scholarly journals Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Taylor Pindi Sala ◽  
Jean-Marie Michot ◽  
Renaud Snanoudj ◽  
Marion Dollat ◽  
Emmanuel Estève ◽  
...  
Keyword(s):  
Systemic Vasculitis ◽  
Transplant Rejection ◽  
Immunoglobulin A ◽  
Corticosteroid Treatment ◽  
Successful Outcome ◽  
Henoch Schonlein Purpura ◽  
Small Vessels ◽  
History Of ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. Vasculitis involves skin and sciatic peroneal nerve and she received systemic corticosteroid treatment. Because of four relapses and corticosteroid dependence, the patient was treated with rituximab (two intravenous infusions of 1000 mg given two weeks apart). Successful outcome was observed along two years of follow-up. This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials.

scholarly journals Gastrointestinal Involvement in Henoch Schonlein Purpura : A Case Report

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Siti Kamariah CM ◽  
Rohaizan Y
Keyword(s):  
Case Report ◽  
Bowel Wall ◽  
Systemic Vasculitis ◽  
Bowel Ischemia ◽  
Gastrointestinal Involvement ◽  
Henoch Schonlein Purpura ◽  
Small Vessels ◽  
Abdominal Symptoms ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura or anaphylactoid purpura is a systemic vasculitis of unknown cause that affects small vessels and mainly involves the skin, joints, gastrointestinal tract and kidneys. Gastrointestinal involvement occurs in more than half of patients and is thought to be related to edema and intramural haemorrhage. Radiologically the gastrointestinal findings are mainly those of bowel ischemia with “thumbprinting” and bowel wall oedema. Although this disease is usually treated conservatively, aggressive intervention is occasionally performed because of acute abdominal symptoms due to complications, such as perforation, intussusception and obstruction. This report illustrates a case of Henoch-Schonlein purpura with acute abdominal symptoms due to intussusception.

scholarly journals Development of Immunoglobulin A Nephropathy in a Kidney Transplant in a Patient with Previous History of Henoch-Schönlein Purpura Glomerulonephritis

Nephron ◽  
1993 ◽  
Vol 63 (2) ◽  
pp. 247-248 ◽  
Author(s):  
Dujanah H. Mousa ◽  
Wedad Al-Harbi ◽  
Jag Mohan Dhar ◽  
Mohamed H. Al-Sulaiman ◽  
Abdullah A. Al-Khader
Keyword(s):  
Kidney Transplant ◽  
Immunoglobulin A ◽  
Previous History ◽  
Immunoglobulin A Nephropathy ◽  
Henoch Schonlein Purpura ◽  
History Of ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Successful Treatment of Hemorrhagic Bullous Henoch-Schönlein Purpura with Oral Corticosteroid: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Celebi Kocaoglu ◽  
Ramazan Ozturk ◽  
Yasar Unlu ◽  
Fatma Tuncez Akyurek ◽  
Sukru Arslan
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Female Patient ◽  
Oral Corticosteroid ◽  
Systemic Vasculitis ◽  
Immunoglobulin A ◽  
Henoch Schonlein Purpura ◽  
Hemorrhagic Bullae ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a vasculitis of small-sized blood vessels, resulting from immunoglobulin-A-mediated inflammation. It is the most common acute systemic vasculitis in childhood and mainly affects skin, gastrointestinal tract, joints, and kidneys. The characteristic rash of HSP consists of palpable purpuric lesions 2 to 10 mm in diameter concentrating in the buttocks and lower extremities. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. This report describes a 4.5-year-old female patient with HSP associated with hemorrhagic bullous lesions.

scholarly journals SEVERE GASTROINTESTINAL MANIFESTATIONS COMPLICATING HENOCH-SCHÖNLEIN PURPURA IN ADULT: A RARE CASE IN INDONESIA

