scholarly journals Bacillus cereus Typhlitis in a Patient with Acute Myelogenous Leukemia: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
James D. Denham ◽  
Sowmya Nanjappa ◽  
John N. Greene
Keyword(s):  
Bacillus Cereus ◽  
Acute Myelogenous Leukemia ◽  
English Language ◽  
Neutropenic Patient ◽  
Hematologic Malignancy ◽  
Case Reports ◽  
Clinical Manifestations ◽  
Case Series ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

Bacillus cereus is a Gram-positive rod that is now recognized as a rare cause of frank disease in the neutropenic hematologic malignancy patient. Because this pathogen is rarely isolated in clinical specimens, no large studies exist to guide the management of these acutely ill patients. Individual case reports and case series exist in the literature describing various clinical manifestations of B. cereus in the neutropenic patient including bacteremia/septicemia, pneumonia, meningitis/encephalitis, hepatic abscesses, and gastritis. In this report, we describe a case of typhlitis caused by B. cereus in a 74-year-old female with recently diagnosed acute myelogenous leukemia (AML), and we summarize the available English language literature to draw tentative conclusions regarding the clinical manifestations of this organism.

scholarly journals Successful treatment with low-dose decitabine in acute myelogenous leukemia in elderly patients over 80 years old: Five case reports

2013 ◽  
Vol 5 (4) ◽  
pp. 1321-1324 ◽  
Author(s):  
JIE LIN ◽  
HONGLI ZHU ◽  
SUXIA LI ◽  
HUI FAN ◽  
XUECHUN LU ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Successful Treatment ◽  
Acute Myelogenous Leukemia ◽  
Low Dose ◽  
Case Reports ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

Necrotizing Bacillus cereus infection of the meninges without inflammatory reaction in a patient with acute myelogenous leukemia: a case report

1997 ◽  
Vol 93 (3) ◽  
pp. 301-305 ◽  
Author(s):  
N. Motoi ◽  
Tsuyoshi Ishida ◽  
Imaharu Nakano ◽  
Nobu Akiyama ◽  
Kinuko Mitani ◽  
...  
Keyword(s):  
Case Report ◽  
Bacillus Cereus ◽  
Inflammatory Reaction ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

scholarly journals Paclitaxel Induced MDS and AML: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Udit Bhaskar Bhatnagar ◽  
Daulath Singh ◽  
Alexy Glazyrin ◽  
Jill Moormeier
Keyword(s):  
Literature Review ◽  
Acute Myelogenous Leukemia ◽  
Case Reports ◽  
Alkylating Agents ◽  
Treatment Options ◽  
Myelogenous Leukemia ◽  
Refractory Anemia ◽  
Myeloid Neoplasm ◽  
Acute Myelogenous ◽  
Acute Myelomonocytic Leukemia

Therapy related acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS) have been classically linked to alkylating agents and topoisomerase inhibitors. They constitute about 1% of all AMLs. There is less evidence on association of taxanes (paclitaxel and docetaxel) with these myeloid neoplasms. We present a case of paclitaxel therapy related acute myelogenous leukemia after treatment of endometrial cancer with a regimen containing paclitaxel and carboplatin. A 63-year-old female underwent surgery followed by a total of 6 cycles of chemotherapy with carboplatin and paclitaxel. Six months after last cycle of chemotherapy, she was diagnosed with myelodysplastic syndrome with refractory anemia and excess blasts. Six weeks later, she had worsening anemia and thrombocytopenia which prompted a bone marrow biopsy which revealed acute myelomonocytic leukemia. A thorough literature review revealed 12 other case reports where taxanes have been implicated in the development of therapy related myeloid neoplasm. Based on the timeline of events in our patient, paclitaxel is the likely culprit in the pathogenesis of this myeloid neoplasm. This rare but significantly grave adverse effect should be kept in consideration when deciding on treatment options for gynecological malignancies.

scholarly journals Decitabine Induced Delayed Cardiomyopathy in Hematologic Malignancy

