scholarly journals Effects of Concurrent Training on Oxidative Stress and Insulin Resistance in Obese Individuals

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Niara da Silva Medeiros ◽  
Fabiana Guichard de Abreu ◽  
Alana Schraiber Colato ◽  
Leandro Silva de Lemos ◽  
Thiago Rozales Ramis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Body Weight ◽  
Oxidative Damage ◽  
Body Fat ◽  
Moderate Intensity ◽  
Concurrent Training ◽  
Tbars Level ◽  
Anthropometric Parameters ◽  
And Oxidative Stress

Obesity is associated with insulin resistance (IR) and increased oxidative stress. Thus, the present study aimed to evaluate anthropometric parameters, IR, and oxidative stress in obese individuals subjected to two types of concurrent training at the same intensity but differing in frequency. Accordingly, 25 individuals were divided into two groups: concurrent training 1 (CT1) (5 d/wk) and concurrent training 2 (CT2) (3 d/wk), both with moderate intensity. Anthropometric parameters, IR, and oxidative stress were analyzed before and after 26 sessions of training. Both groups had reduced body weight and body mass index (P<0.05), but only CT1 showed lower body fat percentage and increased basal metabolic rate (P<0.05). Moreover, CT1 had increased HOMA-IR and decreased protein damage (carbonyl level), and CT2 had decreased HOMA-IR and increased lipid peroxidation (TBARS level) (P<0.05). On the other hand, both training protocols reduced the GPx activity. It can be concluded that both types of concurrent training could be an alternative for lowering body weight and BMI. Also, it was observed that concurrent training, depending on the frequency, can contribute to reducing body fat, oxidative damage (protein oxidation), and IR but can induce oxidative damage to lipids. More studies are needed to elucidate the mechanisms involved.

PP184 CHANGES IN ANTHROPOMETRIC PARAMETERS, INSULIN RESISTANCE AND OXIDATIVE STRESS IN MORBIDLY OBESE PATIENTS AFTER BARIATRIC SURGERY

2010 ◽  
Vol 5 (2) ◽  
pp. 95
Author(s):  
J.M. Garcia-Almeida ◽  
M. Murri-Pierri ◽  
E. Garcia-Fuentes ◽  
D. Fernandez-Garcia ◽  
L. Garrido-Sanchez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Anthropometric Parameters ◽  
And Oxidative Stress

scholarly journals Bark of Passiflora edulis Treatment Stimulates Antioxidant Capacity, and Reduces Dyslipidemia and Body Fat in db/db Mice

Antioxidants ◽  
2018 ◽  
Vol 7 (9) ◽  
pp. 120 ◽  
Author(s):  
Marielle Panelli ◽  
Damiana Pierine ◽  
Sérgio de Souza ◽  
Artur Ferron ◽  
Jéssica Garcia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Composition ◽  
Body Weight ◽  
Antioxidant Capacity ◽  
Body Fat ◽  
Subcutaneous Fat ◽  
Trigger Factor ◽  
Obese Mice ◽  
Passiflora Edulis ◽  
And Oxidative Stress

Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p < 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice.

Effects of topical capsaicin combined with moderate exercise on insulin resistance, body weight and oxidative stress in hypoestrogenic obese rats

2017 ◽  
Vol 41 (5) ◽  
pp. 750-758 ◽  
Author(s):  
J M L Medina-Contreras ◽  
J Colado-Velázquez ◽  
N L Gómez-Viquez ◽  
P Mailloux-Salinas ◽  
I Pérez-Torres ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Body Weight ◽  
Moderate Exercise ◽  
Obese Rats ◽  
Topical Capsaicin ◽  
And Oxidative Stress

Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Jennifer Chidera Awurum ◽  
Sunday Amos Onikanni ◽  
Adedotun Adefolalu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Role ◽  
Diabetic Rats ◽  
Gene Expressions ◽  
Ki 67 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

scholarly journals Effects of Dietary β-Mannanase Supplementation on Growth Performance, Apparent Total Tract Digestibility, Intestinal Integrity, and Immune Responses in Weaning Pigs

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 703
Author(s):  
Jae-Cheol Jang ◽  
Kwang Kim ◽  
Young Jang ◽  
Yoo Kim
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Growth Performance ◽  
Basal Diet ◽  
Villus Height ◽  
Crypt Depth ◽  
Intestinal Integrity ◽  
Weaning Pigs ◽  
Dietary Treatments ◽  
And Oxidative Stress

