scholarly journals Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Amanda S. Dye ◽  
Hong Huang ◽  
John A. Bauer ◽  
Robert P. Hoffman
Keyword(s):  
Blood Flow ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Vascular Function ◽  
Microvascular Complications ◽  
Muscle Blood Flow ◽  
Arterial Occlusion ◽  
Venous Occlusion ◽  
Before And After

Alterations of blood flow and endothelial function precede development of complications in type 1 diabetes. The effects of hyperglycemia on vascular function in early type 1 diabetes are poorly understood. To investigate the effect of hyperglycemia on forearm vascular resistance (FVR) and endothelial function in adolescents with type 1 diabetes, FVR was measured before and after 5 minutes of upper arm arterial occlusion using venous occlusion plethysmography in (1) fasted state, (2) euglycemic state (~90 mg/dL; using 40 mU/m2/min insulin infusion), and (3) hyperglycemic state (~200 mg/dL) in 11 adolescents with type 1 diabetes. Endothelial function was assessed by the change in FVR following occlusion. Seven subjects returned for a repeat study with hyperglycemia replaced by euglycemia. Preocclusion FVR decreased from euglycemia to hyperglycemia (P=0.003). Postocclusion fall in FVR during hyperglycemia was less than during euglycemia (P=0.002). These findings were not reproduced when hyperglycemia was replaced with a second euglycemia. These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes. In addition they have implications for future studies of endothelial function in type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes.

Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph

1996 ◽  
Vol 81 (3) ◽  
pp. 1418-1422 ◽  
Author(s):  
D. N. Proctor ◽  
J. R. Halliwill ◽  
P. H. Shen ◽  
N. E. Vlahakis ◽  
M. J. Joyner
Keyword(s):  
Blood Flow ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Venous Occlusion ◽  
Calf Blood Flow ◽  
Absolute Flow ◽  
Wide Range ◽  
Before And After ◽  
The Mean ◽  
Highly Correlated

Estimates of calf blood flow with venous occlusion plethysmography vary widely between studies, perhaps due to the use of different plethysmographs. Consequently, we compared calf blood flow estimates at rest and during reactive hyperemia in eight healthy subjects (four men and four women) with two commonly used plethysmographs: the mercury-in-silastic (Whitney) strain gauge and Dohn air-filled cuff. To minimize technical variability, flow estimates were compared with a Whitney gauge and a Dohn cuff on opposite calves before and after 10 min of bilateral femoral arterial occlusion. To account for any differences between limbs, a second trial was conducted in which the plethysmographs were switched. Resting flows did not differ between the plethysmographs (P = 0.096), but a trend toward lower values with the Whitney was apparent. Peak flows averaged 37% lower with the Whitney (27.8 +/- 2.8 ml.dl-1.min-1) than with the Dohn plethysmograph (44.4 +/- 2.8 ml.dl-1.min-1; P < 0.05). Peak flow expressed as a multiple above baseline was also lower with the Whitney (10-fold) than with the Dohn plethysmograph (14.5-fold; P = 0.02). Across all flows at rest and during reactive hyperemia, estimates were highly correlated between the plethysmographs in all subjects (r2 = 0.96-0.99). However, the mean slope for the Whitney-Dohn relationship was only 60 +/- 2%, indicating that over a wide range of flows the Whitney gauge estimate was 40% lower than that for the Dohn cuff. These results demonstrate that the same qualitative results can be obtained with either plethysmograph but that absolute flow values will generally be lower with Whitney gauges.

Forearm Vasoreactivity in Type I Diabetic Subjects

2001 ◽  
Vol 26 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Jason D. Allen ◽  
Michael Welsch ◽  
Nikki Aucoin ◽  
Robert Wood ◽  
Matt Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Vascular Function ◽  
Forearm Blood Flow ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Type I ◽  
Handgrip Exercise ◽  
Blood Flows

