scholarly journals Combination Analysis of Activator Protein-1 Family Members, Sp1 and an Activator Protein-2α-Related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers

2005 ◽  
Vol 11 (24) ◽  
pp. 8538-8548 ◽  
Author(s):  
Denis Martin Schewe ◽  
Tobias Biller ◽  
Gabriele Maurer ◽  
Irfan A. Asangani ◽  
Joerg H. Leupold ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Family Members ◽  
Urokinase Receptor ◽  
Colorectal Cancers ◽  
Related Factor ◽  
Activator Protein 1 ◽  
Factor Binding ◽  
Activator Protein

scholarly journals Src Induces Urokinase Receptor Gene Expression and Invasion/Intravasation via Activator Protein-1/p-c-Jun in Colorectal Cancer

2007 ◽  
Vol 5 (5) ◽  
pp. 485-496 ◽  
Author(s):  
Jörg H. Leupold ◽  
Irfan Asangani ◽  
Gabriele D. Maurer ◽  
Ernst Lengyel ◽  
Stefan Post ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Receptor Gene ◽  
Urokinase Receptor ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Receptor Gene Expression

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of

scholarly journals c-Jun N-Terminal Kinase Activation of Activator Protein-1 Underlies Homologous Regulation of the Gonadotropin-Releasing Hormone Receptor Gene in αT3-1 Cells

Endocrinology ◽  
2003 ◽  
Vol 144 (3) ◽  
pp. 839-849 ◽  
Author(s):  
Buffy S. Ellsworth ◽  
Brett R. White ◽  
Ann T. Burns ◽  
Brian D. Cherrington ◽  
Annette M. Otis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase ◽  
Cell Model ◽  
Receptor Gene ◽  
Critical Role ◽  
Dominant Negative ◽  
Activator Protein 1 ◽  
Activator Protein

Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homologous regulation of the GnRHR is an important mechanism underlying gonadotrope sensitivity to GnRH. Previously, we have found that GnRH induction of GnRHR gene expression in αT3-1 cells is partially mediated by protein kinase C activation of a canonical activator protein-1 (AP-1) element. In contrast, protein kinase A and a cAMP response element-like element have been implicated in mediating the GnRH response of the GnRHR gene using a heterologous cell model (GGH3). Herein we find that selective removal of the canonical AP-1 site leads to a loss of GnRH regulation of the GnRHR promoter in transgenic mice. Thus, an intact AP-1 element is necessary for GnRH responsiveness of the GnRHR gene both in vitro and in vivo. Based on in vitro analyses, GnRH appeared to enhance the interaction of JunD, FosB, and c-Fos at the GnRHR AP-1 element. Although enhanced binding of cFos reflected an increase in gene expression, GnRH appeared to regulate both FosB and JunD at a posttranslational level. Neither overexpression of a constitutively active Raf-kinase nor pharmacological blockade of GnRH-induced ERK activation eliminated the GnRH response of the GnRHR promoter. GnRH responsiveness was, however, lost in αT3-1 cells that stably express a dominant-negative c-Jun N-terminal kinase (JNK) kinase, suggesting a critical role for JNK in mediating GnRH regulation of the GnRHR gene. Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components.

Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms

2016 ◽  
Vol 17 (3) ◽  
pp. 291-304 ◽  
Author(s):  
Alexandra Papoudou-Bai ◽  
Eleftheria Hatzimichael ◽  
Alexandra Barbouti ◽  
Panagiotis Kanavaros
Keyword(s):  
Expression Patterns ◽  
Family Members ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Lymphoid Neoplasms

scholarly journals Expression of activator protein-1 (AP-1) family members in breast cancer

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Amirhossein Kharman-Biz ◽  
Hui Gao ◽  
Reza Ghiasvand ◽  
Chunyan Zhao ◽  
Kazem Zendehdel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family Members ◽  
Activator Protein 1 ◽  
Activator Protein

scholarly journals Differential Activation of the Connexin 43 Promoter by Dimers of Activator Protein-1 Transcription Factors in Myometrial Cells

Endocrinology ◽  
2005 ◽  
Vol 146 (4) ◽  
pp. 2048-2054 ◽  
Author(s):  
Jennifer A. Mitchell ◽  
Stephen J. Lye
Keyword(s):  
Transcription Factors ◽  
Connexin 43 ◽  
Family Members ◽  
Expression Vectors ◽  
Central Component ◽  
Activator Protein 1 ◽  
Cx43 Expression ◽  
Myometrial Cells ◽  
Activator Protein ◽  
Expression Of Genes

Abstract The expression of activator protein-1 (AP-1) transcription factors is increased in the myometrium at term and may therefore regulate the expression of genes, such as connexin 43 (Cx43), required for the onset of labor. The region upstream of the mouse, rat, and human Cx43 genes contains two consensus AP-1 binding sequences, a proximal AP-1, located close to the TATA box, and a distal AP-1, 1 kb upstream. A transient transfection system was developed in which Syrian hamster myometrial cells were transfected with Cx43 promoter-luciferase constructs in combination with expression vectors for the AP-1 family. Transfection with c-Jun or JunB had no effect on transcription from the Cx43 promoter, whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription. Deletion of the distal AP-1 site did not abrogate transcription driven by Fos/Jun, whereas a 2-bp mutation in the proximal AP-1 site significantly reduced pCx43 transactivation by AP-1 dimers. Dimers comprising Fos/Jun proteins conferred greater transcriptional activity than Jun dimmers, with Fra-2/JunB combination conferring greatest activity. These data suggest that increased expression of Fos family members in the myometrium at term drives the increase in Cx43 transcription and expression during labor. Because expression of Fra-2 increases earlier than other Fos family members and confers the highest transcriptional drive to the Cx43 promoter, our data suggest that Fra-2 is a central component in the regulation of Cx43 expression during labor.

Parathyroid Hormone versus Phorbol Ester Stimulation of Activator Protein-1 Gene Family Members in Rat Osteosarcoma Cells

1997 ◽  
Vol 61 (1) ◽  
pp. 52-58 ◽  
Author(s):  
R. C. Koe ◽  
J. C. Clohisy ◽  
D. R. Tyson ◽  
M. R. Pulumati ◽  
T. F. Cook ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Gene Family ◽  
Phorbol Ester ◽  
Family Members ◽  
Activator Protein 1 ◽  
Osteosarcoma Cells ◽  
Activator Protein ◽  
Stimulation Of
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