scholarly journals Effect of Peat Intervention on Pain and Gait in Patients with Knee Osteoarthritis: A Prospective, Double-Blind, Randomized, Controlled Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Myeongkyu Kim ◽  
Kyu Hoon Lee ◽  
Seung Hoon Han ◽  
Sung Jae Lee ◽  
Choong-Gon Kim ◽  
...  
Keyword(s):  
Pain Relief ◽  
Knee Osteoarthritis ◽  
Range Of Motion ◽  
Matrix Protein ◽  
Intervention Group ◽  
Gait Velocity ◽  
Controlled Study ◽  
Control Group ◽  
Significant Difference ◽  
Hot Pack

Background/Purpose. Peat is a plant material that is decayed in anaerobic and acidic conditions. Peat is known for its pain relief effect on degenerative and rheumatologic diseases for hundreds of years. This research aims to see effects of peat intervention on knee osteoarthritis patients’ pain, biomarkers, and parameters about gait. Methods. Knee osteoarthritis patients with Visual Analog Scale (VAS) of 3 or more and Kellgren–Lawrence osteoarthritis grades 1 to 3 were included. Patients with history of intraarticular injection treatment were excluded. Forty-one participants were randomly allocated to the peat intervention group (n = 22) or the hot-pack-only control group (n = 19). Peat and hot pack were applied to both knees of each group of patients. Each intervention session lasted 20 minutes, and eight sessions were completed over five days. VAS, serum cartilage oligomeric matrix protein (COMP), and gait parameters were evaluated before and after the whole interventions. Results. VAS in the peat group decreased from 6.000 to 3.409 after intervention (p<0.001) and also decreased in the control group from 5.737 to 4.421 (p<0.001). VAS score reduction between two periods was greater in the peat group than that in the control group (p<0.001). There was no significant difference in the serum COMP level in either intergroup or intragroup analysis. In gait analysis, the gait velocity of the peat group increased from 0.781 m/s to 0.873 m/s after intervention (p=0.002), while it decreased in the control group. The knee varus/valgus range of motion during gaits was reduced from 11.455° to 8.439° after intervention in the peat group (p=0.006). Conclusions. This study showed that peat can be considered as a therapeutic option for pain relief of knee osteoarthritis patients. The reduction in knee joint varus/valgus range of motion and the increase in gait velocity after peat intervention were also identified through this research, which is the first to analyze the effects of peat on gait.

The effect of interactive computer play on balance and functional abilities in children with moderate cerebral palsy: a pilot randomized study

2019 ◽  
Vol 33 (4) ◽  
pp. 704-710 ◽  
Author(s):  
Tamis W Pin ◽  
Penelope B Butler
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Intervention Group ◽  
Controlled Study ◽  
Control Group ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Gross Motor Function Measure ◽  
Significant Difference ◽  
Function Measure

Objectives: To investigate the feasibility and potential efficacy of a six-week interactive computer play training on balance and gross motor function in children with moderate cerebral palsy. Design: A pilot single-blinded matched randomized controlled study. Setting: Community. Participants: In total, 18 children with moderate cerebral palsy were recruited, paired according to age and severity of cerebral palsy and randomized into intervention group or control group. Intervention: The intervention group received additional trunk control training using the interactive computer play in sitting four times per week, 20 minutes per session for six weeks. All study children continued their usual physiotherapy programme. Measurements: All study children were assessed at baseline, week 3, week 6 (completion of intervention) and week 12 using the Pediatric Reach Test, Gross Motor Function Measure–66-Item Set and 2-Minute Walk Test. Results: All intervention children completed and enjoyed the training with no reported adverse event. All children were assessed at all time points. No significant difference was found between the two groups in all assessments. In both groups of children, significant improvements were found in the Gross Motor Function Measure–66-Item Set between week 3 (intervention group: mean 53.41, SD 5.34; control group: mean 52.86, SD 8.33) and week 6 (intervention group: mean 55.00, SD 6.32; control group: mean 54.20, SD 8.35). Conclusion: The intervention protocol of a six-week interactive computer play training was feasible and safe for children with moderate cerebral palsy in special school settings. Future studies with larger sample sizes or using single-subject designs are recommended.