This study compared forearm vasoreactivity in 15 Type 1 diabetic subjects with 15 healthy controls. The groups were matched for age, exercise capacity, and the absence of other cardiovascular risk factors. Vasoreactivity was measured using strain gauge plethysmography, at rest, after arterial occlusion (OCC), and following OCC coupled with handgrip exercise (ROCC). Forearm blood flows were significantly elevated between conditions 2.58 ± 0.37 ml/100mltissue at rest to 26.80 ± 6.56 after OCC and 32.80 ± 8.26ml/100mltissue following ROCC in Type 1 diabetic subjects. There were no differences in forearm blood flow between groups for any of the conditions. These data indicate the degree of forearm blood flow is directly related to the intensity of the vasodilatory stimulus. However, our study did not reveal evidence of impaired vasodilatory capacity in Type 1 diabetic subjects compared to controls in the absence of other risk factors. Key words: IDDM, vascular function, exercise, fitness, and reactive hyperemia

scholarly journals Effects of Glucose Control and Variability on Endothelial Function and Repair in Adolescents with Type 1 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Robert P. Hoffman ◽  
Amanda S. Dye ◽  
Hong Huang ◽  
John A. Bauer
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Hemoglobin A1c ◽  
Glucose Monitoring ◽  
Area Under The Curve ◽  
Vascular Occlusion ◽  
Venous Occlusion ◽  
Mean Glucose

Background. Endothelial dysfunction and increased inflammation are precursors of cardiovascular disease in type 1 diabetes (T1D) and occur even in adolescents with T1D. The goal of this study was to determine the relationship of endothelial dysfunction to various measures of glycemia. Research Design and Methods. Forearm blood flow (FBF, venous occlusion plethysmography) was measured before and after 5 min of upper arm vascular occlusion in 17 adolescents with uncomplicated type 1 diabetes. Endothelial function was assessed as postocclusion FBF and forearm vascular resistance (FVR, mean arterial pressure/FBF). Fasting glucose, 72 hour mean glucose and standard deviation from continuous glucose monitoring, hemoglobin A1c, and hemoglobin A1c by duration area under the curve were used to assess immediate, short-term, and intermediate- and long-term glycemia. Results. Postocclusion FBF (r=-0.53, P=0.030) negatively correlated and postocclusion FVR positively correlated (r=0.52, P=0.031) with hemoglobin A1c levels. FVR was positively associated with log 3 day mean glucose (r=0.55, P=0.027). Postocclusion FBF (2.8±1.1 versus 3.4±0.5 mL/dL/min, mean ± SE, P=0.084) tended to be lower and FVR (31.4±10.4 versus 23.9±4.4 mmHg dL min/mL, P=0.015) was significantly higher in subjects with hemoglobin A1c above the median (8.3%) compared to those with lower hemoglobin A1c levels. Conclusions. These results demonstrate that poor intermediate-term glycemic control is associated with impaired endothelial function.

scholarly journals Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Arturo Orea-Tejeda ◽  
Karla Balderas-Muñoz ◽  
Lilia Castillo-Martínez ◽  
Oscar Infante-Vázquez ◽  
Raúl Martínez Memije ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Endothelial Function ◽  
Vascular Function ◽  
Systolic Heart Failure ◽  
Maximum Amplitude ◽  
Right Heart Failure ◽  
Right Heart ◽  
Heart Failure Patients ◽  
Before And After

Background. Ivabradine is an If ion current inhibitor that has proved to reduce mortality in patients with systolic heart failure by slowing heart rate without decreasing myocardial contractility. Photoplethysmography is a simple, low-cost optical technique that can evaluate vascular function and detect changes in blood flow, pulse, and swelling of tissular microvascular space.Objective. To evaluate the effect of ivabradine on endothelial function by photoplethysmography in diastolic and right heart failure patients.Methodology. 15 patients were included (mean age of 78.1 ± 9.2 years) with optimally treated diastolic and right heart failure. They underwent photoplethysmography before and after induced ischemia to evaluate the wave blood flow on the finger, using the maximum amplitude time/total time (MAT/TT) index. Two measurements were made before and after oral Ivabradine (mean 12.5 mg a day during 6 months of followup).Results. In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 () in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (), before versus after ischemia and before versus after Ivabradine intervention, respectively.Conclusions. Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients.

scholarly journals Elevated Skeletal Muscle Blood Flow in Noncomplicated Type 1 Diabetes Mellitus

