Association of cardiovascular disease risk factors with late cardiotoxicity and survival in HER2-positive breast cancer survivors

2021 ◽  
pp. clincanres.4162.2020
Author(s):  
Xuexin He ◽  
Jiali Ji ◽  
Xiaolan Dai ◽  
Aiham Z. Qdaisat ◽  
Francisco J. Esteva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Her2 Positive ◽  
Late Cardiotoxicity ◽  
Positive Breast Cancer

scholarly journals Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

2020 ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

scholarly journals Aerobic and resistance exercise improves Reynolds risk score in overweight or obese breast cancer survivors

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and results One hundred overweight or obese (BMI > 25 kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9 ± 0.9% to 1.0 ± 0.5%; p < 0.001) in the exercise group compared to a significant increase (9.0 ± 0.8% to 11.6 ± 1.2%; p = 0.002%) in the usual care group (p < 0.01). RRS was significantly reduced in exercise vs usual care (between group difference, − 10.6; 95% CI, − 16.3 to − 7.4; p < 0.001). Conclusion A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors. Trial registration ClinicalTrials.gov: NCT01140282. Registered 9 June 2010

scholarly journals Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer

Sports ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 80
Author(s):  
Gabriel H. Zieff ◽  
Chad W. Wagoner ◽  
Craig Paterson ◽  
Patricia Pagan Lassalle ◽  
Jordan T. Lee
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Skeletal Muscle ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Breast Cancer Survivors ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Intolerance ◽  
Peak Oxygen Consumption

Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk.

scholarly journals Cardiovascular disease risk among breast cancer survivors: an evolutionary concept analysis

2017 ◽  
Vol Volume 7 ◽  
pp. 9-16 ◽  
Author(s):  
Jacqueline B Vo ◽  
Timiya S Nolan ◽  
David E Vance ◽  
Patricia A Patrician ◽  
Karen Meneses
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Concept Analysis
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