scholarly journals FK506 reduces liver ischemia-reperfusion injury in a rat model of autologous orthotopic liver transplantation by decreasing HMGB1 release

2017 ◽  
Vol 25 (4) ◽  
pp. 326
Author(s):  
Feng Chen ◽  
Jian Wang ◽  
Ya-Min Zhang
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Orthotopic Liver Transplantation ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

scholarly journals Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation

JCI Insight ◽  
2016 ◽  
Vol 1 (20) ◽  
Author(s):  
Rebecca A. Sosa ◽  
Ali Zarrinpar ◽  
Maura Rossetti ◽  
Charles R. Lassman ◽  
Bita V. Naini ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Orthotopic Liver Transplantation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion

Protocol for the pig liver ischemia/reperfusion injury

2020 ◽  
Author(s):  
Eric Felli ◽  
Mahdi Al-Taher ◽  
Emanuele Felli ◽  
Lorenzo Cinelli ◽  
Michele Diana
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Liver Damage ◽  
Porcine Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Graft Loss ◽  
Vascular Complication ◽  
Liver Ischemia ◽  
Pig Liver

Abstract Liver ischemia/reperfusion injury (IRI) is a dreadful vascular complication, which leads to liver damage. It is often associated with graft loss in liver transplantation and with a higher morbidity and mortality. IRI can have different causes, such as inflow clumping during surgical procedures in hepatic resection, liver transplantation, trauma, as well as during the stenosis of the vasculature caused by cancer. Here, we show a detailed IRI protocol in a porcine model.

Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation

PROTEOMICS ◽  
2006 ◽  
Vol 6 (11) ◽  
pp. 3455-3465 ◽  
Author(s):  
Carlo Vascotto ◽  
Laura Cesaratto ◽  
Chiara D'Ambrosio ◽  
Andrea Scaloni ◽  
Claudio Avellini ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Orthotopic Liver Transplantation ◽  
Proteomic Analysis ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Tissues

scholarly journals Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model

2019 ◽  
Vol 2 (3) ◽  
pp. 93-102
Author(s):  
Kerem Akkoca ◽  
Mustafa Sit ◽  
Hamit Yoldas ◽  
Ibrahim Karagoz ◽  
Isa Yildiz ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Magnesium Sulphate ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

scholarly journals Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model

2008 ◽  
Vol 23 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Antonio Roberto Franchi Teixeira ◽  
Nilza Trindade Molan ◽  
Marta Bellodi-Privato ◽  
Ana Maria Coelho ◽  
Kátia Ramos Leite ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Classical Model ◽  
Control Group ◽  
Standard Diet ◽  
Liver Ischemia ◽  
Hepatic Ischemia ◽  
Histological Assessment

PURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.

A Novel and Sensitive Approach for the Evaluation of Liver Ischemia-Reperfusion Injury After Liver Transplantation

2016 ◽  
Vol 51 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Martina Brandlhuber ◽  
Marco Armbruster ◽  
Blaž Zupanc ◽  
Paola Coan ◽  
Emmanuel Brun ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia
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