Hypertension ◽  
1999 ◽  
Vol 34 (5) ◽  
pp. 1080-1085 ◽  
Author(s):  
Gerald Vervoort ◽  
Jack F. Wetzels ◽  
Jos A. Lutterman ◽  
Laurus G. van Doorn ◽  
Jo H. Berden ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow

C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patients

2004 ◽  
Vol 286 (1) ◽  
pp. E14-E19 ◽  
Author(s):  
Bo-Lennart Johansson ◽  
Jan Sundell ◽  
Karin Ekberg ◽  
Cathrine Jonsson ◽  
Marko Seppänen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Muscle Blood Flow ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Skeletal Muscle Blood Flow ◽  
C Peptide ◽  
Type 1 Diabetic Patients

Patients with type 1 (insulin-dependent) diabetes show reduced skeletal muscle blood flow and coronary vasodilatory function despite intensive insulin therapy and good metabolic control. Administration of proinsulin C-peptide increases skeletal muscle blood flow in these patients, but a possible influence of C-peptide on myocardial vasodilatory function in type 1 diabetes has not been investigated. Ten otherwise healthy young male type 1 diabetic patients (Hb A1c 6.6%, range 5.7-7.9%) were studied on two consecutive days during normoinsulinemia and euglycemia in a double-blind, randomized, crossover design, receiving intravenous infusion of C-peptide (5 pmol·kg-1·min-1) for 120 min on one day and saline infusion on the other day. Myocardial blood flow (MBF) was measured at rest and during adenosine administration (140 μg·kg-1·min-1) both before and during the C-peptide or saline infusions by use of positron emission tomography and [15O]H2O administration. Basal MBF was not significantly different in the patients compared with an age-matched control group, but adenosine-induced myocardial vasodilation was 30% lower ( P < 0.05) in the patients. During C-peptide administration, adenosine-stimulated MBF increased on average 35% more than during saline infusion ( P < 0.02) and reached values similar to those for the healthy controls. Moreover, as evaluated from transthoracal echocardiographic measurements, C-peptide infusion resulted in significant increases in both left ventricular ejection fraction (+5%, P < 0.05) and stroke volume (+7%, P < 0.05). It is concluded that short-term C-peptide infusion in physiological amounts increases the hyperemic MBF and left-ventricular function in type 1 diabetic patients.

scholarly journals Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2436
Author(s):  
Antonio Cutruzzolà ◽  
Martina Parise ◽  
Rosarina Vallelunga ◽  
Francesco Lamanna ◽  
Agostino Gnasso ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Olive Oil ◽  
Vascular Function ◽  
Saturated Fatty Acids ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Repeated Measurements ◽  
Flow Mediated Dilation

Post-prandial hyperglycemia can be relevant in developing early manifestations of atherosclerosis. EVOO (Extra Virgin Olive Oil), rich in saturated fatty acids and commonly used in the Mediterranean diet, seems to control post-prandial hyperglycemia better than butter. Subjects with type 1 diabetes are at higher risk of developing cardiovascular disease and show endothelial dysfunction, an early manifestation of atherosclerosis in the first years of the disease. Our study aims to evaluate whether EVOO and butter influence endothelial function in subjects with type 1 diabetes when added to a single high glycemic index (HGI) meal. In this exploratory cross-over study, 10 subjects with type 1 diabetes and 6 healthy subjects were scheduled to receive two types of HGI meals: one enriched with EVOO and one with butter. Before and after each test meal at different time points, all subjects underwent the evaluation of endothelial function by flow-mediated dilation technique, glucose and lipids measurements, and gastric emptying assessment by ultrasound. Flow-mediated dilation significantly increased after EVOO-enriched meal compared with butter in subjects with type 1 diabetes (two-way-repeated measurements ANOVA, p = 0.007). In patients with type 1 diabetes, the add-on of EVOO to HGI meal improves vascular function compared to butter, which has detrimental effects.

Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria

2001 ◽  
Vol 53 (2) ◽  
pp. 73-83 ◽  
Author(s):  
M.I Wiggam ◽  
S.J Hunter ◽  
C.N Ennis ◽  
B Sheridan ◽  
A.B Atkinson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Insulin Action ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications
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