scholarly journals A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mian Bilal Alam ◽  
Amin Kadoura ◽  
Magesh Sathaiah
Keyword(s):  
Case Report ◽  
Liver Biopsy ◽  
Hepatic Injury ◽  
Total Bilirubin ◽  
Fatal Case ◽  
Fulminant Liver Failure ◽  
Drug Induced ◽  
Common Cause ◽  
Extensive Evaluation ◽  
Extensive List

Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.

scholarly journals Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia

2018 ◽  
Vol 11 (3) ◽  
pp. 880-882 ◽  
Author(s):  
Elizabeth Pan ◽  
Eric Hsieh ◽  
Caroline Piatek
Keyword(s):  
Case Report ◽  
Cancer Therapy ◽  
Cancer Patients ◽  
Immune Thrombocytopenia ◽  
Drug Induced ◽  
Gastrointestinal Malignancies ◽  
Common Cause ◽  
Immune Mediated ◽  
Chemotherapy Agents ◽  
Platinum Derivative

Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Oxaliplatin is a platinum derivative commonly used in gastrointestinal malignancies and is associated with drug-induced immune thrombocytopenia.

A case report of fulminant hepatitis due to ribociclib with confirmed by liver biopsy in breast cancer

2021 ◽  
pp. 107815522110279
Author(s):  
Atakan Topcu ◽  
Ayse Irem Yasin ◽  
Abdallah TM Shbair ◽  
Mehmet Besiroglu ◽  
Melih Simsek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Liver Biopsy ◽  
Fulminant Hepatitis ◽  
Liver Toxicity ◽  
Growth Factor Receptor ◽  
Drug Induced ◽  
Laboratory Findings ◽  
First Case ◽  
Abdominal Mri

Introduction Breast cancer is the most frequently diagnosed cancer in women worldwide. Ribociclib is now frequently used in the treatment of metastatic hormone-positive and human epidermal growth factor receptor 2 (HER 2)-negative breast cancer. Case Report A 54-year-old woman with breast cancer presented at a clinic in November 2017 with multiple lung and bone metastases. After receiving multiple lines of treatment due to disease progression, ribociclib and fulvestrant were initiated. Grade 4 toxicity was observed due to ribociclib during follow-up, and ribociclib was discontinued permanently. Management & Outcome: Given that liver transaminases and bilirubin elevation persisted despite discontinuation of the treatment, other reasons for liver toxicity were investigated. Abdominal MRI showed no liver metastases, although there was acute hepatitis. A liver biopsy was performed to determine the etiology. The pathology result was compatible with drug-induced acute fulminant toxic hepatitis. After liver biopsy, prednisolone treatment was initiated, after which the laboratory findings normalized. Discussion Although there are reported cases showing improvement in liver enzymes after ribociclib discontinuation, in our case, no recovery from hepatotoxicity was noticed. The treatment was changed to another hormonal pathway therapy option, exemestane. To the best of our knowledge, this is the first case in the literature reporting this rare side effect of ribociclib, which is a liver biopsy-proven fulminant hepatitis.

scholarly journals Acute Hepatitis Associated with “Thermogenic Fat Burner” Weight Loss Supplementation: A Case Report

2018 ◽  
Vol 13 (4) ◽  
pp. e32-e35 ◽  
Author(s):  
Marko Popovic ◽  
Maxime Billick ◽  
Matthew R. Robinson
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Case Report ◽  
Liver Biopsy ◽  
Leaf Extract ◽  
Total Bilirubin ◽  
Garcinia Cambogia ◽  
Painless Jaundice ◽  
Laboratory Investigations ◽  
Tea Leaf

Thermogenic fat burner treatments are used to increase an individual’s basal metabolic rate, thus mimicking exercise and inducing weight loss. In rare circumstances, these supplements are associated with hepatotoxicity. We describe the case of a 21-year-old male who presented with painless jaundice and a weight loss of 25% of body weight following 8 weeks of thermogenic fat burner supplementation. Laboratory investigations revealed a severe transaminase and bilirubin elevation (AST/ALT>2000 IU/L, total bilirubin=148 μmol/L). An otherwise extensive workup, including a liver biopsy, did not identify a precise cause. Two weeks after discharge, his condition stabilized with a significant improvement in his laboratory abnormalities. In this report, we discuss the likely ingredients that contributed to the patient’s condition, including Garcinia cambogia and green tea leaf extract, and review similar cases documented in the literature. 

scholarly journals A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Jessica Parrott ◽  
Mitch Tener ◽  
Katie Dennis ◽  
Matthew Sharpe ◽  
Cecily Clark-Ganheart
Keyword(s):  
Liver Biopsy ◽  
Hepatic Injury ◽  
Status Asthmaticus ◽  
Atypical Presentation ◽  
Short Term ◽  
Drug Induced ◽  
Respiratory Status ◽  
Maternal Hypertension ◽  
Spectrum Disorders ◽  
In Pregnancy

