Antiperoxidative Activity ofTetracarpidium conophorumLeaf Extract in Reproductive Organs of Male Rats

Tetracarpidium conophorum(Mull. Arg.) Hutch. & Dalz is one of the many medicinal plants used in folklore as male fertility enhancers. This research was aimed at evaluating the anti-peroxidative activity of the leaves of this plant by determining their capacity to reduce malondialdehyde (MDA) level in reproductive organs and accessory glands of rats. Adult male rats were administered orally with the aqueous leaf extract fromT. conophorumat 50, 500 and 1000 mg/kg body weight for 21 consecutive days while clomiphene citrate (1.04 mg/kg body weight), a fertility drug was used as standard. The results of the study indicated that there was increase in relative organ weight, body weight, mean total food and water consumed by the treated groups. Testicular MDA level was highly significantly different from that of the control (p<0.0001) although a tentatively decreased MDA level was observed. However, MDA levels in the reproductive accessory glands, epididymis, seminal vesicle and prostate gland were insignificantly (p<0.05) lower than those of controls. The highest percentage decrease of MDA level (66.35, 42.68, 62.50 and 63.36%) was observed at the highest concentration of the extract (1000 mg/kg) in the testis, epididymis, seminal vesicle and prostate gland respectively. These values were two-fold greater than the values obtained for the standard drug. Interestingly, the treatment of rats with the extract significantly increased the activities of superoxide dismutase, catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and the levels of GSH, vitamin C and total protein. Collectively, the results suggest that the extract fromT. conophorumleaves had greater capacity to reduce lipid peroxidation in reproductive organs and accessory glands and thus, this plant may be useful in the treatment/management of reproductive cellular damage involving reactive oxygen species.

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Characterization of the effects of clomiphene citrate on reproductive physiology in male rats of various ages

Acta Endocrinologica ◽

10.1530/acta.0.1180437 ◽

1988 ◽

Vol 118 (3) ◽

pp. 437-443 ◽

Cited By ~ 6

Author(s):

Janine L. Brown ◽

Prabir K. Chakraborty

Keyword(s):

Seminal Vesicle ◽

Clomiphene Citrate ◽

Prostate Gland ◽

Age Groups ◽

Reproductive Function ◽

Male Rats ◽

Testis Weight ◽

Lh Receptor ◽

Serum Lh ◽

Prepubertal Rats

Abstract. Clomiphene citrate (clomiphene) inhibits reproduction in male rats; however, stimulatory effects have been reported at low doses. Male rats were implanted at 60 (adult), 35 (peripubertal) or 10 (prepubertal) days of age with pellets that delivered 0,0.05, 0.5 or 5.0 mg clomiphene · kg−1 · day−1 and were sacrificed after 7 or 14 days of treatment. Testis weight was unaffected by clomiphene in adult and peripubertal rats, but was reduced by all doses in prepubertal rats. Seminal vesicle and prostate gland weights were decreased to varying degrees by clomiphene in all animals, except seminal vesicle weight in peripubertal rats. Serum LH and testosterone were decreased by most doses in all age groups, whereas pituitary LH was decreased in prepubertal rats only. Pituitary GnRH and testicular LH receptor concentrations were reduced in all treated animals. Serum and pituitary FSH were decreased in pre- and peripubertal rats, whereas testicular FSH receptor concentrations were unaffected by treatment. In summary, 1) reproductive function was compromised by clomiphene and many responses were age-dependent, 2) reductions in gonadotropins suggest that clomiphene decreased their synthesis and/or release, and 3) decreased serum LH and testicular LH receptor concentrations were coupled to reduced testosterone secretion.

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Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

Human & Experimental Toxicology ◽

10.1177/09603271211013448 ◽

2021 ◽

pp. 096032712110134

Author(s):

O Zouaoui ◽

K Adouni ◽

A Jelled ◽

A Thouri ◽

A Ben Chrifa ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Body Weight ◽

Diabetes Type 2 ◽

Male Rats ◽

Control Group ◽

Standard Drug ◽

High Fructose ◽

Group A ◽

Histological Architecture

Phytochemical composition and antioxidant activity of flowers decoction at post-flowering stage (F3D) of Opuntia dejecta were determined. The obtained findings demonstrate that F3D has a marked antioxidant activity in all tested assays. Furthermore, the present study was designed to test the protective activity of F3D against induced Diabetes type 2 (DT2) in male rats. Those metabolic syndromes were induced by a high-fructose diet (HFD) (10% fructose solution) for a period of 20 weeks. F3D was administered orally (100 and 300 mg/kg body weight) daily for the last 4 weeks. Metformin (150 mg/kg body weight) was used as a standard drug and administrated orally for the last 4 weeks. The results showed a significant increase in blood glucose, triglycerides and hepatic markers (ALAT, ASAT and ALK-P) in HFD group. A significant increase in hepatic TBARS and a significant decrease in SOD, CAT and GPX were observed in fructose fed rats compared to control group. Administration of F3D showed a protective effect in biochemical and oxidative stress parameters measured in this study. Also, oral administration of F3D restored the histological architecture of rat liver in comparison with rats fed HFD. In conclusion, F3D attenuated hepatic oxidative stress in fructose-fed rats.

