scholarly journals Primary Peritoneal Cancer Two Decades after a Bilateral Salpingo-Oophorectomy

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Melinda Rodowa ◽  
Amir H. Salehi ◽  
Jacob McGee
Keyword(s):  
Pelvic Mass ◽  
Serous Carcinoma ◽  
Abdominal Girth ◽  
Primary Peritoneal Cancer ◽  
Peritoneal Cancer ◽  
Occult Malignancy ◽  
Pathologic Assessment ◽  
History Of ◽  
Papillary Serous Carcinoma ◽  
Risk Reducing

Bilateral salpingo-oophorectomy (BSO) is increasingly employed as a risk-reducing strategy for epithelial ovarian cancer (EOC). We report the third case of a patient developing primary peritoneal cancer two decades after a bilateral salpingo-oophorectomy. This 66-year-old female underwent a hysterectomy for pelvic pain at age 28 and a subsequent bilateral salpingo-oophorectomy (BSO) at age of 45 for a pelvic mass. Presenting with a 6-month history of increasing abdominal girth, decreased energy, and a reduction in appetite, she was consented for a unilateral salpingo-oophorectomy, omentectomy, and cytoreductive surgery. Pathology specimens revealed a high grade metastatic papillary serous carcinoma consistent with a primary gynecologic origin. It is unlikely that an occult malignancy was missed at the time of pathologic assessment following her previous BSO; therefore it provides evidence that primary peritoneal cancers can arise through the malignant transformation of benign endosalpingiosis.

Impact of tubal ligation on the natural history of uterine papillary serous carcinoma

2012 ◽  
Vol 127 (1) ◽  
pp. S6
Author(s):  
T. Ayeni ◽  
M. Al Hilli ◽  
A. Mariani ◽  
J. Bakkum-Gamez ◽  
S. Dowdy ◽  
...  
Keyword(s):  
Natural History ◽  
Tubal Ligation ◽  
Serous Carcinoma ◽  
Uterine Papillary Serous Carcinoma ◽  
History Of ◽  
Papillary Serous Carcinoma

Primary Peritoneal Serous Borderline Tumors

2007 ◽  
Vol 131 (1) ◽  
pp. 138-144 ◽  
Author(s):  
C. P. T. Robert L. Hutton, MC ◽  
M. A. J. Scott R. Dalton, MC
Keyword(s):  
Clinical Presentation ◽  
Incidental Finding ◽  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Epithelial Proliferation ◽  
National Library ◽  
Psammoma Bodies ◽  
Serous Borderline Tumor ◽  
History Of ◽  
Papillary Serous Carcinoma

Abstract Context.—Primary peritoneal serous borderline tumor is a rare epithelial proliferation that can present as an incidental finding at laparotomy and raises concern for a primary ovarian tumor with peritoneal implants. Objective.—To present a brief history of this condition and describe its distinctive histology and clinical presentation, as well as to review the chief differential diagnostic considerations, to include mesothelial proliferations, endosalpingiosis, endometriosis, high-grade primary peritoneal papillary serous carcinoma, and implants from primary ovarian serous neoplasms. Data Sources.—Relevant articles indexed in PubMed (National Library of Medicine) between 1966 and 2005, references thereof, and reference surgical pathology texts. Conclusions.—Primary peritoneal serous borderline tumor should be considered in the differential diagnosis of an epithelial proliferation with prominent psammoma bodies on the peritoneal surface of specimens submitted for nongynecologic complaints.

scholarly journals Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

Folia Medica ◽  
2020 ◽  
Vol 62 (1) ◽  
pp. 195-199
Author(s):  
Nikolaos Blontzos ◽  
Christos Iavazzo ◽  
Eirini Giovannopoulou ◽  
George Galanopoulos ◽  
Victoria Psomiadou ◽  
...  
Keyword(s):  
Pap Smear ◽  
Ovarian Tissue ◽  
Serous Carcinoma ◽  
Cervical Smear ◽  
Peritoneal Cancer ◽  
Endometrial Tumor ◽  
Abdominal Mri ◽  
Surgical History ◽  
History Of ◽  
Rare Malignancy

Primary peritoneal serous carcinoma (PPSC) is a rare malignancy, the clinical characteristics of which resemble ovarian serous carcinoma. We present a rare case of PPSC detected by an abnormal cervical smear, the first one with an absence of ovarian tissue at the time of the initial diagnosis. A 59-year-old asymptomatic woman presented with glandular atypia on routine Papanicolaou smear. Endocervical and endometrial curettage showed an adenocarcinoma with focal squamous differentiation and uncertain further classification. The patient had a past surgical history of bilateral salpingoophorectomy due to endometriosis. Abdominal MRI depicted omental multinodularity, great amount of ascites and possible endometrial tumor. The patient underwent total hysterectomy, omentectomy and biopsies of implants on Douglass pouch.  Surgical and histological findings were consistent with primary peritoneal serous carcinoma.  Abnormal pap smear could rarely be suggestive of extrauterine malignancies, such as peritoneal cancer.

