scholarly journals Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Olarewaju M. Oluba ◽  
Augustine O. Olusola ◽  
George O. Eidangbe ◽  
Leye J. Babatola ◽  
E. Chukwu Onyeneke
Keyword(s):  
Normal Control ◽  
Aqueous Extract ◽  
Plasmodium Berghei ◽  
Ganoderma Lucidum ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Malarial Infection ◽  
Dose Dependent

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 mg/kg chloroquine (CQ). Significant increases in all the lipoprotein fractions were observed in infected untreated mice compared with normal control mice. Treatment with 100 and 250 mg/kg G. lucidum extract produced significant reduction in serum total cholesterol (TC) and low-density cholesterol (LDL-C) contents compared with 500 mg/kg G. lucidum and CQ. Treatment with CQ, however, produced significant reduction in hepatic TC and LDL-C compared with the extract. A dose-dependent significant increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the G. lucidum treated mice compared with normal control but significantly lower compared with CQ-treated mice. Liver HDL-C level was significantly higher in CQ-treated mice compared with normal control and significantly lower compared with G. lucidum-treated and infected untreated mice. A dose-dependent effect of the extract was observed in both serum and liver very-low density lipoprotein cholesterol (VLDL-C). The implication of these results is discussed with respect to the parasite survival and proliferation in the serum and liver.

scholarly journals Aqueous extract of Azadirachta indica leaves favorably alters the course of streptozotocin-induced diabetes in rats: A comparative prospective cohort study

2020 ◽  
Vol 7 (7) ◽  
pp. 3877-3889
Author(s):  
Obiajulu C. Ezeigwe ◽  
Francis C. Ezeonu ◽  
Chukwudi O. Okani ◽  
Daniel N. Onwusulu ◽  
Maryclare E. Onuegbu
Keyword(s):  
Aqueous Extract ◽  
Azadirachta Indica ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Organ System ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Albino Rats ◽  
Low Density ◽  
The Mean

Introduction: Azadirachta indica (neem) is one of the plants commonly used in African traditional medicine for the treatment and management of diabetes mellitus. The present study was undertaken to evaluate the effect of aqueous extract of A. indica leaves on hematology, lipid profile and organ-system function of streptozotocin-induced diabetic male rats. Methods: Thirty albino rats of Wistar strain, weighing between 120 and 150 g, were randomly divided into 6 groups (A-F) and used for the study. Group A was used as a healthy normal control. Groups B-F were induced with diabetes using 50 mg/kg bodyweight (bw.) of streptozotocin. Group B was diabetic untreated; Group C was treated with 100 mg/kg bw. metformin; Groups D to F were treated with 100, 200 and 400 mg/kg bw. of the aqueous extract, respectively. The treatment was carried out daily for a period of 28 days. At the end of the experimental period, the hematological parameters were analyzed using auto haematology analyser. Lipid profiles and histopathological investigations were performed using standard methods. Results: The results obtained showed that aqueous extract of A. indica significantly (p < 0.05) increased the hemoglobin concentration, packed cell volume, red blood cell count, and platelet count of the streptozotocin-induced diabetic rats compared with those of the diabetic-untreated rats. The mean hemoglobin concentrations for groups A, B, C, D, E and F were 11.78, 8.200, 15.18, 13.88, 14.03 and 14.93, respectively. Treatment with the graded doses of the aqueous extract of A. indica significantly (p < 0.05) reduced the total cholesterol, low-density lipoprotein cholesterol, triglycerides and very-low-density lipoprotein, compared with those of the diabetic-untreated control. Treatment also significantly (p < 0.05) increased the high-density lipoprotein cholesterol (HDL-c), compared with that of the control. The mean HDL-c concentration for groups A, B, C, D, E and F were 49.58, 29.79, 40.89, 38.53, 40.40 and 46.54, respectively. The histopathological studies showed regeneration of the pancreas, liver, kidney, heart, brain and lungs for the groups treated with the extract, compared with the diabetic-untreated animals that revealed severe damage to the organ-system functions. Conclusion: These results suggest that the aqueous extract of A. indica can be considered as an excellent remedy for diabetes and a substitute for drugs to reduce complications associated with diabetic conditions.

Effect of Honey & Olive Oil Supplemented Bio-Yoghurt Feeding on Lipid Profile, Blood Glucose and Hematological Parameters in Rats

2019 ◽  
Vol 15 (2) ◽  
pp. 140-147
Author(s):  
Magdy M. Ismail ◽  
El-Tahra M. Ammar ◽  
Abd El-Wahab E. Khalil ◽  
Mohamed Z. Eid
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Olive Oil ◽  
Body Weight Gain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background and Objective: Yoghurt, especially bio-yoghurt has long been recognized as a product with many health benefits for consumers. Also, honey and olive oil have considerable nutritional and health effects. So, the effect of administration of yoghurt made using ABT culture and fortified with honey (2 and 6%), olive oil (1 and 4%) or honey + olive oil (2+1 and 6+4% respectively) on some biological and hematological properties of rats was investigated.Methods:The body weight gain, serum lipid level, blood glucose level, serum creatinine level, Glutamic Oxaloacetic Transaminase (GOT) activity, Glutamic Pyruvic Transaminase (GPT) activity, leukocytes and lymphocytes counts of rats were evaluated.Results:Blending of bio-yoghurt with rats&#039; diet improved body weight gain. Concentrations of Total plasma Cholesterol (TC), High-Density Lipoprotein cholesterol (HDL), Low-Density Lipoprotein cholesterol (LDL), Very Low-Density Lipoprotein cholesterol (VLDL) and Triglycerides (TG) significantly lowered in plasma of rats fed bio-yoghurt. Levels of TC, LDL, VLDL, and TG also decreased in rat groups feed bio-yoghurt supplemented with honey and olive oil. LDL concentrations were reduced by 10.32, 18.51, 34.17, 22.48, 43.30% in plasma of rats fed classic starter yoghurt, ABT yoghurt, ABT yoghurt contained 6% honey, ABT yoghurt contained 4% olive oil and ABT yoghurt contained 6% honey + 4% olive oil respectively. The blood glucose, serum creatinine, GOT and GPT values of rats decreased while white blood cells and lymphocytes counts increased by feeding bioyoghurt contained honey and olive oil.Conclusion:The findings enhanced the multiple therapeutic effects of bio-yoghurt supplemented with honey and olive oil.

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