Abstract C021: Validation of the interaction between a candidate compound and the intended drug target by a phenotypic rescue approach

2019 ◽  
Author(s):  
Laure Grandmoursel ◽  
Lieke Geerts ◽  
Geraldine Servant ◽  
Miranda van der Ham ◽  
Armin Maier ◽  
...  
Keyword(s):  
Drug Target ◽  
Phenotypic Rescue

Abstract 1265: Validation of the interaction between a candidate compound and the intended drug target by a phenotypic rescue approach

2019 ◽  
Author(s):  
Lieke Geerts ◽  
Laure Grandmoursel ◽  
Jamil Aarbiou ◽  
Jeroen DeGroot ◽  
Julia Schüler ◽  
...  
Keyword(s):  
Drug Target ◽  
Phenotypic Rescue

Abstract 1265: Validation of the interaction between a candidate compound and the intended drug target by a phenotypic rescue approach

2019 ◽  
Author(s):  
Lieke Geerts ◽  
Laure Grandmoursel ◽  
Jamil Aarbiou ◽  
Jeroen DeGroot ◽  
Julia Schüler ◽  
...  
Keyword(s):  
Drug Target ◽  
Phenotypic Rescue

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

CGMP as a New Drug Target in Atrial Fibrillation

2020 ◽  
Author(s):  
N. I. Bork ◽  
N. Grammatika-Pavlidou ◽  
B. Reiter ◽  
E. Girdauskas ◽  
H. Reichenspurner ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Target ◽  
New Drug

Cyclin dependent kinase 4 as promising drug target in adrenocortical carcinoma

2019 ◽  
Author(s):  
Raimunde Liang ◽  
Isabel Weigand ◽  
Silviu Sbiera ◽  
Stefan Kircher ◽  
Juliane Lippert ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Drug Target ◽  
Cyclin Dependent Kinase
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