scholarly journals Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation?

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Gunvor S. Fosnes ◽  
Stian Lydersen ◽  
Per G. Farup

Introduction. Constipation is a common adverse drug reaction.Objective. Study associations between drugs and constipation in nursing home residents.Design. Cross-sectional study.Material and Methods. Nursing home residents above 60 years of age were included. Demographics, diet, physical activity, activity of daily living, nutritional status, use of drugs, and diseases were recorded. Constipation was defined as functional constipation or constipation-predominant IBS according to the Rome III criteria and/or regular use of laxatives. Drugs were classified according to the Anatomical-Therapeutic-Chemical Classification System (ATC), and anticholinergic effect was noted.Results. In all, 79 men and 188 women with a mean age of 85.4 (SD 7.1) years were included. The prevalence of constipation was 71.5%. Use of drugs in general, including polypharmacy, was not associated with constipation. Reduced activity of daily living (OR = 0.71, 95% CI : 0.60–0.84,P<0.001),other antidepressants(N06AX) (OR 3.08, 95% CI : 1.09–8.68,P=0.03), andbenzodiazepine derivatives(N05BA) (OR = 2.80, 95% CI : 1.12–7.04,P=0.03) were significantly associated with constipation; drugs with markedly anticholinergic effect (OR = 3.7, 95% CI : 0.78–17.53,P=0.10),natural opium alkaloid(N02AA) (OR = 5.01, 95% CI : 0.95–25.94,P=0.06), andpropionic acid derivatives(M01AE) (OR = 7.00, 95% CI : 0.75–65.08,P=0.09) showed a trend.Conclusion.In elderly with constipation, focus should be on specific groups of drugs and nonpharmacological factors, not on drugs in general.

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Eva Mann ◽  
Sascha Köpke ◽  
Burkhard Haastert ◽  
Kaisu Pitkälä ◽  
Gabriele Meyer

2012 ◽  
Vol 15 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Ines Wulff ◽  
Marita Kölzsch ◽  
Sonja Kalinowski ◽  
Kirsten Kopke ◽  
Thomas Fischer ◽  
...  

2013 ◽  
Vol 12 (5) ◽  
pp. 586-589 ◽  
Author(s):  
Gojiro Nakagami ◽  
Nao Kimura ◽  
Kimie Takehara ◽  
Tetsuro Nakamura ◽  
Makoto Kawashima ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sarah Raes ◽  
Sophie Vandepitte ◽  
Delphine De Smedt ◽  
Herlinde Wynendaele ◽  
Yannai DeJonghe ◽  
...  

Abstract Background Knowledge about the relationship between the residents’ Quality of Life (QOL) and the nursing home price is currently lacking. Therefore, this study investigates the relationship between 11 dimensions of QOL and nursing homes price in Flemish nursing homes. Methods The data used in this cross-sectional study were collected by the Flemish government from years 2014 to 2017 and originates from 659 Flemish nursing homes. From 2014 to 2016, data on the QOL of 21,756 residents was assessed with the InterRAI instrument. This instrument contains 11 QOL dimensions. Multiple linear regression analyses were conducted to examine the research question. Results The multiple linear regressions indicated that a 10 euro increase in the daily nursing home price is associated with a significant decrease (P <  0.001) of 0.1 in 5 dimensions of QOL (access to services, comfort and environment, food and meals, respect, and safety and security). Hence, our results indicate that the association between price and QOL is very small. When conducting a subgroup analysis based on ownership type, the earlier found results remained only statistically significant for private nursing homes. Conclusion Our findings show that nursing home price is of limited importance with respect to resident QOL. Contrary to popular belief, our study demonstrates a limited negative effect of price on QOL. Further research that includes other indicators of QOL is needed to allow policymakers and nursing home managers to improve nursing home residents’ QOL.


PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0223704 ◽  
Author(s):  
Marinda Henskens ◽  
Ilse M. Nauta ◽  
Susan Vrijkotte ◽  
Katja T. Drost ◽  
Maarten V. Milders ◽  
...  

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shu-yang Yu ◽  
Teng-hong Lian ◽  
Peng Guo ◽  
Li-xia Li ◽  
Du-yu Ding ◽  
...  

Abstract Background Apathy is one of the most common symptoms of Alzheimer’s disease (AD), however, correlations of apathy with demographic variables, cognitive functions, neuropsychiatric symptoms, activity of daily living and olfactory functions in AD patients are still lacking comprehensive investigations. Methods This is a cross-sectional study. Total 124 typical AD patients were consecutively recruited from April 2014 to April 2017. In 124 AD patients, 47 cases (37.9%) were male and 77 cases were female; patients’ age were 43–93 years with an average of 68 years. Patients were divided into AD with apathy (AD-A) and AD with no apathy (AD-NA) groups according to the score of Modified Apathy Evaluation Scale, then were evaluated cognitive functions, neuropsychiatric symptoms and activity of daily living, and tested olfactory functions. Above variables were compared between AD-A and AD-NA groups. Further correlation analyses and linear regression analysis were performed between apathy and above variables. Results Compared with AD-NA group, global cognitive level, verbal memory, verbal fluency and activity of daily living were significantly compromised in AD-A group (P < 0.002); depression and agitation were severely displayed in AD-A group (P < 0.002). Apathy was negatively correlated with global cognitive function, verbal memory, verbal fluency and activity of daily living (P < 0.05). There was no significant difference of olfactory functions between the two groups (P > 0.002), and correlations between apathy and olfactory threshold, olfactory identification and global olfactory function were significant (P < 0.05) but quite weak (|r| < 0.3). Further linear regression analysis showed that only verbal fluency and instrumental activities of daily living were independently associated with apathy. Conclusions Independent correlations among apathy, verbal fluency and instrumental activities of daily living in AD patients might be related to the common brain area involved in their pathogeneses.


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