Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.

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Distal Humerus as Delayed Site of Metastasis from Small Cell Carcinoma of Gallbladder

Case Reports in Gastrointestinal Medicine ◽

10.1155/2013/946835 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mutahir A. Tunio ◽

Mushabbab AlAsiri ◽

Asma Mohammed F. Ali ◽

Eyad Fawzi AlSaeed ◽

Muhammad Shuja ◽

...

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

World Literature ◽

Case Reports ◽

Locally Advanced ◽

Distal Humerus ◽

Small Cell ◽

Rare Entity ◽

Dismal Prognosis ◽

Advanced Stages

Background. Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature.Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis.Conclusion. SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival.

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Small Cell Carcinoma of the Uterine Cervix Misdiagnosed as Squamous Cell Carcinoma

Cancer and Clinical Oncology ◽

10.5539/cco.v2n1p36 ◽

2012 ◽

Vol 2 (1) ◽

Author(s):

Aymen Lagha ◽

Nadia Bouzid ◽

Samia Kanoun Belajouza ◽

Soumaya Labidi ◽

Asma Saiidi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Uterine Cervix ◽

Small Cell

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Adjuvant chemotherapies for small cell carcinoma of the uterine cervix

Cancer Treatment An Update ◽

10.1007/978-2-8178-0765-2_100 ◽

1994 ◽

pp. 479-481

Author(s):

T. C. Chang ◽

H. C. Chang ◽

C. H. Lai ◽

S. Hsueh ◽

S. F. Huang ◽

...

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Small Cell

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Small Cell Carcinoma of the Prostate in an Elderly Patient: A Case Report and Review of the Literature

Rare Tumors ◽

10.4081/rt.2016.6657 ◽

2016 ◽

Vol 8 (4) ◽

pp. 176-178 ◽

Cited By ~ 3

Author(s):

Dale Alan Whitaker ◽

Daniel H. Miller ◽

Niveditha Jagadesh ◽

Gerald W. Strong ◽

Lauren Hintenlang ◽

...

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Current Knowledge ◽

Case Reports ◽

The United States ◽

Small Cell ◽

Rapid Progression ◽

Retrospective Case

Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation therapy, androgen deprivation therapy, or prostatectomy. Here we present the case of an elderly 89-year-old Caucasian male who was diagnosed with SCC of the prostate. Despite proceeding with a course of definitive radiotherapy, the patient experienced rapid progression of disease and ultimately elected to discontinue radiation therapy and receive hospice care.

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Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2011-0320-oa ◽

2012 ◽

Vol 136 (2) ◽

pp. 163-171 ◽

Cited By ~ 125

Author(s):

Bradley M. Turner ◽

Philip T. Cagle ◽

Irma M. Sainz ◽

Junya Fukuoka ◽

Steven S. Shen ◽

...

Keyword(s):

Lung Adenocarcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Lung Squamous Cell Carcinoma ◽

Negative Control ◽

Small Cell ◽

Tumor Type ◽

Napsin A ◽

N 93

Context.—Differentiation of non–small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA. Objectives.—To compare Nap-A versus TTF-1 in the typing of primary lung carcinoma and the differentiation of primary lung ACA from carcinomas of other sites. Design.—Immunohistochemistry for Nap-A and TTF-1 was performed on tissue microarrays of 1674 cases of carcinoma: 303 primary lung ACAs (18.1%), 200 primary squamous cell lung carcinomas (11.9%), 52 primary small cell carcinomas of the lung (3.1%), and carcinomas of the kidney (n = 320; 19.1%), thyroid (n = 96; 5.7%), biliary (n = 89; 5.3%), bladder (n = 47; 2.8%), breast (n = 93; 5.6%), colon (n = 95; 5.7%), liver (n = 96; 5.7%), ovaries (n = 45; 2.7%), pancreas (n = 48; 2.9%), prostate (n = 49; 2.9%), stomach (n = 93; 5.6%), and uterus (n = 48; 2.9%). Cases were evaluated against a negative control as negative, weak positive, and strong positive. Results.—Nap-A was more sensitive than TTF-1 for primary lung ACA (87% versus 64%; P < .001). Nap-A was more specific than TTF-1 for primary lung ACA versus all tumors, excluding kidney, independent of tumor type (P < .001). Conclusions.—Nap-A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma. A combination of Nap-A and TTF-1 is useful in the distinction of primary lung ACA (Nap-A+, TTF-1+) from primary lung squamous cell carcinoma (Nap-A−, TTF-1−) and primary lung small cell carcinoma (Nap-A−, TTF-1+).

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P16ink4a overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix

Human Pathology ◽

10.1016/s0046-8177(03)00284-3 ◽

2003 ◽

Vol 34 (8) ◽

pp. 778-783 ◽

Cited By ~ 74

Author(s):

Nobuo Masumoto ◽

Takuma Fujii ◽

Mitsuya Ishikawa ◽

Miyuki Saito ◽

Takashi Iwata ◽

...

Keyword(s):

Human Papillomavirus ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Small Cell ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy

Case Reports in Oncology ◽

10.1159/000506446 ◽

2020 ◽

Vol 13 (1) ◽

pp. 373-378 ◽

Cited By ~ 1

Author(s):

Yuri Nakao ◽

Satoshi Tamauchi ◽

Nobuhisa Yoshikawa ◽

Shiro Suzuki ◽

Hiroaki Kajiyama ◽

...

Keyword(s):

Lymph Node ◽

Combination Therapy ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Posterior Wall ◽

Complete Response ◽

Uterine Sarcoma ◽

Small Cell ◽

Lymph Node Sampling

We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. The patient was a 62-year-old woman with a chief complaint of irregular vaginal bleeding. Magnetic resonance imaging showed a 10-cm irregular mass from the uterine corpus’s posterior wall to the cervix. Abdominal total hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node sampling were performed for suspected uterine sarcoma. Histopathological findings revealed small cell carcinoma with lymph node metastasis. Although 6 cycles of etoposide + cisplatin were performed, para-aortic lymph node recurrence was found 3 months after chemotherapy. Subsequently, the patient received 8 cycles of TC + Bev, which eliminated the metastases. The patient is currently alive at 24 months.

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