 ◽  
Vol 145 (1) ◽  
pp. 188-195 ◽  
Author(s):  
Jian Wang ◽  
Richard M. Ginther ◽  
Matthew Riegel ◽  
Rong Huang ◽  
Mahesh S. Sharma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Cerebral Perfusion ◽  
Regional Blood Flow ◽  
Selective Cerebral Perfusion ◽  
Pump Flow ◽  
Pump Flow Rate ◽  
The Impact

The Effect of Furosemide on the Intrarenal Blood Flow Distribution in the Dog

1972 ◽  
Vol 50 (8) ◽  
pp. 774-783 ◽  
Author(s):  
Serge Carrière ◽  
Michel Desrosiers ◽  
Jacques Friborg ◽  
Michèle Gagnan Brunette
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Urine Volume ◽  
Flow Distribution ◽  
Blood Flow Rate ◽  
Initial Distribution ◽  
Blood Flow Distribution ◽  
Intrarenal Blood Flow ◽  
Femoral Blood ◽  
Furosemide Administration

Furosemide (40 μg/min) was perfused directly into the renal artery of dogs in whom the femoral blood pressure was reduced (80 mm Hg) by aortic clamping above the renal arteries. This maneuver, which does not influence the intrarenal blood flow distribution, produced significant decreases of the urine volume, natriuresis, Ccreat, and CPAH, and prevented the marked diuresis normally produced by furosemide. Therefore the chances that systemic physiological changes occurred, secondary to large fluid movements, were minimized. In those conditions, however, furosemide produced a significant increase of the urine output and sodium excretion in the experimental kidney whereas Ccreat and CPAH were not affected. The outer cortical blood flow rate (ml/100 g-min) was modified neither by aortic constriction (562 ± 68 versus 569 ± 83) nor by the subsequent administration of furosemide (424 ± 70). The blood flow rate of the outer medulla in these three conditions remained unchanged (147 ± 52 versus 171 ± 44 versus 159 ± 54). The initial distribution of the radioactivity in each compartment remained comparable in the three conditions. In parallel with the results from the krypton-85 disappearance curves, the autoradiograms, silicone rubber casts, and EPAH did not suggest any change in the renal blood flow distribution secondary to furosemide administration.

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