scholarly journals Maxillary and Frontal Bone Simultaneously Involved in Brown Tumor due to Secondary Hyperparathyroidism in a Hemodialysis Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Suheil Artul ◽  
Abdalla Bowirrat ◽  
Mustafa Yassin ◽  
Zaher Armaly
Keyword(s):  
Renal Failure ◽  
Differential Diagnosis ◽  
Primary Hyperparathyroidism ◽  
Hemodialysis Patient ◽  
Frontal Bone ◽  
Brown Tumor ◽  
Unusual Manifestation ◽  
Brown Tumors ◽  
Left Maxillary Sinus ◽  
End Stage

Brown tumors are rare focal giant cell lesions of the bone caused by primary hyperparathyroidism (HPT). Brown tumor was reported in 1891; it presents as the end-stage findings of HPT. Common involvements are skull and pelvic girdle. We describe a case of 46-year-old female hemodialysis patient, with secondary HPT in whom multiple masses lesions of the left maxillary sinus and frontal bone were radiologically suspected to be brown tumor. This unusual manifestation of secondary HPT can be expected to occur with increased longevity of patients with renal failure and illustrates the need to include brown tumor in the differential diagnosis.

scholarly journals A Rare Cause of Primary Hyperparathyroidism Presented with Giant Adenoma, Multiple Brown Tumors And End Stage Renal Failure

2014 ◽  
Vol 3 (2) ◽  
pp. 1262
Author(s):  
Abdulmecit Yildiz ◽  
Turkay Kirdak ◽  
Alparslan Ersoy ◽  
Canan Ersoy ◽  
Ozlem Saraydaroglu ◽  
...  
Keyword(s):  
Renal Failure ◽  
Primary Hyperparathyroidism ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
End Stage

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Health Concern ◽  
Oral Manifestations ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
The Mean ◽  
End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.

scholarly journals Achievement of Right Ventricular Pacing by Use of a Long Guiding Catheter in a Hemodialysis Patient Presenting Significant Tortuosity of Vasculature

2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Polychronis Dilaveris ◽  
Skevos Sideris ◽  
Sofia Vaina ◽  
Konstantinos Gatzoulis ◽  
Christodoulos Stefanadis
Keyword(s):  
Renal Failure ◽  
Hemodialysis Patient ◽  
Ventricular Pacing ◽  
Patient Case ◽  
Right Ventricular Pacing ◽  
End Stage Renal Failure ◽  
And Performance ◽  
End Stage ◽  
Percutaneous Transluminal ◽  
Guiding Catheter

Increased vascular calcification and tortuosity are rather common in end-stage renal failure patients who are on hemodialysis. It renders manipulation of catheters and performance of percutaneous transluminal interventions more difficult than expected. Such vascular alterations may be evident in large veins and pose significant difficulties in placement of pacing leads as shown in our case. To overcome such difficulties, we demonstrated in this patient case that long guiding catheters may be of particular value.

scholarly journals Computed Tomography Findings of an Unusual Maxillary Sinus Mass: Brown Tumor Due to Tertiary Hyperparathyroidism

2013 ◽  
Vol 3 ◽  
pp. 55 ◽  
Author(s):  
Canan Altay ◽  
Nezahat Erdoğan ◽  
Erdem Eren ◽  
Sedat Altay ◽  
Şebnem Karasu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Differential Diagnosis ◽  
Maxillary Sinus ◽  
Bone Lesion ◽  
Brown Tumor ◽  
Left Cheek ◽  
Incisional Biopsy ◽  
Maxillofacial Region ◽  
Tertiary Hyperparathyroidism ◽  
Left Maxillary Sinus

Brown tumor is a non-neoplastic bone lesion that develops secondary to hyperparathyroidism and it is very rare in the maxillofacial region. We report the case of a 59-year-old man who presented with pain and a swelling in the left cheek. Computed tomography (CT) demonstrated an expansile and radioluscent lesion in the left maxillary sinus. Incisional biopsy was performed, and the diagnosis was Brown tumor. Brown tumor must be considered in the differential diagnosis of expansile lesions of maxillary sinus.

scholarly journals Surgical approach and clinical outcome of a deforming brown tumor at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure

