scholarly journals Investigation of Regenerated Cellulose/Poly(acrylic acid) Composite Films for Potential Wound Healing Applications: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Manjula Bajpai ◽  
S. K. Bajpai ◽  
Dinesh Gautam

Regenerated cellulose/poly(acrylic acid) composite films have been synthesized for wound dressing applications. The water absorbency of these films was studied as a function of amount of cross-linker N,N′-methylenebisacrylamide and cellulose contents in the feed mixture. The samples, having different compositions, showed tensile strength and percent elongation in the range of 9.98×105 to 13.40×105 N/m2 and 110 to 265, respectively. The water vapor transmission rate (WVTR) for various films was found to be in the range of 2.03 to 7.18 mg/cm2/h. These films were loaded with antibacterial drug miconazole nitrate and their release was studied in the physiological pH at 37°C. The release data was found to fit well the diffusion controlled Higuchi model. Finally the films demonstrated fair antibacterial and antifungal action, thus establishing their strong candidature as wound dressing materials.

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1149
Author(s):  
Naresh Shahi ◽  
Gautam Joshi ◽  
Byungjin Min

In this study, agricultural residue from black oat, a cover crop usually grown to improve soil nutrients between the periods of regular crop production, was used as a source of cellulose fibers. Concentrations of 1, 3, and 5 wt. % of regenerated cellulose (RC) fibers blended in poly(vinyl alcohol) (PVA) solution were used to prepare the reinforced composite films (CFs) by the solvent cast method. Compared to neat PVA film (control), the effects of RC addition on functional properties of CFs, such as water absorption, transparency, thermal stability, and mechanical property were investigated. All CFs with different RC concentrations exhibited improved mechanical property and thermal stability while the swelling property was decreased, and no significant changes were observed in the film transparency as compared with the control film. Among the CFs, films with 3% RC significantly decreased water vapor transmission rate, swelling, and soluble fraction (p < 0.05). In addition, Young’s modulus and tensile strength were increased by 40 MPa and 3 MPa, respectively, while elongation at break was decreased by 4%, compared to the control film. The results indicate that RC from black oat might be feasible as potential bio fillers to improve film properties in a bio-based composite matrix.


2000 ◽  
Vol 10 (11) ◽  
pp. 2548-2552 ◽  
Author(s):  
Yasuo Gotoh ◽  
(the late) Ryo Igarashi ◽  
Yutaka Ohkoshi ◽  
Masanobu Nagura ◽  
Kensuke Akamatsu ◽  
...  

2000 ◽  
Vol 29 (2) ◽  
pp. 92-93 ◽  
Author(s):  
Masahiro Suzuki ◽  
Naomi Takada ◽  
Toshiki Koyama ◽  
Satoshi Kobayashi ◽  
Mutsumi Kimura ◽  
...  

2006 ◽  
Vol 922 ◽  
Author(s):  
Lei Liu ◽  
Jaime C. Grunlan

AbstractPoly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were used to tailor the microstructure of single-walled carbon nanotubes (SWNTs) in both aqueous solutions and dry composite films. Microstructural changes were achieved as the pH of aqueous suspensions were changed, as evidenced by elevated suspension viscosity, scanning electron microscopy and electrical conductivity measurements. The ability to tailor microstructure is useful for aqueous SWNT processing and solid polymer nanocomposites.


Author(s):  
Ion Călina ◽  
Maria Demeter ◽  
Anca Scărișoreanu ◽  
Veronica Sătulu ◽  
Bogdana Mitu

We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11-67 nm. Hydrogels with gel fraction above 85% and the best-swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m-2 day-1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8h.


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