Transitional Cell Hyperplasia and Carcinomas in Urinary Bladders of Transgenic Mice with Keratin 5 Promoter-Driven Cyclooxygenase-2 Overexpression

2005 ◽  
Vol 65 (5) ◽  
pp. 1808-1813 ◽  
Author(s):  
Russell D. Klein ◽  
Carolyn S. Van Pelt ◽  
Anita L. Sabichi ◽  
Jorge dela Cerda ◽  
Susan M. Fischer ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Transitional Cell ◽  
Cyclooxygenase 2 ◽  
Cell Hyperplasia ◽  
Keratin 5

Preinvasive Duct-Derived Neoplasms in Pancreas of Keratin 5–Promoter Cyclooxygenase-2 Transgenic Mice

2006 ◽  
Vol 130 (7) ◽  
pp. 2165-2178 ◽  
Author(s):  
Karin Müller–Decker ◽  
Gerhard Fürstenberger ◽  
Nadine Annan ◽  
Dagmar Kucher ◽  
Andrea Pohl–Arnold ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cyclooxygenase 2 ◽  
Keratin 5

scholarly journals Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis

2019 ◽  
Vol 316 (1) ◽  
pp. G179-G186
Author(s):  
Haojie Huang ◽  
Jiaxiang Chen ◽  
Lisi Peng ◽  
Yao Yao ◽  
Defeng Deng ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Transgenic Mice ◽  
Fibrous Tissue ◽  
Acinar Cells ◽  
Cyclooxygenase 2 ◽  
Therapeutic Interventions ◽  
Pancreatic Stellate Cells ◽  
Pancreatic Acinar Cells ◽  
Transgenic Expression ◽  
Cox 2

Replacement of the exocrine parenchyma by fibrous tissue is a main characteristic of chronic pancreatitis. Understanding the mechanisms of pancreatic fibrogenesis is critical for the development of preventive and therapeutic interventions. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandin synthesis, is expressed in patients with chronic pancreatitis. However, it is unknown whether COX-2 can cause chronic pancreatitis. To investigate the roles of pancreatic acinar COX-2 in fibrogenesis and the development of chronic pancreatitis, COX-2 was ectopically expressed specifically in pancreatic acinar cells in transgenic mice. Histopathological changes and expression levels of several profibrogenic factors related to chronic pancreatitis were evaluated. COX-2 was expressed in the pancreas of the transgenic mice, as detected by Western blot analysis. Immunohistochemical staining showed COX-2 was specifically expressed in pancreatic acinar cells. COX-2 expression led to progressive changes in the pancreas, including pancreas megaly, persistent inflammation, collagen deposition, and acinar-to-ductal metaplasia. Quantitative RT-PCR and immunostaining showed that profibrogenic factors were upregulated and pancreatic stellate cells were activated in the COX-2 transgenic mice. Expression of COX-2 in pancreatic acinar cells is sufficient to induce chronic pancreatitis. Targeting this pathway may be valuable in the prevention of chronic pancreatitis. NEW & NOTEWORTHY COX-2 expression is observed in pancreatic tissues of human chronic pancreatitis. In this study, we showed that COX-2 expression caused the development of chronic pancreatitis in transgenic mice, supporting the idea that COX-2 inhibition may be an effective preventive and therapeutic strategy.

scholarly journals Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

1999 ◽  
Vol 155 (3) ◽  
pp. 995-1004 ◽  
Author(s):  
Kevin A. Kelley ◽  
Lap Ho ◽  
David Winger ◽  
Jose Freire-Moar ◽  
Cy Blanco Borelli ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cyclooxygenase 2

scholarly journals Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

2001 ◽  
Vol 21 (20) ◽  
pp. 8198-8209 ◽  
Author(s):  
Katrin I. Andreasson ◽  
Alena Savonenko ◽  
Sveta Vidensky ◽  
Joseph J. Goellner ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cognitive Deficits ◽  
Neuronal Apoptosis ◽  
Cyclooxygenase 2 ◽  
Age Dependent

scholarly journals Expression of Interleukin-9 Leads to Th2 Cytokine-Dominated Responses and Fatal Enteropathy in Mice with ChronicSchistosoma mansoni Infections

2000 ◽  
Vol 68 (10) ◽  
pp. 6005-6011 ◽  
Author(s):  
Padraic G. Fallon ◽  
Philip Smith ◽  
Emma J. Richardson ◽  
Frances J. Jones ◽  
Helen C. Faulkner ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interleukin 4 ◽  
Moderate Increase ◽  
Wild Type ◽  
Schistosome Infection ◽  
Cell Hyperplasia ◽  
Necrosis Factor Alpha ◽  
Th2 Cytokine ◽  
Mucin Expression

ABSTRACT Mice infected with Schistosoma mansoni develop Th2 cytokine-mediated granulomatous pathology that is focused on the liver and intestines. In this study, transgenic mice constitutively expressing IL-9 were infected with S. mansoni and the outcome of infection was determined. Eight weeks after infection, transgenic mice with acute infections had a moderate increase in Th2 cytokine production but were overtly normal with respect to parasite infection and pathological responses. Transgenic mice with chronic infections died 10 weeks after infection, with 86% of transgenic mice dead by week 12 of infection, compared to 7% mortality in infected wild-type mice. Stimulation of mesenteric lymph node cells from infected transgenic mice with parasite antigen elicited elevated interleukin-4 (IL-4) and IL-5 production and reduced gamma interferon and tumor necrosis factor alpha production compared to the responses in wild-type mice. Morbid transgenic mice had substantial enlargement of the ileum, which was associated with muscular hypertrophy, mastocytosis, eosinophilia, goblet cell hyperplasia, and increased mucin expression. We also observed that uninfected transgenic mice exhibited alterations in their intestines. Although there was hepatic mastocytosis and eosinophilia in infected transgenic mice, there was no hepatocyte damage. Death of transgenic mice expressing IL-9 during schistosome infection was primarily associated with enteropathy. This study highlights the pleiotropic in vivo activity of IL-9 and demonstrates that an elevated Th2 cytokine phenotype leads to death during murine schistosome infection.

scholarly journals Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

2001 ◽  
Vol 98 (13) ◽  
pp. 7629-7634 ◽  
Author(s):  
G. Neufang ◽  
G. Furstenberger ◽  
M. Heidt ◽  
F. Marks ◽  
K. Muller-Decker
Keyword(s):  
Transgenic Mice ◽  
Cyclooxygenase 2
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