2018 ◽  
Vol 11 (11) ◽  
pp. 11
Author(s):  
William Ray Cassidy ◽  
Ketut Suryana ◽  
Dewi Catur Wulandari
Keyword(s):  
Systemic Vasculitis ◽  
Renal Involvement ◽  
Immunoglobulin A ◽  
Henoch Schonlein Purpura ◽  
Gastrointestinal Manifestations ◽  
Patient Morbidity ◽  
Schonlein Purpura ◽  
Term Monitoring ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP), also known as immunoglobulin A vasculitis, is a self-limiting, small vessel systemic vasculitis rarely found in adults characterized by palpable purpura, arthritis or arthralgia, gastrointestinal, and renal involvement. We report a case of a 31-year-old male with HSP complicated with severe gastrointestinal manifestations mimicking acute abdomen. He was successfully managed with conservative approach. Meticulous diagnosis, treatment, and long-term monitoring are important to reduce patient morbidity.

scholarly journals Henoch-Schonlein purpura in child: a case report and review of the literature

2020 ◽  
Vol 8 (1) ◽  
pp. 193
Author(s):  
Vijay B. Sonawane ◽  
V. A. Kotrashetti ◽  
Kapil S. Bainade ◽  
Shweta Nair ◽  
Sushil Yewale
Keyword(s):  
Leukocytoclastic Vasculitis ◽  
Immunoglobulin A ◽  
Oral Prednisolone ◽  
Female Child ◽  
Review Of The Literature ◽  
Henoch Schonlein Purpura ◽  
Small Vessels ◽  
Schonlein Purpura ◽  
Multiple Episodes ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura (HSP) is the most common vasculitis of childhood and is characterized by leukocytoclastic vasculitis and immunoglobulin A deposition in the small vessels in the skin, joints, gastrointestinal tract and kidney. We report a 6 year old female child presented with rashes over both legs and buttocks along with joint pain and abdominal pain and multiple episodes of vomiting. Patient was diagnosed with HSP and treated with oral prednisolone followed by methylprednisolone and other supportive care.

scholarly journals A case of severe multifocal enteritis caused by unusual pattern of Henoch-Schönlein purpura

2014 ◽  
Vol 05 (01) ◽  
pp. 033-036
Author(s):  
Sung Bum Kim ◽  
Tae Nyeun Kim ◽  
Kook Hyun Kim
Keyword(s):  
Vascular Endothelium ◽  
Epigastric Pain ◽  
Oral Prednisone ◽  
Immunoglobulin A ◽  
Neutrophil Infiltration ◽  
Wall Thickening ◽  
Henoch Schonlein Purpura ◽  
Unusual Pattern ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

AbstractA 58-year-old male visited our hospital with a complaint of epigastric pain for 2 days. Physical examination showed no purpuric skin lesion. Abdominal computed tomography scan showed concentric segmental wall thickening of the duodenum. Esophagogastroduodenoscopy showed diffuse erythematous mucosa with exudates at the duodenum. On 4th hospital day, he developed hematochezia. colonoscopy showed circumferential erythematous mucosa with ulcerative hemorrhage at terminal ileum. The microscopic examination identified lots of neutrophil infiltration and deposition of immunoglobulin A (IgA) on vascular endothelium. Treatment with oral prednisone 40 mg was initiated. On 19th day, the patient developed hematuria and proteinuria. Histologic examination on renal biopsy showed focal proliferative glomerulonephritis and strongly positive IgA staining in the glomerular mesangium. Severe hemorrhagic mucosa on endoscopy, deposition of IgA on kidney and intestinal vascular endothelium suggests the diagnosis of Henoch–Schönlein purpura (HSP). We report severe multifocal enteritis caused by unusual pattern of HSP.

Steroid Effects on the Course of Abdominal Pain in Children With Henoch-Schonlein Purpura

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1018-1021
Author(s):  
NORMAN D. ROSENBLUM ◽  
HARLAND S. WINTER
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Symptom ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Intestinal Bleeding ◽  
Controlled Trials ◽  
Henoch Schonlein Purpura ◽  
Intestinal Lesions ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most common gastrointestinal symptom, but intestinal bleeding and intussusception may occur. Previous studies have supported the use of steroids in managing the abdominal pain of Henoch-Schonlein purpura.1,2 Because there are no controlled trials using steroids in this disease, their value in affecting the intestinal lesions of Henoch-Schonlein purpura remains unknown. The purpose of this retrospective study was to assess the effect of corticosteroids on the outcome of abdominal pain in children with Henoch-Schonlein purpura. PATIENTS AND METHODS

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