Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure.Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM.Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos.Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.

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Dose–response relationship between inorganic arsenic exposure and lung cancer among arseniasis area residents with low methylation capacity: A population-based cohort study

European Journal of Cancer ◽

10.1016/s0959-8049(16)61545-9 ◽

2016 ◽

Vol 61 ◽

pp. S154

Author(s):

P.J. Liao ◽

K.H. Hsu

Keyword(s):

Lung Cancer ◽

Cohort Study ◽

Dose Response ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Population Based ◽

Response Relationship ◽

Dose Response Relationship ◽

Methylation Capacity

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Faculty Opinions recommendation of Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13741.471237 ◽

2006 ◽

Author(s):

Paolo Vineis

Keyword(s):

Lung Cancer ◽

Dose Response ◽

Response Relationship ◽

Dose Response Relationship ◽

Cooking Fumes

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Sa1789 – Dose–Response Relationship Between Cigarette Smoking and Ulcerative Colitis : A Nationwide Population-Based Study

Gastroenterology ◽

10.1016/s0016-5085(19)37856-4 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-403

Author(s):

Seona Park ◽

Jaeyoung Chun ◽

Kyungdo Han ◽

Hosim Soh ◽

Eun Ae Kang ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cigarette Smoking ◽

Dose Response ◽

Population Based ◽

Response Relationship ◽

Dose Response Relationship ◽

Population Based Study

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Maternal occupational exposure to solvents and gastroschisis in offspring - National Birth Defects Prevention Study 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2019-106147 ◽

2020 ◽

Vol 77 (3) ◽

pp. 172-178 ◽

Cited By ~ 1

Author(s):

Nynke Spinder ◽

Lynn M Almli ◽

Tania A Desrosiers ◽

Kathryn E Arnold ◽

Jorieke E H Bergman ◽

...

Keyword(s):

Occupational Exposure ◽

Birth Defects ◽

Maternal Age ◽

Large Population ◽

First Trimester ◽

Population Based ◽

Cumulative Exposure ◽

Surveillance Systems ◽

Prevention Study ◽

Solvent Exposure

ObjectivesThe aim of this study was to assess the association between maternal occupational exposure to solvents and gastroschisis in offspring.MethodsWe used data from the National Birth Defects Prevention Study, a large population-based case-control study of major birth defects conducted in 10 US states from 1997 to 2011. Infants with gastroschisis were ascertained by active birth defects surveillance systems. Control infants without major birth defects were selected from vital records or birth hospital records. Self-reported maternal occupational histories were collected by telephone interview. Industrial hygienists reviewed this information to estimate exposure to aromatic, chlorinated and petroleum-based solvents from 1 month before conception through the first trimester of pregnancy. Cumulative exposure to solvents was estimated for the same period accounting for estimated exposure intensity and frequency, job duration and hours worked per week. ORs and 95% CIs were estimated to assess the association between exposure to any solvents or solvent classes, and gastroschisis risk.ResultsAmong 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively. Exposure to any solvent versus no exposure to solvents was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes. There was no exposure-response relationship between estimated cumulative solvent exposure and gastroschisis after adjusting for maternal age.ConclusionOur study found no association between maternal occupational solvent exposure and gastroschisis in offspring. Further research is needed to understand risk factors for gastroschisis.

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