scholarly journals Anion-Dependent Synthesis of Cu(II) Complexes with 2-(1H-Tetrazol-5-yl)-1H-indole: Synthesis, X-Ray Structures, and Radical Scavenging Activity

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Petr Halaš ◽  
Juraj Kuchár ◽  
Radovan Herchel
Keyword(s):  
Theoretical Calculations ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
X Ray ◽  
X Ray Crystallography ◽  
Anionic Ligand ◽  
Vis Spectroscopy ◽  
Indole Synthesis

Two mononuclear Cu(II) complexes, [Cu(phen)2(HL)]ClO4·H2O·2DMF (1) and [Cu(phen)2(HL)2]·EtOH (2), comprising 1,10-phentantroline (phen) and 2-(1H-tetrazol-5-yl)-1H-indole ligand (H2L) ligands are reported. Analysis and characterization of the samples were performed using standard physicochemical techniques, elemental analysis, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and UV-vis spectroscopy. Single-crystal X-ray crystallography revealed the formation of a pentacoordinate complex in 1 and a hexacoordinate complex in 2, in which the anionic ligand HL− has undergone monodentate coordination through the tetrazole unit. Furthermore, the crystal structure of H2L·MeOH is also discussed. The potential application of compounds 1 and 2 in bioinorganic chemistry was addressed by investigating their radical scavenging activity with the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and the results were supported also by theoretical calculations.

scholarly journals Biochemical characterization of pink husked coconut types

2021 ◽  
pp. 72-76
Author(s):  
Regi J. Thomas ◽  
M. Shareefa ◽  
H. Harsha ◽  
Anitha Karun
Keyword(s):  
Biochemical Characterization ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenol Content ◽  
Anthocyanin Content ◽  
Scavenging Activity ◽  
Traditional Medicines ◽  
Ic50 Value ◽  
Morphological Differences

Coconuts with various traits are available in different coconut growing countries. The pink husk is one such trait that has already been reported in coconut. There is a demand for tender nut water from pink husked types of coconut to treat hepatitis by traditional medicinal practitioners. Present studies were carried out to characterize pink husked types identified in Guam Tall variety of coconut. There were no morphological differences with respect to the nut characters between pink and non-pink husked types. Biochemical characterization of pink husked types revealed significantly higher total phenol content in the tender nut water of pink husked types than normal husked types. A significantly higher protein content of 86 mg 100 mL-1 was noted in pink husked type, compared to normal husked type with 58.7 mg 100 mL-1. Higher free radical scavenging activity based on DPPH assay with pink husked type was recorded with an IC50 value of 266.7 compared to normal type with an IC50 value of 358. Similarly, phosphomolybdate assay also revealed higher scavenging activity of pink husked type based on the IC50 value of 415.2 compared to 637.9 observed in normal husked type. Anthocyanin content of 25.98 mg 100g-1 fresh weight was noted in the exocarp of pink husked types, and it was negligible in normal husked type. These results justify the use of pink husked coconuts in various traditional medicines. There is tremendous potential for exploiting pink husked types of coconut in the pharmaceutical industry.

scholarly journals Green Synthesis of Polymer-Capped Copper Nanoparticles Using Ocimum sanctum Leaf Extract: Antibacterial and Antioxidant Potential

2021 ◽  
Vol 14 (4) ◽  
pp. 1831-1838
Author(s):  
Chirag Makvana
Keyword(s):  
Copper Nanoparticles ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Ocimum Sanctum ◽  
Scavenging Activity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Uv Visible

The advancement of green nanotechnology has piqued the interest of researchers into the environmentally responsible production of nanoparticles. Conventionally used chemical methods for the synthesis of the nanoparticles have shown adverse effect on environment due to the use of highly toxic chemicals. They are also expensive as they utilize costly chemicals as a reducing and capping agent. Use of plant extract can be an environment friendly and cost-effective approach for the synthesis of nanoparticles. Copper is the metal which humans utilize from the ancient time period and it doesn’t show any adverse effect on humankind as well as on environment. Leaf extract of Ocimum sanctum was employed with CuSO4 (1:9, v/v) to synthesize stable copper nanoparticles (CuNPs) that were then functionalized with Polyvinyl Pyrrolidone (PVP) polymer. Characterization of synthesized copper nanoparticles was carried out using UV–Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). Synthesized CuNPs were subjected against the human pathogenic bacterial strain to evaluate their antibacterial potency. Antioxidative characteristics of CuNPs were analyzed using DPPH free radical scavenging activity. The UV–visible spectra of CuNPs showed unique peaks at 322 and 247 nm indicates the stable formation of nanoparticles. X-ray diffraction pattern suggest the face cubic centered (FCC) structure of copper nanoparticles. FTIR analysis revealed the presence of biomolecules attached on the surface of CuNPs. TEM analysis proven the synthesis of spherical shaped CuNPs with the average particle size of 73.50 ± 1.78 nm. Biosynthesized CuNPs showed maximum zone of inhibition against E. coli which was tends to be 20 mm. 51.48 % of DPPH free radical scavenging activity was observed by synthesized PVP coated CuNPs. As a result, this technology can be employed for the quick and environmentally friendly biosynthesis of stable copper nanoparticles with antibacterial and antioxidant activities with the size range from 10 to 100 nm, implying their potential application in the healthcare, clinical as well as pharmaceutical fields

Characterization of the superoxide anion radical scavenging activity by tetracycline antibiotics in aprotic media

Luminescence ◽  
2011 ◽  
Vol 26 (6) ◽  
pp. 611-615 ◽  
Author(s):  
Aleksandra Kładna ◽  
Irena Kruk ◽  
Teresa Michalska ◽  
Paweł Berczyński ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Scavenging Activity ◽  
Tetracycline Antibiotics

scholarly journals New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

2016 ◽  
Vol 12 ◽  
pp. 2077-2085 ◽  
Author(s):  
Ze’en Xiao ◽  
Senhua Chen ◽  
Runlin Cai ◽  
Shao’e Lin ◽  
Kui Hong ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Spectroscopic Data ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
X Ray ◽  
Mangrove Endophytic Fungus ◽  
The Absolute ◽  
Aspergillus Sp ◽  
First Time

The chemical investigation of the mangrove endophytic fungus Aspergillus sp. 085242 afforded eight isocoumarin derivatives 1–8 and one isoquinoline 9. Asperisocoumarins A and B (1 and 2) were new furoisocoumarins, and asperisocoumarins E and F (5 and 6) were new isocoumarins. Their structures were established by analysis of their spectroscopic data and the absolute configuration of compound 2 was unambiguously determined by X-ray structure analysis and ECD calculation. Moreover, the absolute configurations of compounds 3–5 were assigned by comparison of their ECD spectra with isocoumarins described in the literature. Asperisocoumarins C and D (3 and 4) were fully characterized spectroscopically and isolated from a natural source for the first time. Asperisocoumarins A–D (1–4) related to the class of furo[3,2-h]isocoumarins are rarely occurring in natural sources. Compounds 2, 5, and 6 showed moderate α-glucosidase inhibitory activity with IC50 of 87.8, 52.3, and 95.6 μM, respectively. In addition, compounds 1 and 3 exhibited weak radical scavenging activity with EC50 values of 125 and 138 μM, respectively.

Sign in / Sign up

Export Citation Format

Share Document