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THE REPRODUCTIVE ORGANS OF THE VELVET MITE, ALLOTHROMBIUM LEROUXI (TROMBIDIFORMES: TROMBIDIIDAE)

The Canadian Entomologist ◽

10.4039/ent102144-2 ◽

1970 ◽

Vol 102 (2) ◽

pp. 144-157 ◽

Cited By ~ 5

Author(s):

S. N. Mathur ◽

E. J. LeRoux

Keyword(s):

Seminal Vesicle ◽

Ejaculatory Duct ◽

Reproductive Organs ◽

Accessory Gland ◽

Male And Female ◽

Accessory Glands ◽

Receptaculum Seminis ◽

Female Reproductive Organs

AbstractThe anatomy and functions of the male and female reproductive organs of Allothrombium lerouxi Moss are described in detail. In the male, the reproductive organs consist of paired testes, paired vasa diferentia, a median seminal vesicle, a median ejaculatory duct, bursa expulsatoria, a penis, and a median accessory gland; in the female, they consist of paired ovaries, paired oviducts, a median uterus and a vagina. The function of the parts in the male differs from that reported in other species of Trombidiformes, and in females fertilization takes place in the spongy epithelium of the uterus instead of in the oviducts as in oribatids. Females also lack a receptaculum seminis and accessory glands.

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THE COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-OL-3-ONE PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

Journal of Endocrinology ◽

10.1677/joe.0.0510241 ◽

1971 ◽

Vol 51 (2) ◽

pp. 241-NP ◽

Cited By ~ 96

Author(s):

H. H. FEDER

Keyword(s):

Body Weight ◽

Seminal Vesicle ◽

Sexual Behaviour ◽

Testosterone Propionate ◽

Reproductive Behaviour ◽

Male Rats ◽

Male Sexual Behaviour ◽

Testicular Weight ◽

Seminal Vesicle Weight ◽

Experienced Adult

SUMMARY 5α-Androstan-17β-ol-3-one in its free or in its propionate form was injected systemically (125 μg/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight. In contrast, testosterone propionate (125 μg/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males. These effects may have been due in part to conversion of testosterone to 5α-androstan-17β-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

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EFFECT OF POLYDIETHYLSTILBOESTROL PHOSPHATE ON THE PITUITARY CONTENT OF FSH AND ICSH IN MALE RATS

Acta Endocrinologica ◽

10.1530/acta.0.0610449 ◽

1969 ◽

Vol 61 (3) ◽

pp. 449-460 ◽

Cited By ~ 2

Author(s):

Torsten Perklev ◽

Yngve Gröning

Keyword(s):

Body Weight ◽

Interstitial Cell ◽

The Body ◽

Male Rats ◽

Inhibiting Effect ◽

Accessory Glands ◽

Complete Restoration ◽

Body Weights ◽

Human Menopausal Gonadotrophin ◽

Stimulating Hormone

ABSTRACT The effect of a single dose of polydiethylstilboestrol phosphate (PSP) on the pituitary content of follicle stimulating hormone (FSH) and interstitial cell stimulating hormone (ICSH) was studied in intact, adult male rats after 7, 28, 103 and 161 days, respectively. The body weight and different organ weights were also recorded. The results were compared with those obtained in untreated controls and in rats treated with daily doses of diethylstilboestrol (DES) for 7 days. The pituitary FSH and ICSH content in the control rats decreased roughly to about half during a period of approximately 5 months, i. e. from the 2nd to the 7th month of life. PSP (400 μg/100 g body weight) and DES (320 μg/100 g body weight) reduced the pituitary content of FSH and ICSH to approximately 35 and 50% of the control values, respectively, measured on the 7th day of treatment. The gonadotrophin inhibiting effect of PSP lasted for more than 103 days. On the other hand, on Day 28 the pituitary content of ICSH was normal and that of FSH significantly elevated in the DES-treated rats. On Day 161 both PSP- and DES-treated animals had a significantly increased ICSH content, while the FSH content was normal. Body weights, as well as the weights of the testes and accessory glands were reduced both by DES and PSP as early as on the 7th day after the commencement of treatment. Complete restoration of these parameters in DES-treated animals was found on Day 103, while PSP exerted its effect for more than 161 days. Daily injections of 3 IU of FSH and 1.5 IU of ICSH administered in the form of human menopausal gonadotrophin (HMG) to PSP-treated rats from the day of PSP injection for 14 days counteracted the weight loss of the testes and accessory glands, as well as the loss of body weight and the reduced food intake. The hypertrophy of the adrenals and the sterility produced by the administration of PSP were completely prevented by HMG injections.