scholarly journals Music intervention affects the quality of life on Alzheimer’s disease: a meta-analysis

2021 ◽  
Author(s):  
Lingyan Zuo ◽  
Fengting Zhu ◽  
Rui Wang ◽  
Hongyan Shuai ◽  
Xin Yu
Keyword(s):  
Meta Analysis ◽  
Intervention Group ◽  
Original Data ◽  
Controlled Study ◽  
Control Group ◽  
Music Intervention ◽  
Significant Difference ◽  
Review Question ◽  
Intervention Modality ◽  
The Impact

Review question / Objective: Inclusion criteria: population: 1) A randomized controlled study on the impact of music intervention on the QOL of patients with AD; 2) The participants in this study is patients with AD; 3) There is no significant difference among age, gender and education background in sorted groups before analysis which make these groups comparable; intervention: 1)Intervention Modality Music-based intervention; comparison: 1) All data were sorted into two groups: the music intervention group and the control group without any music intervention; outcome: 1) The indicators evaluated in the literature included the score of QOL-AD or WHOQOL-BERF scale, at least one of the two scales summarized in selected publications; language: 1) Only articles published in English and Chinese were considered. Exclusion criteria: 1) The participants were not diagnosed with AD; 2) Non-musical intervention;3) Non-RCTs; 4) No specific values for outcome variables; 5) Articles lacking original data; 6) Repeat published reports; 7) Full text could not be obtained.

scholarly journals A randomised controlled trial to evaluate a medication monitoring system for TB treatment

2022 ◽  
Vol 26 (1) ◽  
pp. 44-49
Author(s):  
J. Acosta ◽  
P. Flores ◽  
M. Alarcón ◽  
M. Grande-Ortiz ◽  
L. Moreno-Exebio ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Treatment Success ◽  
Intervention Group ◽  
Controlled Study ◽  
Control Group ◽  
Second Phase ◽  
Open Label ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Significant Difference

BACKGROUND: Adherence to TB treatment and therefore treatment success could be improved using digital adherence technology.OBJECTIVE: To evaluate the effectiveness of a medication event reminder monitor system (MERM) on treatment success and treatment adherence in patients with drug-susceptible pulmonary TB in Perú.METHODS: This was an experimental, randomised, open-label, controlled study conducted among patients in the second phase of TB treatment. The intervention group received their medications through MERM with the support of a treatment monitor, whereas the control group used the usual strategy. Participants were followed until they completed the 54 doses of the second phase of treatment.RESULTS: The study included 53 patients in each group; four in the intervention group withdrew from the study. Treatment success was significantly more frequent in the MERM group (RR 1.15, 95% CI 1.02–1.30; P = 0.0322). There was no significant difference in the adherence outcomes; however, the percentage of patients who missed at least one dose and patients with more than 10% of total doses missed were lower in the intervention group.CONCLUSION: The use of MERM in the second phase of treatment showed a significant improvement in the treatment success rate in patients with drug-susceptible pulmonary TB.

scholarly journals L-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis women

2017 ◽  
Vol 12 (1) ◽  
pp. 28 ◽  
Author(s):  
Reza Mahdavi ◽  
Sousan Kolahi ◽  
Vahideh Ebrahimzadeh Attari ◽  
Aida Malek Mahdavi
Keyword(s):  
Placebo Group ◽  
Knee Osteoarthritis ◽  
Global Assessment ◽  
Intervention Group ◽  
Controlled Study ◽  
Carnitine Supplementation ◽  
Double Blind ◽  
Necrosis Factor Alpha ◽  
Matrix Metalloproteinase 3 ◽  
Significant Difference

<p class="Abstract">Seventy-two females with mild to moderate knee osteoarthritis were included in this randomized double-blind placebo-controlled study. Patients in the intervention group (n=36) received L-carnitine supplement (750 mg/day) for two months. L-Carnitine supplementation led to decrease in serum TNF-α and MMP-3 levels significantly in comparison with the baseline (p&lt;0.001 and p&lt;0.001, respectively) and placebo group (p&lt;0.001 and p=0.03, respectively). In addition, physician’s global assessment of the severity of osteoarthritis decreased significantly in the L-carnitine group (p&lt;0.001) and placebo group (p=0.012) after supplementation. At the end of the study, a significant difference was observed between the two groups for mean physician’s global assessment of the severity of osteoarthritis (p&lt;0.001), adjusted for baseline values and duration of osteoarthritis. L-Carnitine supplementation has beneficial effects in reducing inflammatory biomarkers in knee osteoarthritis patients which subsequently leads to the alleviation of disease symptoms.</p>

scholarly journals Effectiveness of Combination Myofascial Release and Kinesio Taping Intervention on Range of Motion Improvement in Elderly with Knee Osteoarthritis