2006 ◽  
Vol 50 (5) ◽  
pp. 963-967 ◽  
Author(s):  
Christianne T.S. Leal ◽  
Paulo G.S. Lacativa ◽  
Elaine M.S. Gomes ◽  
Reinaldo C. Nunes ◽  
Flávio Luiz F. de S. Costa ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Brown Tumor ◽  
Maxillary Bone ◽  
Brown Tumors ◽  
Serum Pth ◽  
The Right ◽  
Stage Renal Disease ◽  
End Stage ◽  
Fast Increase

Brown tumors are relatively uncommon but they are serious complications of renal osteodystrophy. We describe a 31-year-old woman with end-stage renal disease who had undergone hemodialysis for nine years and developed severe secondary hyperparathyroidism and a maxilla brown tumor despite increasing doses of oral calcitriol and calcium carbonate. The fast increase of the right maxillary bone tumor led to indication of parathyroidectomy (PTx). Despite normalization of serum PTH there was a slow regression of the mass and the patient still complained about her appearance after two-years of follow-up. Excision of the maxillary mass followed by recontouring of the maxilla was then performed, with adequate masticator rehabilitation.

Giant cell tumor of bone in a patient with diagnosis of primary hyperparathyroidism: a challenge in differential diagnosis with brown tumor

2013 ◽  
Vol 43 (5) ◽  
pp. 693-697 ◽  
Author(s):  
Barbara Rossi ◽  
Virginia Ferraresi ◽  
Maria Luisa Appetecchia ◽  
Mariangela Novello ◽  
Carmine Zoccali
Keyword(s):  
Differential Diagnosis ◽  
Primary Hyperparathyroidism ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Brown Tumor

scholarly journals Brown tumor due to primary hyperparathyroidism resulting in acute paraparesis: Case report and literature review

2020 ◽  
Vol 11 ◽  
pp. 355
Author(s):  
Ahmed Taha Elsayed Shaaban ◽  
Mostafa Ibrahem ◽  
Ahmed Saleh ◽  
Abdulrazzaq Haider ◽  
Abdulnasser Alyafai
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Lesion ◽  
Excisional Biopsy ◽  
Brown Tumor ◽  
Parathyroid Tumor ◽  
Osteitis Fibrosa Cystica ◽  
Lytic Bone Lesion ◽  
Brown Tumors ◽  
Acute Paraparesis ◽  
Operative Decompression

Background: Brown tumor (Osteoclastoma) is a rare benign, focal, lytic bone lesion most commonly attributed to a parathyroid adenoma; it occurs in approximately 5% of patients with primary hyperparathyroidism, and 13% of patients with secondary hyperparathyroidism. Most tumors are located in the mandible, pelvis, ribs, and large bones; only rarely is it found in the axial spine. Case Description: A 37-year-old male with primary hyperparathyroidism presented with an MR-documented T4 and T5 brown tumor (Osteitis Fibrosa Cystica) resulting in an acute paraparesis. The patient successfully underwent excisional biopsy of an expansile, enhancing, bony destructive lesion at the T4-5 level. Subsequently, he required subtotal excision of a left upper parathyroid tumor. Conclusion: Patient with primary hyperparathyroidism may acutely present with paraparesis attributed to brown tumors of the spine warranting emergent operative decompression.

Nephrogenic Systemic Fibrosis Mimicking Inflammatory Breast Carcinoma

2007 ◽  
Vol 131 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Garron J. Solomon ◽  
Elizabeth Wu ◽  
Paul Peter Rosen
Keyword(s):  
Renal Failure ◽  
Differential Diagnosis ◽  
Breast Carcinoma ◽  
Nephrogenic Systemic Fibrosis ◽  
Inflammatory Breast Carcinoma ◽  
First Case ◽  
Nephrogenic Fibrosing Dermopathy ◽  
Peau D’Orange ◽  
Stage Renal Disease ◽  
End Stage

Abstract Nephrogenic systemic fibrosis, previously known as nephrogenic fibrosing dermopathy, is a newly recognized systemic fibrosing disorder primarily affecting patients with chronic renal failure. Patients with skin involvement often develop papules and plaques with peau d'orange surface changes. The lower extremities and trunk are most commonly affected. The most important histologic differential diagnosis is with scleromyxedema. To our knowledge, we report the first case of nephrogenic systemic fibrosis involving the breasts of a 61-year-old woman with end-stage renal disease, clinically mimicking inflammatory breast carcinoma. We propose that nephrogenic systemic fibrosis be considered in the differential diagnosis as a rare possibility when cutaneous changes in the breast suggest inflammatory breast carcinoma in a patient with renal failure.