Background. Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. Conclusion. The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity.

scholarly journals A case report of early biliary cirrhosis which showed a serologically interesting course after suffering from drug-induced hepatic injury

Kanzo ◽  
1979 ◽  
Vol 20 (8) ◽  
pp. 861-867 ◽  
Author(s):  
Takao MORITO ◽  
Susumu WATANABE ◽  
Nobuyoshi IIZUKA ◽  
Hiroshi YOSHIDA ◽  
Reijii KASUKAWA ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatic Injury ◽  
Biliary Cirrhosis ◽  
Drug Induced

scholarly journals Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report

2020 ◽  
Vol 10 (03) ◽  
pp. e210-e212 ◽  
Author(s):  
Anna Whelan ◽  
Joanna Izewski ◽  
Charles Berkelhammer ◽  
Jami Walloch ◽  
Helen H. Kay
Keyword(s):  
Case Report ◽  
Chronic Hypertension ◽  
Drug Induced ◽  
Common Cause ◽  
Drug Induced Liver Injury ◽  
Autoimmune Conditions ◽  
Acute Fatty Liver ◽  
Elevated Transaminases ◽  
Iatrogenic Preterm Delivery ◽  
In Pregnancy

Abstract Background Drug-induced liver injury is a common cause of transaminitis, occurring in up to 5% of patients who are hospitalized for liver failure. In pregnancy, transaminitis is seen in conditions which may require expedited delivery. Case A 39-year-old G2P0010 at 272/7 weeks' gestation with chronic hypertension on labetalol was found to have elevated transaminases. Evaluation for preeclampsia, acute fatty liver, nonalcoholic steatohepatitis, cholelithiasis, infections, and autoimmune conditions were all negative. Labetalol was then discontinued, and liver biopsy was performed. After discontinuation of labetalol, her hepatitis improved, and she was discharged on hospital day 12 and went on to deliver at term. Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm delivery.

Liver Biopsy Culture in the Diagnosis of Miliary Tuberculosis: A Case Report

1952 ◽  
Vol 22 (1) ◽  
pp. 124-127 ◽  
Author(s):  
John M. Rumball ◽  
George L. Baum
Keyword(s):  
Case Report ◽  
Liver Biopsy ◽  
Miliary Tuberculosis

High-dose methotrexate-induced reversible grade 4 hyperbilirubinaemia and transaminitis in an adolescent with Burkitt Leukaemia

2021 ◽  
Vol 14 (1) ◽  
pp. e237512
Author(s):  
Sanjeev Khera ◽  
Randhir Ranjan ◽  
Sateesh Ramachandran ◽  
Ajay Beriwal
Keyword(s):  
Liver Injury ◽  
Clinical Significance ◽  
Short Latency ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Drug Induced ◽  
Common Cause ◽  
Drug Induced Liver Injury ◽  
Dose Methotrexate

Symptomatic drug-induced liver injury (DILI) is an uncommon problem. Direct DILI is dose-related, predictable with short latency (hour to days) and is generally associated with transient and reversible transaminitis without jaundice. Antimetabolites including methotrexate are a common cause for direct DILI. Hepatotoxicity associated with high-dose methotrexate (HD-MTX) is generally transient and includes reversible elevation of transaminase in up to 60% and associated hyperbilirubinaemia (≤grade 2) in 25% of courses and therefore is of no clinical significance. Severe grades of DILI with HD-MTX (grade ≥4) are extremely rare. We describe an adolescent with Burkitt leukaemia who had reversible grade 4 DILI including hyperbilirubinaemia postfirst course of HD-MTX. Rechallenge with two-third dose of HD-MTX in subsequent chemotherapeutic cycle did not cause recurrence of DILI.

scholarly journals Complications of drowning: A case report

2019 ◽  
Vol 59 (5) ◽  
pp. 284-8
Author(s):  
Felicia Anita Wijaya ◽  
I Gde Doddy Kurnia Indrawan
Keyword(s):  
United States ◽  
Case Report ◽  
Brain Damage ◽  
The United States ◽  
Accidental Death ◽  
Common Cause ◽  
Death By Drowning

Unintentional drowning is the sixth most common cause of accidental death, accounting for 4,086 deaths (1.4 per 100,000) in the United States in 2007.1 In children, drowning is the second leading cause of injury-related death, and those aged 1–3 years have the highest rate of drowning.2 More than 1,400 pediatric drownings were reported in the United States in 2008.3 Many drowning deaths are due to lack of supervision in the bathtub, unprotected access to a pool, or lack of swimming skills.3 For every death by drowning, six children are hospitalized for drowning, and up to 10% of survivors experience severe brain damage.2

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