scholarly journals The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Øyvind Helgeland ◽  
Jens K. Hertel ◽  
Anders Molven ◽  
Helge Ræder ◽  
Carl G. P. Platou ◽  
...  
Keyword(s):  
Single Point ◽  
Strong Association ◽  
Population Based ◽  
Risk Haplotype ◽  
Cross Sectional ◽  
Chromosome 9P21 ◽  
Snp Association ◽  
Risk Variants ◽  
Norwegian Population

Background.Two adjacent regions upstreamCDKN2Bon chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream ofCDKN2Btagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2.Results.Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282∣rs10811661: OR = 1.19,P=2.0×10-3) in the region. We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD(P<0.01). Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI,rs2065501  (P=0.03)andrs3217986  (P=0.04).Conclusions.We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region.

scholarly journals Concerns in the Norwegian Population during the Initial Lockdown Due to the COVID-19 Pandemic

2021 ◽  
Vol 18 (11) ◽  
pp. 6119
Author(s):  
Inger Schou-Bredal ◽  
Laila Skogstad ◽  
Tine K. Grimholt ◽  
Tore Bonsaksen ◽  
Øivind Ekeberg ◽  
...  
Keyword(s):  
Online Survey ◽  
Female Gender ◽  
Population Based ◽  
Snowball Sampling ◽  
Financial Loss ◽  
Next Of Kin ◽  
Cross Sectional ◽  
Norwegian Population ◽  
Gender And Age ◽  
Response Alternatives

Although concern affects one’s welfare or happiness, few studies to date have focused on peoples’ concerns during the initial COVID-19 lockdown. The aim of the study was to explore concerns in the Norwegian populations according to gender and age, and identify which concerns were most prominent during the lockdown. A population-based cross-sectional online survey using snowball-sampling strategies was conducted, to which 4527 adults (≥18 years) responded. Questions related to concerns had response alternatives yes or no. In addition, they were asked which concern was most prominent. Nearly all the 4527 respondents (92%) reported that they were concerned: 60.9% were generally concerned about the pandemic, 83.9% were concerned about family and friends, 21.8% had financial concerns, and 25.3% expected financial loss. More women were concerned about family and friends than males, (85.2% vs. 76.2%, p < 0.001), whereas more men expected financial loss (30.4% vs. 24.4%y, p = 0.001). Younger adults (<50 years) had more financial concerns than older adults (25.9% vs. 10.5%, p < 0.001). Being concerned about family and friends was the most prominent concern and was associated with; lower age (OR 0.79), female gender (OR 1.59), and being next of kin (2.42). The most prominent concern for adults 70 years or older was being infected by COVID-19. In conclusion, women and younger individuals were most concerned. While adults under 70 years of age were most concerned about family and friends and adults 70 years or older were most concerned about being infected by COVID-19.

scholarly journals Anemia and functional capacity in elderly Brazilian hospitalized patients

2013 ◽  
Vol 29 (7) ◽  
pp. 1322-1332 ◽  
Author(s):  
Raquel de Macedo Bosco ◽  
Elisa Priscila Souza Assis ◽  
Renata Rosseti Pinheiro ◽  
Luiza Cristina Viana de Queiroz ◽  
Leani S. M. Pereira ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Functional Capacity ◽  
Daily Living ◽  
Strong Association ◽  
Population Based ◽  
Categorical Variables ◽  
Fisher Exact Test ◽  
Cross Sectional ◽  
Belo Horizonte ◽  
The Impact

This study evaluated the association between anemia and physical functional capacity in a cross-sectional population-based sample of 709 hospitalized elderly patients aged 60 years and over admitted to the Madre Teresa Hospital, Belo Horizonte, State of Minas Gerais, Brazil. The Mann-Whitney or "t" test, and chi-square or Fisher exact test were used for quantitative and categorical variables, respectively, and hierarchical binary logistic regression was used to identify significant predictors. The presence of anemia was found in 30% of participants and was significantly associated with decreased functionality according to the two measures which were used - ADL (activities of daily living) and IADL (instrumental activities of daily living). Anemia was also independently associated with older age. The results of this study demonstrate a strong association between the presence of anemia and lower levels of functional capacity. Further investigations are needed to assess the impact of anemia treatment on the functionality and independence of older people.

