scholarly journals Babassu (Attalea glassmanii Zona) Nut Oil Is More Effective than Olive Oil for Treating Ischemia-Reperfusion Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Fábio França Silva ◽  
Daniela Signorelli Balthazar ◽  
Thauany Hellmann ◽  
Joaquim Silva Sales ◽  
Gyl Eanes Barros Silva ◽  
...  
Keyword(s):  
Protective Effect ◽  
Olive Oil ◽  
Chemical Compound ◽  
Dose Group ◽  
Ischemia Reperfusion ◽  
Virgin Olive Oil ◽  
Dose Effect ◽  
Cheek Pouch ◽  
Babassu Oil ◽  
Compound C

Background. Cardiovascular disease (CVD) is the leading cause of death in Western civilizations. The type of fatty acid which makes up the diet is related to the cardiovascular morbimortality and the formation of atheromas. Populations with high consumption of oils and fats have a higher number of deaths from CVD. Purpose. In the present study, the objective was to comparatively analyze the microcirculatory effects of unrefined babassu oil with olive oil in microcirculation and liver of male hamsters of the species Mesocricetus auratus, checking the permeability to macromolecules after ischemia-reperfusion (I/R) without and with topical application of histamine 5 × 10−6 M. This is an experimental study, using as model the hamster’s cheek pouch, which was prepared for intravital microscopy. The hamsters were divided into seven groups and orally treated for 14 days, twice a day (at 8 AM and 4 PM), orally received treatments in the following doses: unrefined babassu oil (BO) 0.02 mL/dose (group BO-2), 0.06 mL/dose (group BO-6), and 0.18 mL/dose (BO-18 group); extra virgin olive oil (OI) 0.02 mL/dose (group OI-2), 0.06 mL/dose (group OI-6), and 0.18 mL/dose (OI-18 group); and mineral oil (MO) 0.18 mL/dose (MO-18 group). The observations were made on the 15th day on the hamsters’ cheek pouch; the increase of vascular permeability induced by I/R with and without histamine application was evaluated, and in the liver the biological material was collected aseptically then fixed in 10% buffered formalin. Results. Microcirculatory analyses showed a significant reduction in the number of leaks after I/R with and without the topical use of histamine in animals treated with unrefined BO 0.06 mL/dose (BO-6) and 0.18 mL/dose (BO-18) compared to animals treated with OI. The BO group (p<0.001) presented a dose-response relationship for decreasing leaks after I/R with and without topical use of histamine. Histological liver analyses showed no fat deposition changes in any of the treatment groups. Phytochemical analyses evidenced a chemical compound (C31H60NO8) in unrefined BO but not in OI. Conclusions. This experiment demonstrates the protective effect of unrefined BO on the microcirculatory system and its greater dose effect than that of OI. Finding a chemical compound (C31H60NO8) that is present in BO but not in OI opens the possibility of investigating whether this chemical compound was responsible for the protective effect on membrane permeability.

Alternariol-induced cytotoxicity in Caco-2 cells. Protective effect of the phenolic fraction from virgin olive oil

Toxicon ◽  
2015 ◽  
Vol 93 ◽  
pp. 103-111 ◽  
Author(s):  
C. Chiesi ◽  
C. Fernandez-Blanco ◽  
L. Cossignani ◽  
G. Font ◽  
M.J. Ruiz
Keyword(s):  
Protective Effect ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Phenolic Fraction

Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis

2020 ◽  
Vol 11 (10) ◽  
pp. 8670-8679
Author(s):  
Sara Fernandes ◽  
Catarina Ribeiro ◽  
Fátima Paiva-Martins ◽  
Cristina Catarino ◽  
Alice Santos-Silva
Keyword(s):  
Cardiovascular Diseases ◽  
Protective Effect ◽  
Olive Oil ◽  
Phase Ii ◽  
Lower Incidence ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Polyphenol Content

The consumption of extra virgin olive oil (EVOO) has been associated with a lower incidence of cardiovascular diseases partly due to its polyphenol content.

scholarly journals Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion

2017 ◽  
pp. ajcn145813 ◽  
Author(s):  
Rafael De la Torre ◽  
Dolores Corella ◽  
Olga Castañer ◽  
Miguel A Martínez-González ◽  
Jordi Salas-Salvador ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Protective Effect ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Total Mortality

Protective Effect on Oxidative Stress Injury of Xiongma Dripping Pills Containing Serum on PC12 Cells