2020 ◽  
Vol 1 (1) ◽  
pp. 13-16
Author(s):  
Afif Zainuri Wafiq ◽  
Atika Yulianti
Keyword(s):  
Knee Osteoarthritis ◽  
Range Of Motion ◽  
Cartilage Damage ◽  
The Elderly ◽  
Rank Test ◽  
Control Group ◽  
Case Group ◽  
Myofascial Release ◽  
Kinesio Taping ◽  
Significant Difference

Introduction: Knee Osteoarthritis is a condition that frequently occurs in elderly which has a major impact on the elderly’s disability. As a degenerative disease, knee osteoarthritis occurs due to cartilage damage which is then accompanied by inflammation, pain, stiff joints and muscles thereby limiting the range of motion. This research aims to compare the effect of Kinesio taping and a combination of myofascial release and Kinesio taping intervention on ROM improvement in elderly with knee osteoarthritis.Methods: This study applies a quasi-experimental design with a non-equivalent group approach. Goniometer is applied as a measurement instrument. 25 people participated in this study who were recruited through purposive sampling. The sample was then divided into 2 groups which were given treatment 3 times a week in one month. The control group with Kinesio Taping treatment consisted of 14 samples and the case group with a combination treatment of myofacial release and Kinesio taping consisted of 11 samples. Furthermore, data analysis was performed with the Shapiro Wilk test, Wilcoxon rank test, and the Mann-Whitney test using SPSS version 25.Results: The comparison test results show that the significance value of p yields 0.6> 0.05, therefore H1 is rejected, and H0 is accepted. The interpretation of these results is that there is no significant difference between the effects of Kinesio taping and the combination of myofacial release and Kinesio taping on increasing ROM in the elderly with the risk of knee osteoarthritis.Conclusion: This study shows that there is no significant difference in the effect of the treatment of Kinesio taping and the combination of myofacial release and Kinesio taping in increasing ROM in the elderly with osteoarthritis.

scholarly journals The Effectiveness of Tuberculosis Education Programme in Kelantan, Malaysia on Knowledge, Attitude, Practice and Stigma Towards Tuberculosis among Adolescents

2020 ◽  
Vol 27 (6) ◽  
pp. 102-114
Author(s):  
Nur Aiza Idris ◽  
Rosnani Zakaria ◽  
Rosediani Muhamad ◽  
Nik Rosmawati Nik Husain ◽  
Azlina Ishak ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Smoking Status ◽  
Intervention Group ◽  
Education Programme ◽  
Transmission Risk ◽  
Controlled Study ◽  
Control Group ◽  
School Students ◽  
Stigma Score ◽  
Significant Difference

Background: Tuberculosis (TB) is contagious and the transmission risk is high in congregate settings like school. Incidence of TB among adolescents is significantly high hence an education programme was developed to improve knowledge, attitude, practice and stigma (KAPS) among them. Methods: This school-based, non-randomised controlled study was conducted among secondary school students with a total of 236 respondents. The KAPS score were assessed before and 1 month after using self-administered validated KAPS questionnaire on TB. Analysis was done using repeated measures ANOVA. Results: The mean percentage score (SD) for baseline knowledge, attitude, practice and stigma score for the respondents were 54.0 (4.48), 65.6 (1.74), 70.0 (1.43) and 66.0 (6.88), respectively. There was a significant difference (P < 0.001) in the knowledge and stigma score for intervention group compared to control group, adjusted for gender, ethnicity and smoking status 4 weeks post-TB educational programme. However, with regards to attitude and practice score, there was no significant difference (P = 0.210 and P = 0.243, respectively). Conclusion: TB education programme was effective in improving knowledge and stigma related to TB. This health education programme can be used as one of the strategies for the prevention and control of TB in schools.

