scholarly journals Multiple Factors Involved in the Pathogenesis of White Matter Lesions

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Lin ◽  
Dilong Wang ◽  
Linfang Lan ◽  
Yuhua Fan
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Genetic Factors ◽  
Subsequent Development ◽  
White Matter Lesions ◽  
Blood Brain Barrier Disruption ◽  
Fluid Attenuated Inversion Recovery ◽  
Cerebral Blood Flow Autoregulation ◽  
Brain Barrier Disruption

White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.

P4-023: Cerebral blood flow, white matter lesions and cognitive performance. The Somatotrophics, Memory and Aging Research Trial (SMART)-MR Study

2008 ◽  
Vol 4 ◽  
pp. T674-T674
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Aging Research ◽  
Mr Study

High total cerebral blood flow is associated with a decrease of white matter lesions

2004 ◽  
Vol 251 (12) ◽  
pp. 1481-1485 ◽  
Author(s):  
R. H. C. Bisschops ◽  
Y. Graaf ◽  
W. P. Th. M. Mali ◽  
J. Grond
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions

scholarly journals IC-P1-025: Cerebral blood flow, white matter lesions and cognitive performance: The SMART-MR study

2008 ◽  
Vol 4 ◽  
pp. T18-T19
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Mr Study

Effects of global atrophy, white matter lesions, and cerebral blood flow on age-related changes in speed, memory, intelligence, vocabulary, and frontal function.

2007 ◽  
Vol 21 (6) ◽  
pp. 684-695 ◽  
Author(s):  
Patrick Rabbitt ◽  
Oemetse Mogapi ◽  
Marietta Scott ◽  
Neil Thacker ◽  
Christine Lowe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions ◽  
Age Related ◽  
Age Related Changes

White matter lesion burden in migraine with aura may be associated with reduced cerebral blood flow

Cephalalgia ◽  
2016 ◽  
Vol 37 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Quan Zhang ◽  
Ritobrato Datta ◽  
John A Detre ◽  
Brett Cucchiara
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
Migraine With Aura ◽  
Significant Difference ◽  
Fluid Attenuated Inversion Recovery ◽  
Weighted Magnetic Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
And Control

Objective The objective of this study was to determine whether white matter hyperintensities (WMHs) in subjects with migraine are related to alterations in resting cerebral blood flow (CBF). Methods Migraine with aura (MWA), migraine without aura (MwoA), and control subjects were enrolled in a 1:1:1 ratio. WMH load was scored based on fluid-attenuated inversion recovery/T2-weighted magnetic resonance imaging (MRI) using a previously established semi-quantitative scale. Global and regional CBFs were quantified using arterial spin labelled perfusion MRI. Integrity of the circle of Willis was assessed with magnetic resonance angiography (MRA). Results A total of 170 subjects were enrolled (54 controls, 56 MWA, and 60 MwoA). There was no significant difference in subjects with ≥1 WMH across groups (22% controls, 29% MWA, 35% MwoA; p = NS). Similarly, high WMH load was not significantly different across groups (16.7% controls, 21.4% MWA, 25.0% MwoA; p = NS). High WMH load was strongly associated with increasing age (odds ratio: 1.08 per year, 95% confidence interval: 1.02–1.13, p = 0.01). Resting CBF was similar across groups, but was significantly higher in women. In MWA subjects with high WMH load, CBF was substantially lower ( p = 0.03). No association between WMH load and CBF was seen in control or MwoA subjects. Conclusions WHMs in MWA may be related to alterations in resting CBF.

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