2014 ◽  
Vol 955-959 ◽  
pp. 744-747
Author(s):  
Lin Liu ◽  
Jia Yi Xia ◽  
Ju Huo ◽  
Zhao Ying
Keyword(s):  
Oxidative Stress ◽  
Plasma Concentration ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc12 Cells ◽  
Dose Group ◽  
Dose Effect ◽  
Cell Culture Supernatant ◽  
Stress Injury ◽  
Oxidative Stress Injury

Object: The antioxidant dose-effect relationship and the mechanism of Xiongma Dripping Pills were study to explore the protective effects of oxidative damage in PC12 cells of different doses of Xiongma Dripping Pills containing serum. Method: Oxidative stress injury model of PC12 cells was established by peroxide hydrogen (H2O2), sodium nitroprusside (SNP), content and cell culture supernatant lactate dehydrogenase (LDH) and the liquid content of glutathione peroxidase (GSH-PX) were detected by chemical colorimetric determination. Results: There was a plasma concentration peaked in Xiongma Dripping Pills 8 times (6g•kg-1) dose group, ferulic acid plasma concentration was 10.59 ± 2.92, the plasma concentration gastrodin 18.13 ± 4.63. H2O2 and SNP could cause injury in PC12 cells, and increased LDH leakage, reduce the content of GSH-PX (P<0.01). Gung Ma the Dripping Pills can reduce LDH leakage, increase the content of GSH-PX. Xiongma Dripping Pills 8-fold dose group content is the most significant.Conclusion: There was a significant protective effect on Xiongma Dripping Pills serum containing H2O2 and SNP induced oxidative damage of PC12 cells and its mechanism was relevant with clearing the free radicals, enhanceing antioxidant enzyme activity in vivo. There was the most significant effect on Xiongma Dripping Pills 8-fold dose group, and there was positive correlation on plasma concentration and pharmacological effects.

The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat

2018 ◽  
Vol 23 (1) ◽  
pp. 37-48 ◽  
Author(s):  
C. Conde ◽  
B.M. Escribano ◽  
E. Luque ◽  
M. Aguilar-Luque ◽  
M. Feijóo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Protective Effect ◽  
Olive Oil ◽  
Experimental Model ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil

scholarly journals Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1722 ◽  
Author(s):  
Melguizo-Rodríguez ◽  
Manzano-Moreno ◽  
Illescas-Montes ◽  
Ramos-Torrecillas ◽  
Luna-Bertos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alkaline Phosphatase ◽  
Phenolic Compounds ◽  
Protective Effect ◽  
Olive Oil ◽  
Transforming Growth Factor ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Bone Morphogenetic Protein 2 ◽  
Type I

The phenolic compounds of extra-virgin olive oil can act at various levels to protect individuals against cardiovascular and neurodegenerative diseases, cancer, and osteoporosis, among others. Polyphenols in extra-virgin olive oil can stimulate the proliferation of osteoblasts, modify their antigen profile, and promote alkaline phosphatase synthesis. The objective of this work was to determine the effect of different extra-virgin olive oil phenolic compounds on the gene expression of osteoblast-related markers. The cells of the MG63 osteoblast line were cultured for 24 h with 10-6 M of the phenolic compounds ferulic acid, caffeic acid, coumaric acid, apigenin, or luteolin. The expression of studied markers was quantified using quantitative real-time polymerase chain reaction (q-RT-PCR). The expression by MG63 osteoblasts of growth and differentiation/maturation markers was modified after 24 h of treatment with 10-6 M of the phenolic compounds under study, most of which increased the gene expression of the transforming growth factor β1 (TGF-β1), TGF-β receptor 1,2 and 3 (TGF-βR1, TGF-βR2, TGF-βR3), bone morphogenetic protein 2 and 7 (BMP2, BMP7), run-related transcription factor 2 (RUNX-2), Alkaline phosphatase (ALP), Osteocalcin (OSC), Osterix (OSX), Collagen type I (Col-I) and osteoprotegerin (OPN). The extra-virgin olive oil phenolic compounds may have a beneficial effect on bone by modulating osteoblast physiology, which would support their protective effect against bone pathologies.

A preliminary study on the potential of front face fluorescence spectroscopy for the discrimination of Moroccan virgin olive oils and the prediction of their quality

2021 ◽  
Author(s):  
Hicham Zaroual ◽  
El Mestafa El Hadrami ◽  
Romdhane Karoui
Keyword(s):  
Fluorescence Spectroscopy ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Front Face ◽  
Virgin Olive Oils ◽  
Olive Oils ◽  
Preliminary Study

This study examines the feasibility of using front face fluorescence spectroscopy (FFFS) to authenticate 41 virgin olive oil (VOO) samples collected from 5 regions in Morocco during 2 consecutive crop seasons.

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