Short- and long-term outcomes for single-port risk-reducing salpingo-oophorectomy with and without hysterectomy for women at risk for gynecologic cancer

2020 ◽  
pp. ijgc-2020-001405
Author(s):  
Caitlin E Carr ◽  
Laura Chambers ◽  
Amelia Marie Jernigan ◽  
Lindsey Freeman ◽  
Pedro F Escobar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Port ◽  
Task Force ◽  
Absolute Risk ◽  
Gynecologic Cancer ◽  
Adverse Outcomes ◽  
Personal History ◽  
Peritoneal Cancer ◽  
History Of ◽  
Risk Reducing

IntroductionRisk-reducing salpingo-oophorectomy has been established as one of the most effective strategies in risk reduction for ovarian and breast cancers among women at increased genetic risk. However, there are limited data regarding the single-port laparoscopic platform in the field of risk-reducing surgery. Our objective was to describe outcomes after single-port risk-reducing salpingo-oophorectomy with or without hysterectomy for reduction of ovarian, breast, or endometrial cancer risk.MethodsA retrospective, single institution (Canadian Task Force Classification II.2) analysis was performed in women at high genetic or familial risk for ovarian/tubal/primary peritoneal cancer or with personal history of breast cancer who underwent single-port laparoscopic risk-reducing salpingo-oophorectomy with or without hysterectomy between October 2009 and December 2015. Data were collected on patient demographics, surgical procedure and characteristics, intra-operative findings, and post-operative outcomes.ResultsIn total, 187 single-port laparoscopic surgeries were performed with a median follow-up of 204 (IQR 25–749) days. BRCA1/2, Lynch syndrome, or Cowden syndrome was diagnosed in 64.0% of patients. Additionally, 32.1% had a personal history of breast cancer, and 3.2% reported strong family history of ovarian and/or breast cancer. Single-port risk-reducing salpingo-oophorectomy with hysterectomy was performed in 53.5% of patients. The rate of adverse outcomes, including conversion to multiport laparoscopy or laparotomy (1.6%), intra-operative injury (1.6%), deep vein thrombosis (0.5%), urinary tract infection (2.7%), and/or incisional cellulitis (4.3%) were low. Three patients (1.6%) were diagnosed with malignancy on final pathology. All three patients were BRCA1-positive and their CA125 values were significantly lower than those without malignancy (p=<0.0001).ConclusionsSingle-port laparoscopy is a safe option for patients undergoing risk-reducing salpingo-oophorectomy with or without hysterectomy. Standardized pre-operative evaluation criteria are needed to determine absolute risk of incidental malignancy, and the risk of identifying a malignancy should be reiterated to patients during pre-operative counseling.

Family History of Cancer Shows Improved Survival in Uterine Papillary Serous Carcinoma

2017 ◽  
Vol 147 (1) ◽  
pp. 225-226
Author(s):  
L.H. Palavalli Parsons ◽  
K.Y. Lin ◽  
D.S. Miller ◽  
D. Richardson ◽  
M. Carlson ◽  
...  
Keyword(s):  
Family History ◽  
Serous Carcinoma ◽  
Family History Of Cancer ◽  
Uterine Papillary Serous Carcinoma ◽  
History Of ◽  
Papillary Serous Carcinoma ◽  
History Of Cancer

Peritoneal Papillary Serous Carcinoma in a Woman with a History of in Utero DES Exposure

1993 ◽  
Vol 50 (3) ◽  
pp. 371-373 ◽  
Author(s):  
Muhieddine A-F. Seoud ◽  
Ossama Tawfik ◽  
Verda Hunter
Keyword(s):  
In Utero ◽  
Serous Carcinoma ◽  
History Of ◽  
Papillary Serous Carcinoma

scholarly journals Uptake Rate of Risk-reducing Salpingo-oophorectomy and Surgical Outcomes of Female Germline BRCA1/2 Mutation Carriers: A Retrospective Cohort Study at a Tertiary Institutional Hospital in Korea

2021 ◽  
Author(s):  
Hyunji Lim ◽  
Se Ik Kim ◽  
Sowoon Hyun ◽  
Gwang Bin Lee ◽  
Aeran Seol ◽  
...  
Keyword(s):  
Uptake Rate ◽  
Surgical Outcomes ◽  
Genetic Test ◽  
Preoperative Evaluation ◽  
University Hospital ◽  
Serous Carcinoma ◽  
Time Interval ◽  
Peritoneal Cancer ◽  
Mutation Carriers ◽  
Risk Reducing

Abstract Background: This study investigated the uptake rate of risk-reducing salpingo-oophorectomy (RRSO) and surgical outcomes of germline BRCA1/2 mutation carriers at Seoul National University Hospital (SNUH). We examined records of 824 women who underwent germline BRCA1/2 gene testing at SNUH between 2005 and 2020. Among them, we identified women with a pathogenic mutation on either the BRCA1 or the BRCA2 gene and excluded ovarian cancer patients. Characteristics of participants who underwent RRSO (RRSO group) were compared to those who did not (non-RRSO group). Surgical outcomes and pathologic results were investigated in the RRSO group.Results: There were 117 BRCA1/2 mutation carriers included in this analysis. The uptake rate of RRSO was 70.1% (82/117). Older age (mean: 48.8 vs. 42.1 years; P = 0.002) and higher employment rate (65.9% vs. 14.3%; P < 0.001) were observed in the RRSO group than in the non-RRSO group. However, no differences in other factors such as personal and family history of breast cancer were observed between the two groups. In the RRSO group, the median time interval between the genetic test and RRSO was 10.0 months, and there were three (3.7%) incidental cases of high-grade serous carcinoma. However, one patient in the non-RRSO group developed primary peritoneal cancer after 103.8 months of surveillance.Conclusions: The uptake rate of RRSO in BRCA1/2 mutation carriers was about 70%. Considering incidental cancer cases in women without abnormal findings on preoperative evaluation, it would be recommended to perform RRSO soon after the genetic test.

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