The experiment aimed to investigate the effects of dietary β-mannanase supplementation on growth performance, apparent total tract digestibility (ATTD) of nutrients, intestinal integrity, and the immunological and oxidative stress parameters in weaning pigs. A total of 64 newly weaning pigs (initial body weight: 6.96 ± 0.70 kg) were allotted to two dietary treatments in eight replicates per treatment with four pigs per pen based on body weight and sex. Dietary treatments were 1.) CON (control: corn-soybean meal based basal diet) and 2.) β-mannanase (basal diet +0.06% β-mannanase). The β-mannanase supplementation did not affect growth performance, concentrations of acute phase protein, superoxide dismutase and glutathione peroxidase. However, the pigs fed the β-mannanase-supplemented diet had greater ATTD of ether extract, jejunum villus height, and villus height-to-crypt depth ratio, and lower crypt depth compared with those fed the CON diet (p < 0.05). The pigs fed the β-mannanase-supplemented diet tended to have the lower count of E. coli in cecum than those fed the CON diet (p = 0.08). In conclusion, dietary β-mannanase supplementation did not affect growth performance, immune response and oxidative stress of weaning pigs, whereas it increased fat digestibility and had positive effects on intestinal integrity and cecum microflora by reducing the count of E.coli.

scholarly journals Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat

1970 ◽  
Vol 36 (1) ◽  
pp. 14-19
Author(s):  
Md. Zakirul Islam ◽  
Md. Sayedur Rahman
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Low Dose ◽  
Rat Aorta ◽  
Antioxidant Effect ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
Cholesterol Feeding ◽  
Atherosclerotic Change ◽  
And Oxidative Stress

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, losartan showed anti-atherogenic activity reflected by hypolipidemic effect and antioxidant effect in erythrocyte. This activity was abolished by addition of hydrochlorothiazide with losartan but remained unaltered by addition of indapamide with losartan. Atherosclerotic change and oxidative stress were not found in rat aorta, which may be due to short duration and low dose of cholesterol feeding. Hydrochlorothiazide treatment was associated with hypokalemia, which was not present in losartan or indapamide treatment. This study suggests that indapamide might be co-administered with losartan conserving the essential anti-atherogenic potential of losartan.Online: 13 July 2010DOI: http://dx.doi.org/10.3329/bmrcb.v36i1.5447Bangladesh Med Res Counc Bull 2010; 36: 14-19   

Prolonged Low-moderate Intensity Exercise On Physiological Markers Of Metabolic And Oxidative Stress

2018 ◽  
Vol 50 (5S) ◽  
pp. 248-249
Author(s):  
Dominique Gagnon ◽  
Sandra Dorman ◽  
Stephen Ritchie ◽  
Shivaprakash Jagalur Mutt ◽  
Ville Stenbäck ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Physiological Markers ◽  
And Oxidative Stress

scholarly journals Association of Sympathovagal Imbalance with Cognitive Deficit, Insulin Resistance and Oxidative Stress in Newly Diagnosed Hypertension

2019 ◽  
Vol 5 (3) ◽  
pp. 145-150
Author(s):  
Subathra Thiruchengodu Ammaiyappan ◽  
Gopal Krushna Pal ◽  
Dhanalakshmi Yerrabelli ◽  
Pravati Pal ◽  
Nivedita Nanda
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Cognitive Deficit ◽  
Newly Diagnosed ◽  
Sympathovagal Imbalance ◽  
And Oxidative Stress

Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score

2018 ◽  
Vol 33 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Branko Srećković ◽  
Ivan Soldatovic ◽  
Emina Colak ◽  
Igor Mrdovic ◽  
Mirjana Sumarac-Dumanovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Risk Score ◽  
Continuous Measure ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Apo B ◽  
Significant Difference ◽  
Homeostatic Model Assessment

Abstract Background: Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative stress causes endothelial dysfunction, hypertension and atherosclerosis. The objective of the study was to examine the correlation of homocysteine with siMS score and siMS risk score and with other MS co-founding factors. Methods: The study included 69 obese individuals (age over 30, body mass index [BMI] >25 kg/m2), classified into two groups: I-with MS (33 patients); II-without MS (36 patients). Measurements included: anthropometric parameters, lipids, glucose regulation parameters and inflammation parameters. IR was determined by homeostatic model assessment for insulin resistance (HOMA-IR). ATP III classification was applied for diagnosing MS. SiMS score was used as continuous measure of metabolic syndrome. Results: A significant difference between groups was found for C-reactive protein (CRP) (p<0.01) apolipoprotein (Apo) B, HOMA-IR and acidum uricum (p<0.05). siMS risk score showed a positive correlation with homocysteine (p=0.023), while siMS score correlated positively with fibrinogen (p=0.013), CRP and acidum uricum (p=0.000) and homocysteine (p=0.08). Homocysteine correlated positively with ApoB (p=0.036), HbA1c (p=0.047), HOMA-IR (p=0.008) and negatively with ApoE (p=0.042). Conclusions: Correlation of siMS score with homocysteine, fibrinogen, CRP and acidum uricum indicates that they are co-founding factors of MS. siMS risk score correlation with homocysteine indicates that hyperhomocysteinemia increases with age. Hyperhomocysteinemia is linked with genetic factors and family nutritional scheme, increasing the risk for atherosclerosis.

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