scholarly journals Brown tumor of the jaw after pregnancy and lactation in a MEN1 patient

2016 ◽  
Vol 2016 ◽  
Author(s):  
Anna Casteràs ◽  
Lídia Darder ◽  
Carles Zafon ◽  
Juan Antonio Hueto ◽  
Margarita Alberola ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Parathyroid Glands ◽  
Brown Tumor ◽  
Mineral Density ◽  
Men 1 ◽  
Pregnancy And Lactation ◽  
Brown Tumors

Summary Skeletal manifestations of primary hyperparathyroidism (pHPT) include brown tumors (BT), which are osteoclastic focal lesions often localized in the jaws. Brown tumors are a rare manifestation of pHTP in Europe and USA; however, they are frequent in developing countries, probably related to vitamin D deficiency and longer duration and severity of disease. In the majority of cases, the removal of the parathyroid adenoma is enough for the bone to remineralize, but other cases require surgery. Hyperparathyroidism in MEN1 develops early, and is multiglandular and the timing of surgery remains questionable. To our knowledge, there are no reports of BT in MEN 1 patients. We present a 29-year-old woman with MEN 1 who developed a brown tumor of the jaw 24 months after getting pregnant, while breastfeeding. Serum corrected calcium remained under 2.7 during gestation, and at that point reached a maximum of 2.82 mmol/L. Concomitant PTH was 196 pg/mL, vitamin D 13.7 ng/mL and alkaline phosphatase 150 IU/L. Bone mineral density showed osteopenia on spine and femoral neck (both T-scores = −1.6). Total parathyroidectomy was performed within two weeks, with a failed glandular graft autotransplantation, leading to permanent hypoparathyroidism. Two months after removal of parathyroid glands, the jaw tumor did not shrink; thus, finally it was successfully excised. We hypothesize that higher vitamin D and mineral requirements during maternity may have triggered an accelerated bone resorption followed by appearance of the jaw BT. We suggest to treat pHPT before planning a pregnancy in MEN1 women or otherwise supplement with vitamin D, although this approach may precipitate severe hypercalcemia. Learning points: Brown tumors of the jaw can develop in MEN 1 patients with primary hyperparathyroidism at a young age (less than 30 years). Pregnancy and lactation might trigger brown tumors by increasing mineral and vitamin D requirements. Early parathyroidectomy is advisable in MEN 1 patients with primary hyperparathyroidism, at least before planning a pregnancy. Standard bone mineral density does not correlate with the risk of appearance of a brown tumor. Removal of parathyroid glands does not always lead to the shrinkage of the brown tumor, and surgical excision may be necessary.

Chronic renal failure causing brown tumors and myelopathy

1999 ◽  
Vol 90 (2) ◽  
pp. 242-246 ◽  
Author(s):  
Igor Fineman ◽  
J. Patrick Johnson ◽  
Pier-Luigi Di-Patre ◽  
Harvinder Sandhu
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Secondary Hyperparathyroidism ◽  
Lupus Erythematosus ◽  
Surgical Reconstruction ◽  
Brown Tumor ◽  
Content Type ◽  
Spinal Reconstruction ◽  
Increased Risk ◽  
Brown Tumors

✓ Brown tumors (osteoclastomas) are histologically benign lesions that are caused by primary or secondary hyperparathyroidism. Secondary hyperparathyroidism is a frequent complication of chronic renal failure. Skeletal brown tumors are relatively uncommon, and brown tumors that involve the spine are considered very rare. The authors present the case of a 37-year-old woman with systemic lupus erythematosus and hemodialysis-dependent anuric renal failure, in whom spinal cord compression developed due to a brown tumor and pathological fracture at T-9. The patient underwent transthoracic decompressive surgery and spinal reconstruction in which cadaveric femoral allograft and instrumentation were used. Brown tumors of the vertebral column require surgical treatment if medical therapy and parathyroidectomy fail to halt their progression or if acute neurological deterioration occurs. In patients with renal failure bone healing is delayed and there is an increased risk that healing will fail because the metabolic derangements can result in severe osteoporosis. Surgical reconstruction of the spine may require the use of augmentation with instrumentation and aggressive treatment of hyperparathyroidism to achieve successful outcomes.

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