scholarly journals Unconventional Role of the Inwardly Rectifying Potassium Channel Kir2.2 as a Constitutive Activator of RelA in Cancer

2012 ◽  
Vol 73 (3) ◽  
pp. 1056-1062 ◽  
Author(s):  
Inkyoung Lee ◽  
Sook-Ja Lee ◽  
Tong Mook Kang ◽  
Won Ki Kang ◽  
Chaehwa Park
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying

scholarly journals Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Ori J Lieberman ◽  
Micah D Frier ◽  
Avery F McGuirt ◽  
Christopher J Griffey ◽  
Elizabeth Rafikian ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Dendritic Structure ◽  
Intrinsic Excitability ◽  
Projection Neurons ◽  
Inwardly Rectifying Potassium Channel ◽  
Cell Type Specific ◽  
Subcortical Nuclei ◽  
Specific Regulation ◽  
Inwardly Rectifying

The basal ganglia are a group of subcortical nuclei that contribute to action selection and reinforcement learning. The principal neurons of the striatum, spiny projection neurons of the direct (dSPN) and indirect (iSPN) pathways, maintain low intrinsic excitability, requiring convergent excitatory inputs to fire. Here, we examined the role of autophagy in mouse SPN physiology and animal behavior by generating conditional knockouts of Atg7 in either dSPNs or iSPNs. Loss of autophagy in either SPN population led to changes in motor learning but distinct effects on cellular physiology. dSPNs, but not iSPNs, required autophagy for normal dendritic structure and synaptic input. In contrast, iSPNs, but not dSPNs, were intrinsically hyperexcitable due to reduced function of the inwardly rectifying potassium channel, Kir2. These findings define a novel mechanism by which autophagy regulates neuronal activity: control of intrinsic excitability via the regulation of potassium channel function.

scholarly journals Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K+ excretion

2019 ◽  
Vol 316 (3) ◽  
pp. F582-F586 ◽  
Author(s):  
Xiao-Tong Su ◽  
David H. Ellison ◽  
Wen-Hui Wang
Keyword(s):  
Angiotensin Ii ◽  
Potassium Channel ◽  
Metabolic Alkalosis ◽  
Potassium Conductance ◽  
Thick Ascending Limb ◽  
Potassium Intake ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying

The aim of this mini review is to provide an overview regarding the role of inwardly rectifying potassium channel 4.1 (Kir4.1)/Kir5.1 in regulating renal K+ excretion. Deletion of Kir4.1 in the kidney inhibited thiazide-sensitive NaCl cotransporter (NCC) activity in the distal convoluted tubule (DCT) and slightly suppressed Na-K-2Cl cotransporter (NKCC2) function in the thick ascending limb (TAL). Moreover, increased dietary K+ intake inhibited, whereas decreased dietary K+ intake stimulated, the basolateral potassium channel (a Kir4.1/Kir5.1 heterotetramer) in the DCT. The alteration of basolateral potassium conductance is essential for the effect of dietary K+ intake on NCC because deletion of Kir4.1 in the DCT abolished the effect of dietary K+ intake on NCC. Since potassium intake-mediated regulation of NCC plays a key role in regulating renal K+ excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K+ intake. Finally, recent studies have suggested that the angiotensin II type 2 receptor (AT2R) and bradykinin-B2 receptor (BK2R) are involved in mediating the effect of high dietary K+ intake on Kir4.1/Kir5.1 in the DCT.

The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2→p11.1

1997 ◽  
Vol 79 (1-2) ◽  
pp. 85-87 ◽  
Author(s):  
N. Namba ◽  
R. Mori ◽  
H. Tanaka ◽  
I. Kondo ◽  
K. Narahara ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying

scholarly journals NovelKCNJ10Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1

2016 ◽  
Vol 291 (14) ◽  
pp. 7716-7726 ◽  
Author(s):  
Miguel P. Méndez-González ◽  
Yuriy V. Kucheryavykh ◽  
Astrid Zayas-Santiago ◽  
Wanda Vélez-Carrasco ◽  
Gerónimo Maldonado-Martínez ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying
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