Dusty trades and associated rheumatoid arthritis in a population-based study in the coal mining counties of Appalachia

2022 ◽  
pp. oemed-2021-107899
Author(s):  
Gabriela Schmajuk ◽  
Laura Trupin ◽  
Edward H Yelin ◽  
Paul D Blanc
Keyword(s):  
Rheumatoid Arthritis ◽  
Coal Mining ◽  
Smoking Status ◽  
Strong Association ◽  
Population Based ◽  
Cross Sectional ◽  
Silica Exposure ◽  
Random Digit Dial ◽  
Ergonomic Exposure ◽  
Ergonomic Exposures

ObjectivesWe previously showed increased coal mining-associated risk of rheumatoid arthritis (RA). Using additional survey data, we sought to delineate this risk further.MethodsWe used data from two cross-sectional, random-digit-dial, population-based surveys (males;≥50 years) in selected counties in the Appalachian region of the inland, mid-Atlantic USA with elevated pneumoconiosis mortality. Surveys ascertained age, smoking, coal mining and non-coal silica exposure jobs. In a subset, we surveyed ergonomic exposures, scored by intensity. We queried diagnosis of RA, corticosteroid use, and, in a subset, use of disease modifying antirheumatic drugs (DMARDs). Multivariable logistic regression modelled RA risk (defined by glucocorticoid or DMARDs use) associated with coal mining employment, other silica exposure, smoking status, and age and ergonomic exposures.ResultsWe analysed data for 2981 survey respondents (mean age 66.6 years; 15% current, 44% ex-smokers). The prevalence of glucocorticoid-treated and DMARD-treated RA was 11% and 4%, respectively. Glucocorticoid-treated RA was associated with coal mining (OR 3.5; 95% CI 2.5 to 4.9) and non-coal mining silica exposure (OR 3.2; 95% CI 2.4 to 4.4). For DMARD-treated RA, the odds associated with coal mining and other silica remained elevated: OR 2.3 (95% CI 1.18, 4.5) and OR 2.7 (95% CI 1.51, 5.0), respectively. In the same model, the highest intensity ergonomic exposure also was associated with increased odds of RA (OR 4.3; 95% CI 1.96 to 9.6).ConclusionsWe observed a strong association between coal mining and other silica-exposing dusty trades and RA. Clinicians and insurers should consider occupational histories in the aetiology of RA.

scholarly journals Suicidal ideation in relation to disordered eating, body size and weight perception: a cross-sectional study of a Norwegian adolescent population: the HUNT Study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e029809 ◽  
Author(s):  
Farzaneh Saeedzadeh Sardahaee ◽  
Turid Lingaas Holmen ◽  
Nadia Micali ◽  
Erik R Sund ◽  
Ottar Bjerkeset ◽  
...  
Keyword(s):  
Body Size ◽  
Suicidal Ideation ◽  
Disordered Eating ◽  
Weight Perception ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Norwegian Population ◽  
Hunt Study

ObjectiveWe conducted a population-based study on a sample of more than 7000 adolescents where we examined the associations between suicidal ideation (SI) and disordered eating (DE) and its related traits.DesignCross-sectional.SettingsData were derived from two Norwegian population-based cohorts, the Young-HUNT1 (1995–1997) and Young-HUNT3 (2006–2008) from the county of Nord-Trøndelag, Norway.ParticipantsA total of 7268 adolescents (15–19 years) who had completed self-reported questionnaires including items on SI, DE, body size and weight perception were included.Primary outcome measuresORs for SI given DE, body size or weight perception. Analyses were performed in multivariate logistic regression models.ResultsThe prevalence of SI was 23.1% in total population. Both girls and boys who reported DE, evaluated their body size asnot‘about the same as others’ or were ‘unhappy about their weight’ had between twofold to fivefold increase in odds for SI; these incremental risks were observed independent of sex, age, body mass index and socioeconomic status. We observed higher odds for SI among boys.ConclusionsOur findings suggest a clear association between SI and DE and its associated traits, in both genders but especially in males. Special attention should be paid on early detection of DE traits among adolescents.

Co- and multimorbidity patterns in an unselected Norwegian population: cross-sectional analysis based on the HUNT Study and theoretical reflections concerning basic medical models

2014 ◽  
Vol 2 (3) ◽  
pp. 335 ◽  
Author(s):  
Margret Olafia Tomasdottir ◽  
Linn Getz ◽  
Johann A Sigurdsson ◽  
Halfdan Petursson ◽  
Anna Luise Kirkengen ◽  
...  
Keyword(s):  
Allostatic Load ◽  
Age Groups ◽  
Population Based ◽  
Health Study ◽  
Cross Sectional ◽  
Disease Clusters ◽  
Diagnostic Categories ◽  
Norwegian Population ◽  
Somatic Diseases ◽  
Sectional Analysis