scholarly journals The Effects of Transcutaneous Electrical Nerve Stimulation on Post-Episiotomy Pain Severity in Primiparous Women: A Randomized, Controlled, Placebo Clinical Trial

2019 ◽  
Vol 8 ◽  
pp. 1404
Author(s):  
Seyedeh Soma Zakariaee ◽  
Roonak Shahoei ◽  
Leila Hashemi Nosab ◽  
Ghobad Moradi ◽  
Mina Farshbaf
Keyword(s):  
Clinical Trial ◽  
Pain Relief ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Intervention Group ◽  
Pain Severity ◽  
Control Group ◽  
Electrical Nerve Stimulation ◽  
Significant Difference ◽  
The Mean ◽  
Primiparous Women

Background: Episiotomy or cutting the perineum is the most common operation in obstetrics. Perineal pain is the main complication of episiotomy that affects the quality of life and mental health of the mother. Reducing the pain and side effects of the chemical drugs prescribed for pain relief has attracted the attention of both physicians and scientists. This study was conducted to determine the effects of transcutaneous electrical nerve stimulation (TENS), as an alternative method, on post-episiotomy pain severity. Materials and Methods: This randomized clinical trial was performed on 120 primiparous women who had referred to Sanandaj Besat Hospital in 2018. The patients were divided randomly into three groups, including the intervention group (TENS-On), the placebo group (TENS-Off), and the control group. TENS electrodes were placed near the episiotomy site in genitofemoral and pudendal nerves. The pain was measured after episiotomy in lying, sitting, and activity positions. The pain severity was measured using a pain measurement instrument (numeral rating score) at four-time points, i.e., before the intervention as well as 30, 60, and 120 minutes after the TENS intervention. For data analysis, Pearson correlation, student’s t-test, Kruskal-Wallis test, ANOVA test, and Mann-Whitney U tests were used. Results: Intragroup evaluation results for placebo and control groups demonstrated no significant difference in the pain score (P>0.05). A significant difference was observed between the mean pain severity of the intervention group and that of the group with walking activities (P=0.04). In terms of the intergroup evaluation, there was a significant difference observed between the mean pain severity of the lying position and that of the control group (P=0.008). Regarding the sitting position, no significant difference was observed between its mean pain severity and that of the other two groups (P=0.04). Conclusion: TENS is an effective and safe method for post-episiotomy pain relief and a routine method used in the obstetrics and gynecology ward. [GMJ.2019;8:e1404]

scholarly journals Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study

2021 ◽  
Vol 67 (4) ◽  
pp. 462-472
Author(s):  
Çağlar Karabaş ◽  
Havva Talay Çalış ◽  
Ulaş Serkan Topaloğlu ◽  
Çiğdem Karakükçü
Keyword(s):  
Range Of Motion ◽  
External Rotation ◽  
Platelet Rich Plasma ◽  
Adhesive Capsulitis ◽  
Controlled Study ◽  
Control Group ◽  
Plasma Injection ◽  
Active Flexion ◽  
Home Based ◽  
Significant Difference

Objectives: In this study, we aimed to investigate the effectiveness of intra-articular platelet-rich plasma (PRP) injection in adhesive capsulitis. Patients and methods: Between January 2019 and December 2019, a total of 40 patients (21 males, 19 females; mean age: 57.1±6.5 years; range, 44 to 72 years) with idiopathic adhesive capsulitis were included. The patients were randomly assigned into two equal groups as the PRP and the control group. The PRP group received two doses of PRP via intra-articular route biweekly under ultrasound guidance. No injection was performed to the control group. In both groups, stretching and Codman exercises were applied as a home- based program. The Visual Analog Scale (VAS), range of motion (ROM), and Shoulder Pain and Disability Index (SPADI) scores were evaluated before the treatment and at 2, 6 and 12 weeks after the treatment. Results: There were significant differences in all VAS, SPADI, and ROM scores at all time points after treatment compared to baseline in both groups. At the end of the study, there were significant differences in the active flexion, passive flexion, active abduction, passive abduction, and active external rotation scores at 12 weeks between the groups (p=0.012, p=0.015, p=0.008, p=0.019, and p=0.040, respectively). No significant difference was observed between the groups in terms of VAS and SPADI scores and the other parameters (active and passive extension, active and passive internal rotation, passive external rotation) at 2, 6, and 12 weeks (p>0.05). Conclusion: The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.