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Anti dyslipidemic effect of Ficus Carica Fruit (Fig) on Lipid Profile of Diet Induced Hyperlipidemic Rats

10.53350/pjmhs211571709 ◽

2021 ◽

Vol 15 (7) ◽

pp. 1709-1712

Author(s):

Fouzia Perveen ◽

Fariha Ahmad Khan ◽

Zoobia Irum ◽

Amir Hassan Siddiqui ◽

Maira Bhatti ◽

...

Keyword(s):

Body Weight ◽

Cardiovascular Diseases ◽

Lipid Profile ◽

High Fat Diet ◽

Fatal Outcome ◽

Ficus Carica ◽

Male Rats ◽

High Fat ◽

Standard Drug ◽

Study Results

Back ground: Hyperlipidaemia, characterized by elevation of one or more lipid types in blood, is a major risk factor for cardiovascular diseases and stroke. Management of hyperlipidaemia is helpful to control the fatal outcome of cardiovascular diseases. This experimental study was done to observe the effects of pulp of Ficus carica fruit on lipid profile in induced hyperlipidemic rats in comparison to atorvastatin. Methodology: The duration of study was 12 weeks. In this study forty male rats were taken and divided into four groups. One group was normal control which was given normal diet throughout study period of 12 weeks. The second group was positive control which was given high fat diet for 12 weeks. The remaining two groups were experimental groups which were given high fat diet for 12 weeks. Hyperlipidaemia was induced after giving high fat diet for first four weeks to the experimental groups. The pulp of Ficus carica fruit and atorvastatin was then added to diet of two experimental groups respectively in addition to high fat diet for the next 8 weeks. Body weight, fasting lipid profile, LDL/HDL ratio and AIP were measured at baseline, 4th, 8th, and 12th week of study. Results: Pulp of Ficus carica fruit significantly improved fasting lipid profile, AIP and LDL/HDL ratio. HDL was also significantly increased. However there was no change in body weight. Conclusion: Ficus carica fruit has marked antihyperlipidemic properties comparable to standard drug atorvastatin. Key words: Hyperlipidaemia, ethanolic extract, pulp, Ficus carica

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The effect of paclitaxel (taxol) on the reproductive system and the semen parameters as well as on other organs of male rats.

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15403 ◽

2018 ◽

Vol 52 (1) ◽

pp. 23 ◽

Cited By ~ 3

Author(s):

G. KOEHLER-SAMOUILIDOU (ΓΚ. ΚΕΛΕΡ-ΣΑΜΟΥΗΛΙΔΟΥ) ◽

E. KALDRYMIDOU (Ε. ΚΑΛΔΡΥΜΙΔΟΥ) ◽

N. PAPAIOANNOU (Ν. ΠΑΠΑΪΩΑΝΝΟΥ) ◽

V. P. KOTSAKI-KOVATSI (Β-Π. ΚΩΤΣΑΚΗ-ΚΟΒΑΤΣΗ) ◽

A. VADARAKIS (Α. ΒΑΝΤΑΡΑΚΗΣ)

Keyword(s):

Leydig Cells ◽

Prostate Gland ◽

Test Group ◽

Reproductive Organs ◽

Male Rats ◽

Semen Parameters ◽

Test Animal ◽

Dividing Cells ◽

Old Rats ◽

Histiocytic Infiltration

The effect of the administration of paclitaxel on the male reproductive organs as well as on several semen parameters and other organs of Wis tar rats was studied. To 14 weeks old rats 12,4 mg paclitaxel/kg b.w.were administered i.p. once a week for 4 weeks. Six days after the last injection of paclitaxel ten animals, five (n=5) test (group Al) and five control animals (group A2) were sacrificed. Another ten animals, five (n=5) test (group Bl) and five (n=5) control animals (group B2) were sacrificed eleven weeks after the last injection of paclitaxel. The weights of the testes, the epididymis and the prostate gland of the test animals (group Al) were decreased as compared to the control animals (group A2). The number and the motility of the test animal spermatozoa were decreased, and many of them were abnormal. Histologically, the dividing cells and round spermatids were most affected. Leydig cells appeared degenerated. The epithelium of the ductucs epididymis was cuboidal and cell microvilli were absent. There was infiltration of neutrophils. The prostate gland was cystic with degeneration and desquamation of the epithelial cells. In the adrenals cellular degeneration and histiocytic infiltration were observed. In the spleen myeloid metaplasis and in the liver local allergic reaction around the interlobular bile ducts were observed. The weights of the testes, the epididymis and the prostate glands of the test animals (group Bl) were normal as compared with the control animals (group B2). The sperm motility was also normal but the number of spermatozoa was still decreased as compared with the control animals (group B2). Histologically, all examined organs were similar to those of the control animals.

