scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

scholarly journals Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

2017 ◽  
Vol 114 (15) ◽  
pp. E3110-E3118 ◽  
Author(s):  
Moustafa R. K. Ali ◽  
Mohammad Aminur Rahman ◽  
Yue Wu ◽  
Tiegang Han ◽  
Xianghong Peng ◽  
...  
Keyword(s):  
Cell Death ◽  
Mechanism Of Action ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Mouse Tumor ◽  
Maximal Induction

Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a promising strategy for combating cancer in which AuNRs absorb near-infrared light and convert it into heat, causing cell death mainly by apoptosis and/or necrosis. Developing a valid PPTT that induces cancer cell apoptosis and avoids necrosis in vivo and exploring its molecular mechanism of action is of great importance. Furthermore, assessment of the long-term fate of the AuNRs after treatment is critical for clinical use. We first optimized the size, surface modification [rifampicin (RF) conjugation], and concentration (2.5 nM) of AuNRs and the PPTT laser power (2 W/cm2) to achieve maximal induction of apoptosis. Second, we studied the potential mechanism of action of AuNRs-PPTT using quantitative proteomic analysis in mouse tumor tissues. Several death pathways were identified, mainly involving apoptosis and cell death by releasing neutrophil extracellular traps (NETs) (NETosis), which were more obvious upon PPTT using RF-conjugated AuNRs (AuNRs@RF) than with polyethylene glycol thiol-conjugated AuNRs. Cytochrome c and p53-related apoptosis mechanisms were identified as contributing to the enhanced effect of PPTT with AuNRs@RF. Furthermore, Pin1 and IL18-related signaling contributed to the observed perturbation of the NETosis pathway by PPTT with AuNRs@RF. Third, we report a 15-month toxicity study that showed no long-term toxicity of AuNRs in vivo. Together, these data demonstrate that our AuNRs-PPTT platform is effective and safe for cancer therapy in mouse models. These findings provide a strong framework for the translation of PPTT to the clinic.

A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

2016 ◽  
Vol 4 (27) ◽  
pp. 4667-4674 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Min Guo ◽  
Lu An ◽  
Shi-Ping Yang ◽  
Qian-Ling Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized.

scholarly journals DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5235
Author(s):  
Galina M. Proshkina ◽  
Elena I. Shramova ◽  
Marya V. Shilova ◽  
Ivan V. Zelepukin ◽  
Victoria O. Shipunova ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Therapeutic Potential ◽  
Infrared Light ◽  
Strong Reduction ◽  
Her2 Positive ◽  
Excellent Stability

Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

Gold nanorods@mSiO2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy

2012 ◽  
Vol 22 (31) ◽  
pp. 16095 ◽  
Author(s):  
Hongyan Tang ◽  
Shun Shen ◽  
Jia Guo ◽  
Baisong Chang ◽  
Xinguo Jiang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Polymer Shell ◽  
Near Infrared Light ◽  
Smart Polymer

scholarly journals PREPARATION AND CHARACTERIZATION OF A NEAR-INFRARED LIGHT RESPONSIVE MICROCAPSULE SYSTEM FOR CANCER THERAPY

2014 ◽  
Vol 07 (01) ◽  
pp. 1350037 ◽  
Author(s):  
YINGFENG DI ◽  
SISI CUI ◽  
YUEQING GU
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Self Assembly ◽  
Near Infrared ◽  
Infrared Light ◽  
Layer By Layer ◽  
Near Infrared Light ◽  
Nir Light ◽  
Alternative Material ◽  
Confocal Fluorescence Imaging

A novel near-infrared light responsive microcapsule system, gold nanorod-covered DOX-loaded hollow CaCO 3 microcapsule ( AuNR -HM-DOX) is developed for cancer therapy. The hollow CaCO 3 microcapsules were prepared based on the self-assembly between chitosan and sodium alginate on CaCO 3 particles via layer-by-layer technique, and then covered with gold nanorods to obtain the microcapsule system. Upon near-infrared (NIR) irradiation, microcapsule with gold nanorods can convert the absorbed NIR light into heat. Meanwhile, doxorubicin (DOX), a chemotherapy drug, is loaded into the microcapsule system via electrostatic adsorption for combined photothermal therapy and chemotherapy. Properties of AuNR -HM-DOX including grain diameter, optical spectra were characterized. Confocal fluorescence imaging was performed to observe the morphology of the capsules and existence of DOX in the core, confirming the successful loading of DOX. The release of DOX from the capsules under continuous NIR irradiation was investigated to evaluate the temperature responsiveness of AuNR -HM-DOX. Results indicate that AuNR -HM-DOX microcapsules possess uniform particle size and high light responsiveness. The combination of chemical and physical therapy of AuNR -HM-DOX features great potential as an adjuvant therapeutic alternative material for combined cancer therapy.

Cu2−xSe@mSiO2–PEG core–shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4361-4370 ◽  
Author(s):  
Xijian Liu ◽  
Qian Wang ◽  
Chun Li ◽  
Rujia Zou ◽  
Bo Li ◽  
...  
Keyword(s):  
Power Density ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Light Radiation ◽  
Shell Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Core Shell Nanoparticles

A difunctional nanoplatform based on the Cu2−xSe@mSiO2–PEG core–shell nanoparticles demonstrates an excellent biocompatibility and can be used for combining photothermal- and chemotherapies driven by NIR light.

scholarly journals Nanomaterial Applications in Photothermal Therapy for Cancer

Materials ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 779 ◽  
Author(s):  
Austin Doughty ◽  
Ashley Hoover ◽  
Elivia Layton ◽  
Cynthia Murray ◽  
Eric Howard ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Tissue ◽  
Infrared Light ◽  
Cancer Therapies ◽  
Targeted Cancer Therapy ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Graphene Oxide Sheets

As a result of their unique compositions and properties, nanomaterials have recently seen a tremendous increase in use for novel cancer therapies. By taking advantage of the optical absorption of near-infrared light, researchers have utilized nanostructures such as carbon nanotubes, gold nanorods, and graphene oxide sheets to enhance photothermal therapies and target the effect on the tumor tissue. However, new uses for nanomaterials in targeted cancer therapy are coming to light, and the efficacy of photothermal therapy has increased dramatically. In this work, we review some of the current applications of nanomaterials to enhance photothermal therapy, specifically as photothermal absorbers, drug delivery vehicles, photoimmunological agents, and theranostic tools.

Near infrared light-actuated gold nanorods with cisplatin–polypeptide wrapping for targeted therapy of triple negative breast cancer

Nanoscale ◽  
2015 ◽  
Vol 7 (36) ◽  
pp. 14854-14864 ◽  
Author(s):  
Bing Feng ◽  
Zhiai Xu ◽  
Fangyuan Zhou ◽  
Haijun Yu ◽  
Qianqian Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Triple Negative ◽  
Infrared Light ◽  
Near Infrared Light

Gold nanorods with cisplatin–polypeptide wrapping were developed for combinational photothermal therapy and chemotherapy of triple negative breast cancer.

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