scholarly journals Salivary RNA Signatures in Oral Cancer Detection

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Prashanth Panta ◽  
Venkat Raghavender Venna
Keyword(s):  
Oral Cancer ◽  
Nucleic Acids ◽  
Cancer Detection ◽  
Squamous Cell ◽  
Early Stage ◽  
Point Of Care ◽  
High Sensitivity ◽  
Squamous Cell Carcinomas ◽  
Mortality And Morbidity ◽  
Oral Squamous Cell Carcinomas

Oral squamous cell carcinomas (OSCC) are common malignancies that affect almost a million people every year. The key issue in reducing mortality and morbidity associated with OSCC is to develop novel strategies to identify OSCC at an early stage. One such strategy is the identification of biomarkers. So far, more than 100 biomarkers are recognized in the detection of oral cancer and they range from proteins to nucleic acids (DNAs, RNAs). Detection of ribose nucleic acids in saliva is a recent trend in diagnosing oral cancer. Studies have shown statistically significant changes in the levels of salivary transcriptomes in patients with oral squamous cell carcinomas. These biomarkers have displayed high sensitivity and specificity. Also, new point-of-care platforms such as oral fluid nanosensor test are now available that will soon emerge as chair-side tools for early detection of oral cancer. The aim of this review is to highlight the importance of salivary transcriptomes in oral cancer detection.

Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas

Oral Oncology ◽  
2016 ◽  
Vol 52 ◽  
pp. 75-84 ◽  
Author(s):  
Manuel Weber ◽  
Christos Iliopoulos ◽  
Patrick Moebius ◽  
Maike Büttner-Herold ◽  
Kerstin Amann ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Early Stage ◽  
Macrophage Polarization ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

The value of histological grading of biopsy and resection specimens in early stage oral squamous cell carcinomas

2018 ◽  
Vol 46 (6) ◽  
pp. 1001-1006 ◽  
Author(s):  
Eric A. Dik ◽  
Norbertus A. Ipenburg ◽  
Peter A. Kessler ◽  
Robert J.J. van Es ◽  
Stefan M. Willems
Keyword(s):  
Squamous Cell ◽  
Early Stage ◽  
Squamous Cell Carcinomas ◽  
Histological Grading ◽  
Oral Squamous Cell Carcinomas

A study of phosphorylated ERK1/2 and COX-2 in early stage (T1-T2) oral squamous cell carcinomas

2008 ◽  
Vol 37 (9) ◽  
pp. 535-542 ◽  
Author(s):  
Tine M. Søland ◽  
Camilla Husvik ◽  
Hanna Strømme Koppang ◽  
Morten Boysen ◽  
Leiv Sandvik ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Early Stage ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Cox 2 ◽  
Stage T1

scholarly journals p53 Expression in Oral cancer: A study of 50 cases

2015 ◽  
Vol 5 (9) ◽  
pp. 747-751 ◽  
Author(s):  
S Ghanghoria ◽  
A Ghanghoria ◽  
A Shukla
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Squamous Cell Carcinomas ◽  
Biopsy Material ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas ◽  
Formalin Fixed Paraffin Embedded

Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion.Materials and Methods: Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion.Conclusion: Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.Journal of Pathology of Nepal (2015) Vol. 5, 747-751

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

p53 alterations in betel quid- and tobacco-associated oral squamous cell carcinomas from Taiwan

2007 ◽  
Vol 27 (6) ◽  
pp. 243-248 ◽  
Author(s):  
Yong-Kie Wong ◽  
Tsung-Yun Liu ◽  
Kuo-Wei Chang ◽  
Shu-Chun Lin ◽  
Tsurn-Waan Chao ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Betel Quid ◽  
Oral Squamous Cell Carcinomas
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