scholarly journals Effects of Music Intervention during Cesarean Section on the Level of the Mother’s Anxiety: A Randomized Controlled Study

2021 ◽  
Author(s):  
Jule Eriç Horasanlı ◽  
NUR DEMIRBAS
Keyword(s):  
Blood Pressure ◽  
Cesarean Section ◽  
Randomized Study ◽  
Intervention Group ◽  
Anxiety Score ◽  
Controlled Study ◽  
Control Group ◽  
Music Intervention ◽  
Significant Difference ◽  
Anxiety Levels

Background: Anxiety is commonly experienced during the delivery process and has been shown to have adverse effects on maternal and infant health outcomes. Music interventions tend to mitigate the effects of anxiety in a variety of populations, are low-cost and easily accessible, and have high acceptability. The aim of this study is to evaluate the effectiveness of music intervention on expectant mothers’ vital signs and anxiety levels during cesarean section. Methods: This study is a single-center, controlled, randomized study. The women in the intervention group listened to music via earpieces during the operation. The control group received standard treatment without music. Cesarean section was performed under regional anesthesia. The State-Trait Anxiety Inventory (STAI) was administered to the patients before and after the operation. Results: There was no significant difference between the pre- and postoperative systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, or O2 saturation parameters of the music group and the control group (p>0.05). The pre-operative STAI anxiety score was similar in the music (45.58±4.60) and control (43.82±4.33) groups (p=0.183). After the operation, the anxiety score of the music group (35.88±5.39) was found to be statistically significantly lower than the anxiety score of the control group (42.14±3.75) (p<0.001). Conclusion: This study supports the hypothesis that slow, rhythmic Sufi music during cesarean section can reduce patients’ anxiety. It is possible to distract the patient from negative thoughts and reduce stress. The results show that patients who listened to music during surgery had significantly lower anxiety levels than patients who did not listen to music.

A smartphone coaching program (“Bouge Grossesse”) improves daily physical activity in pregnant women (Preprint)

2021 ◽  
Author(s):  
Matthieu MULLER ◽  
Pandora JAMES ◽  
Philippe MERVIEL ◽  
Alain SARAUX ◽  
Yannick GUILLODO ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pregnant Women ◽  
Primary Outcome ◽  
Intervention Group ◽  
Daily Physical Activity ◽  
Controlled Study ◽  
Control Group ◽  
Sedentary Behaviors ◽  
Significant Difference ◽  
The Impact

BACKGROUND Physical activity has been shown to reduce obstetrical risks however pregnant women reduce their physical activity and sedentary behaviors increase. OBJECTIVE Our aim was to evaluate the impact of a smartphone application developed to increase daily physical activity in pregnant women. METHODS We enrolled 250 pregnant women in a prospective randomized controlled study. These women were instructed to download either an intervention application called «Bouge Grossesse» (coaching program and a pedometer; n=125) or a Placebo application (pedometer only; n=125). Primary outcome was defined as a daily increase of 2000 steps/day between day 1 and day 90 or 10 000 steps/week between week 1 and week 12. Data was analyzed with intention to treat. Secondary outcomes were the number of steps at week 12 and the evolution of quality of life measured by WHO score, EIFEL score and SPIEGEL scale, and on maternal and fetal outcomes. RESULTS Patients were enrolled between August 2017 and February 2019. They were retrospectively registered after September 2018. We found a significant difference in the primary outcome between the two groups in favor of the intervention group (22.4% success vs 3.2% in the control group, P<.001) but only 43 women in the intervention group (34.4%) and 16 women in the placebo group (12.8%) completed the 12-week coaching program. There were no significant differences in the SPIEGEL, EIFEL and WHO scores. The mean number of daily steps at week 12 was significantly higher in the intervention group (6900.0 vs 4371.9, P<.001). CONCLUSIONS The mobile health intervention « Bouge Grossesse » significantly increased physical activity in pregnant women but we observed a high percentage of withdrawals from the 12-week program. CLINICALTRIAL This clinical trial was registered under the number NCT03688087 ClinicalTrials.gov.

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