Rationale and aims: Accumulating evidence shows that diseases tend to cluster in diseased individuals, so-called multimorbidity. The aim of this study was to analyze multimorbidity patterns, empirically and theoretically, to better understand the phenomenon. Population and methods: The Norwegian population-based Nord-Trøndelag Health Study HUNT 3 (2006-8), with 47,959 individuals aged 20-79 years. A total of 21 relevant, longstanding diseases/malfunctions were eligible for counting in each participant. Multimorbidity was defined as two or more chronic conditions.Results: Multimorbidity was found in 18% of individuals aged 20 years. The prevalence increased with age in both sexes. The overall age-standardized prevalence was 42% (39% for men, 46% for women). ‘Musculoskeletal disorders’ was the disease-group most frequently associated with multimorbidity. Three conditions, strategically selected to represent different diagnostic domains according to biomedical tradition; gastro-esophageal reflux, thyroid disease and dental problems, were all associated with both mental and somatic comorbid conditions. Conclusions and implications: Multimorbidity appears to be prevalent in both genders and across age-groups, even in the affluent and relatively equitable Norwegian society. The disease clusters typically transcend biomedicine’s traditional demarcations between mental and somatic diseases and between diagnostic categories within each of these domains. A new theoretical approach to disease development and recovery is warranted, in order to adequately tackle ‘the challenge of multimorbidity’, both empirically and clinically. We think the concept allostatic load can be systematically developed to “capture” the interrelatedness of biography and biology and to address the fundamental significance of “that, which gains” versus “that, which drains” any given human being.

scholarly journals Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Patrice Carter ◽  
Danielle H. Bodicoat ◽  
Lauren M. Quinn ◽  
Francesco Zaccardi ◽  
David R. Webb ◽  
...  
Keyword(s):  
Population Based ◽  
Glucose Regulation ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Screening Study ◽  
Multiethnic Population ◽  
Baseline Characteristics ◽  
Sectional Analysis

Introduction. Previous observational studies have shown conflicting results between plasma K+concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+and glucose regulation within a UK multiethnic population.Methods. Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40 and 75 years if White European or 25 and 75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+quartiles were conducted using linear regression models.Results. Data showed individuals in the lowest K+quartile had significantly greater 2-hour glucose levels (0.53 mmol/L, 95% CI: 0.36 to 0.70,P≤0.001) than those in the highest K+quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+quartile had a 0.14% lower HbA1c (95% CI −0.19 to −0.10:P≤0.001) compared to those in the highest K+quartile.Conclusion. This cross-sectional analysis demonstrated that lower K+was associated with greater 2 hr glucose. The data supports the possibility that K+may influence glucose regulation and further research is warranted.

scholarly journals Relevance of anthropometric measurements as predictors of prevalent diabetes type 2: a cross-sectional study on a Norwegian population

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e046162
Author(s):  
Anton Hasselgren ◽  
Biraj Man Karmacharya ◽  
Ann-Katrin Stensdotter
Keyword(s):  
Diabetes Mellitus ◽  
Outcome Measures ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Secondary Outcome ◽  
Anthropometric Indices ◽  
Cross Sectional ◽  
Norwegian Population ◽  
Potential Association

ObjectivesThe objective was to determine the predictive potential of anthropometric indices to screen prevalent diabetes mellitus type 2 in a Norwegian population.DesignThis is a cross-sectional design to determine the potential association of waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), waist circumference (WC) and body mass index (BMI) with prevalent diabetes mellitus type 2 through logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine the predictive potential of the anthropometric indices. Youden’s index was applied to determine the optimal cut-off points for each anthropometric index.SettingThis study used cross-sectional data from the populations-based Health Study in Nord-Trøndelag which invited all citizens in the county above 20 years of age.ParticipantsThis study included all those who were non-pregnant and had complete data (N=50 042), 98.5% of the participants. The sample is to be considered representative for the population of Norway.Primary and secondary outcome measuresOR and ROC of the potential association between diabetes mellitus type 2 and anthropometric indices were the main planned and performed outcome measures.ResultsThe results suggest that the anthropometric indices performed differently within the Norwegian population with WHR and WHtR being the stronger predictor with (ROC) of 0.746 (0.735 to 0.757) and 0.741 (0.730 to 0.752). The predictive potential for the investigated anthropometric indices was generally stronger for women than men.ConclusionAnthropometric indices of size BMI and the highly correlated WC are less associated with prevalent diabetes mellitus type 2 than WHR (WC adjusted for hip circumference) or WHtR (WC adjusted for height) in a Norwegian population.

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