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Effects of Tetracycline on Body Weight and Accessory Reproduc-tive Organ Weights (Prostate Gland and Seminal Vesicle) of Adult Male Wistar Rats

Health Care ◽

10.12966/hc.05.06.2014 ◽

2014 ◽

Vol 2 (2) ◽

pp. 47

Author(s):

Popoola Oladele Biliamin ◽

Ajayi Ruth Taiwo ◽

Akinyemi Raphael Akinsola ◽

Oguntoye Shemilore Gbenga ◽

Huthman Ibrahim Oluwaseun

Keyword(s):

Body Weight ◽

Seminal Vesicle ◽

Adult Male ◽

Wistar Rats ◽

Prostate Gland ◽

Organ Weights ◽

Male Wistar Rats

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Effects of prenatal administration of mestranol and two progestins on testosterone synthesis and reproductive tract development in male rats

Acta Endocrinologica ◽

10.1530/acta.0.1160193 ◽

1987 ◽

Vol 116 (2) ◽

pp. 193-199 ◽

Cited By ~ 3

Author(s):

Santosh K. Varma ◽

Eric Bloch

Keyword(s):

Body Weight ◽

Seminal Vesicle ◽

Medroxyprogesterone Acetate ◽

Placental Tissue ◽

Endocrine Function ◽

Male Rats ◽

Ventral Prostate ◽

Pregnant Rats ◽

Testosterone Synthesis

Abstract. The oestrogen mestranol (0, 0.01, 0.1 mg/kg body weight per day) and the progestins medroxyprogesterone-acetate and norethisterone (0, 2, 20 mg/kg body weight per day each) in sesame oil were intubated intragastrically daily during gestational days 14.5 through 19.5 to pregnant rats. Males were studied as 20.5-day-old foetuses and 4-month-old adults for serum testosterone and LH concentrations, in vitro testosterone synthesis, anogenital distance (foetuses only) and testes, seminal vesicle and ventral prostate weights. Administration of 0.1 mg mestranol decreased by 35 to 70% basal and LH-stimulated testosterone synthesis by both foetal and adult testes in vitro (P < 0.01). Foetal body weights (P < 0.05), but not anogenital distances, were significantly decreased. Testosterone content in adult sera was reduced significantly (P < 0.05) to less than 50% of control. Testes, ventral prostate, seminal vesicle and epididymal weights were unaffected by treatment. Medroxyprogesterone acetate or norethisterone administration did not alter testes endocrine function in foetal or adult offspring. In a small number of rats, pregnant for 10.5, 14.5 or 18.5 days, [3H]ethinyloestradiol was intubated and foetal and placental tissue examined for appearance and content of radioactivity. Radioactivity was detected in 10.5, 14.5 and 18.5 days old placentas, and 14.5 and 18.5 days old foetal liver, gonads and external genitalia. With [3H]medroxyprogesterone acetate, radioactivity was localized in 14.5 day placenta and foetal tissues. Thin-layer chromatographic analysis showed most of the activity to migrate as authentic ethinyloestradiol or medroxyprogesterone acetate. The results demonstrate inhibition of testicular testosterone synthesis by mestranol, presumably by being transferred across the placenta and acting in the foetus. The diminished activity of adult testes indicates a permanent effect of in utero mestranol exposure on testes function.

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Sexual selection affects the sizes of the mammalian prostate gland and seminal vesicles

Current Zoology ◽

10.1093/czoolo/55.1.1 ◽

2009 ◽

Vol 55 (1) ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Matthew J. Anderson ◽

Alan F . Dixson

Keyword(s):

Body Weight ◽

Sexual Selection ◽

Prostate Gland ◽

Morphological Diversity ◽

Seminal Vesicles ◽

Data Set ◽

Chemical Complexity ◽

Accessory Glands ◽

Accessory Reproductive Glands ◽

Testes Size

Abstract The accessory reproductive glands of male mammals contribute the bulk of the secretions in which spermatozoa are transported to the female tract during copulation. Despite their morphological diversity, and the chemical complexity of their products, little is known about the possible effects of sexual selection upon these glands in mammals. Here we consider the seminal vesicles and prostate glands in a sample of 89 species and 60 genera representing 8 Orders of mammals. The sizes of the accessory glands are analysed in relation to body weight and testes weight. Both the seminal vesicles size and prostate size (corrected for body weight) correlate positively with relative testes size in this sample; this finding remains highly significant after application of procedures to correct for possible phylogenetic biases in the data set. The accessory reproductive glands are also significantly larger in those mammals which have large relative testes sizes, and in which the likelihood of sperm competition is greatest. These results support the hypothesis that sexual selection has played an important role in the evolution of the mammalian prostate gland and seminal vesicles.

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