Abstract A62: A novel Eg5 inhibitor that causes mitotic arrest leading to rapid cancer cell death shows broad‐spectrum antitumor activity in preclinical xenograft tumor models

2009 ◽  
Author(s):  
Xiang S. Ye ◽  
Li Fan ◽  
Robert Van Horn ◽  
Tinggui Yin ◽  
Ryuichiro Nakai ◽  
...  
Keyword(s):  
Cell Death ◽  
Antitumor Activity ◽  
Cancer Cell ◽  
Broad Spectrum ◽  
Mitotic Arrest ◽  
Xenograft Tumor ◽  
Tumor Models ◽  
Cancer Cell Death ◽  
Eg5 Inhibitor

scholarly journals A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin

Cell Division ◽  
2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Gianandrea Traversi ◽  
David Sasah Staid ◽  
Mario Fiore ◽  
Zulema Percario ◽  
Daniela Trisciuoglio ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Mitotic Arrest ◽  
Cancer Cell Death ◽  
Resveratrol Derivative

Activity-based protein profiling reveals GSTO1 as the covalent target of piperlongumine and a promising target for combination therapy for cancer

2019 ◽  
Vol 55 (30) ◽  
pp. 4407-4410 ◽  
Author(s):  
Li Li ◽  
Yue Zhao ◽  
Ran Cao ◽  
Lin Li ◽  
Gaihong Cai ◽  
...  
Keyword(s):  
Cell Death ◽  
Combination Therapy ◽  
Synergistic Effect ◽  
Cancer Cell ◽  
Broad Spectrum ◽  
Protein Profiling ◽  
Cancer Cell Death ◽  
Promising Target ◽  
Anti Cancer

Through ABPP, piperlongumine was identified to induce cancer cell death by covalently binding and inhibiting GSTO1 and has a broad spectrum synergistic effect with other anti-cancer agents.

New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death

2016 ◽  
Vol 23 (15) ◽  
pp. 1513-1527 ◽  
Author(s):  
Magdalena Gorska ◽  
Alicja Kuban-Jankowska ◽  
Jaroslaw Slawek ◽  
Michal Wozniak
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Insight Into

Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy

2019 ◽  
Vol 234 (11) ◽  
pp. 20648-20661 ◽  
Author(s):  
Zhen Yu ◽  
Ze Yu ◽  
ZhenBao Chen ◽  
Lin Yang ◽  
MingJun Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Death ◽  
Zinc Chelator

scholarly journals Discovery of pyrano[2,3-d]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4454-4464
Author(s):  
Nour E. A. Abd El-sattar ◽  
Eman H. K. Badawy ◽  
Eman Z. Elrazaz ◽  
Nasser S. M. Ismail
Keyword(s):  
Cell Death ◽  
Dna Repair ◽  
Antitumor Activity ◽  
Cancer Cell ◽  
Cytotoxic Agents ◽  
Repair Mechanism ◽  
Design Synthesis ◽  
Parp 1

PARP-1 are involved in DNA repair damage and so PARP-1 inhibitors have been used as potentiators in combination with DNA damaging cytotoxic agents to compromise the cancer cell DNA repair mechanism, resulting in genomic dysfunction and cell death.

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