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Pradyumna Agasthi ◽  
Hemalatha Narayanasamy ◽  
Dan Sorajja ◽  
James Slack ◽  
Farouk Mookadam
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Chronic Myelogenous Leukemia ◽  
Myelodysplastic Syndromes ◽  
Acute Myelogenous Leukemia ◽  
Hematologic Malignancy ◽  
Myelogenous Leukemia ◽  
Pyrimidine Analogue ◽  
Acute Myelogenous

Decitabine is a pyrimidine analogue of nucleoside cytidine, used for the treatment of myelodysplastic syndromes, chronic myelogenous leukemia, and acute myelogenous leukemia. We present a case of cardiomyopathy associated with decitabine used for secondary acute myelogenous leukemia. The patient presented with new heart failure symptoms and an ejection fraction decline.

scholarly journals A case of acute myelogenous leukemia, complicated with Bacillus cereus septicemia

1977 ◽  
Vol 51 (8) ◽  
pp. 438-442 ◽  
Author(s):  
Eiichi TERASHIMA ◽  
Toshio TSUCHIYA ◽  
Kiyoko OKUYAMA ◽  
Akira HORIKOSHI ◽  
Koichi TAKAHASHI ◽  
...  
Keyword(s):  
Bacillus Cereus ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

Fatal Bacillus cereus Meningoencephalitis in an Adult With Acute Myelogenous Leukemia

1995 ◽  
Vol 88 (9) ◽  
pp. 969-972 ◽  
Author(s):  
EDITH F. MARLEY ◽  
NIRMAL K. SAINI ◽  
CHITRA VENKATRAMAN ◽  
JAN M. ORENSTEIN
Keyword(s):  
Bacillus Cereus ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

scholarly journals 189. A Case Series of Elizabethkingia meningosepticum Bacteremia in the Cancer Population

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S114-S115
Author(s):  
Dae Hyun Lee ◽  
Ishita Mehra ◽  
Sanjay Chandrasekhar ◽  
Abu-Sayeef Mirza ◽  
Rahul Shenoy ◽  
...  
Keyword(s):  
Blood Culture ◽  
Acute Myelogenous Leukemia ◽  
Case Series ◽  
Neutropenic Fever ◽  
Myelogenous Leukemia ◽  
Patient History ◽  
Chest Port ◽  
Stable Conditions ◽  
Acute Myelogenous ◽  
History Of

Abstract Background Elizabethkingia meningosepticum (E. meningosepticum) is a ubiquitous microorganism previously known as Chryseobacterium meningosepticum. It is emerging as a pathogen responsible for bacteremia in immunocompromised patients such as cancer patients especially those with a history of prolonged hospital stay and frequent instrumentations. Methods A retrospective chart review of all cases over 10 years in Moffitt Cancer Center showed a total of three patients with E. meningosepticum infection. Results First patient (history of multiple myeloma) underwent endoscopy complicated by aspiration pneumonia and blood culture positive for E. meningosepticum infection. He was treated with ciprofloxacin, cefoxitin, minocycline and metronidazole and was discharged in stable conditions after 10 days. The second patient (current acute myelogenous leukemia) had neutropenic fever in the setting of recent chest port infection. Blood culture from chest port showed E. meningosepticum and was treated with ciprofloxacin, meropenem and minocycline successfully. The third patient (history of esophageal adenocarcinoma and acute myelogenous leukemia) had history of recent pneumonia and cellulitis who came in with recurrent neutropenic fever. Blood culture was positive for E. meningosepticum and was treated with ciprofloxacin and minocycline. However, the infection was complicated by multiorgan failure and required tracheostomy. As these three cases illustrate, E. meningosepticum bacteremia has high 28- day mortality rate (41%). Conclusion Early identification of the pathogen along with empiric treatment with a fluoroquinolone and/or minocycline is indicated to reduce morbidity and mortality. Disclosures All authors: No reported disclosures.

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