Abstract P3-08-02: Multi-gene panel testing for hereditary cancer predisposition in unsolved high risk breast and ovarian cancer patients

2017 ◽  
Author(s):  
BB Crawford ◽  
SB Adams ◽  
T Sittler ◽  
J Van den Akker ◽  
SB Chan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Breast And Ovarian Cancer ◽  
Panel Testing ◽  
Gene Panel Testing ◽  
High Risk Breast ◽  
Hereditary Cancer Predisposition

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients

2011 ◽  
Vol 33 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Ella R. Thompson ◽  
Samantha E. Boyle ◽  
Julie Johnson ◽  
Georgina L. Ryland ◽  
Sarah Sawyer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer ◽  
High Risk Breast

scholarly journals Gene-panel testing of breast and ovarian cancer patients identifies a recurrentRAD51Cduplication

2018 ◽  
Vol 93 (3) ◽  
pp. 595-602 ◽  
Author(s):  
L.M. Pelttari ◽  
H. Shimelis ◽  
H. Toiminen ◽  
A. Kvist ◽  
T. Törngren ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Gene Panel ◽  
Breast And Ovarian Cancer ◽  
Panel Testing ◽  
Gene Panel Testing

CHEK2 gene analysis in 1020 high-risk breast and ovarian cancer patients in the Czech Republic

2016 ◽  
Vol 61 ◽  
pp. S27
Author(s):  
L. Stolarova ◽  
P. Kleiblova ◽  
P. Zemankova ◽  
M. Janatova ◽  
M. Borecka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Czech Republic ◽  
High Risk ◽  
Cancer Patients ◽  
Gene Analysis ◽  
Breast And Ovarian Cancer ◽  
The Czech Republic ◽  
Chek2 Gene ◽  
High Risk Breast

scholarly journals A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist-or Genetic Counselor-Mediated Model of Care

2021 ◽  
Vol 28 (2) ◽  
pp. 1459-1471
Author(s):  
Jeanna M McCuaig ◽  
Emily Thain ◽  
Janet Malcolmson ◽  
Sareh Keshavarzi ◽  
Susan Randall Armel ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Genetic Testing ◽  
Cancer Patients ◽  
Genetic Counselor ◽  
Clear Understanding ◽  
Breast And Ovarian Cancer ◽  
Panel Testing ◽  
Gene Panel Testing ◽  
Patient Reported ◽  
Post Test

This study compares knowledge, experience and understanding of genetic testing, and psychological outcomes among breast and ovarian cancer patients undergoing multi-gene panel testing via genetic counselor-mediated (GMT) or oncologist-mediated (OMT) testing models. A pragmatic, prospective survey of breast and ovarian cancer patients pursuing genetic testing between January 2017 and August 2019 was conducted at the Princess Margaret Cancer Centre in Toronto, Canada. A total of 120 (80 GMT; 40 OMT) individuals completed a survey administered one week following consent to genetic testing. Compared to OMT, the GMT cohort had higher median knowledge (8 vs. 9; p = 0.025) and experience/understanding scores (8.5 vs. 10; p < 0.001) at the time of genetic testing. Significant differences were noted in the potential psychological concerns experienced, with individuals in the GMT cohort more likely to screen positive in the hereditary predisposition domain of the Psychosocial Aspects of Hereditary Cancer tool (55% vs. 27.5%; p = 0.005), and individuals in the OMT cohort more likely to screen positive in the general emotions domain (65.0% vs. 38.8%; p = 0.007). The results of this study suggest that OMT can be implemented to streamline genetic testing; however, post-test genetic counseling should remain available to all individuals undergoing genetic testing, to ensure any psychologic concerns are addressed and that individuals have a clear understanding of relevant implications and limitations of their test results.

The yield of full BRCA1/2 genotyping in Israeli high-risk breast/ovarian cancer patients who do not carry the predominant mutations

2018 ◽  
Vol 172 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Inbal Barnes-Kedar ◽  
Rinat Bernstein-Molho ◽  
Nava Ginzach ◽  
Shulamit Hartmajer ◽  
Tamar Shapira ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
High Risk Breast

Clinical impact of multi-gene panel testing for hereditary breast and ovarian cancer risk assessment.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1513-1513
Author(s):  
Leif W. Ellisen ◽  
Allison W. Kurian ◽  
Andrea J Desmond ◽  
Meredith Mills ◽  
Stephen E Lincoln ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Risk Assessment ◽  
Cancer Risk ◽  
Clinical Impact ◽  
Gene Panel ◽  
Cancer Risk Assessment ◽  
Ovarian Cancer Risk ◽  
Breast And Ovarian Cancer ◽  
Panel Testing ◽  
Gene Panel Testing
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