Abstract PO-139: BRCA sequence variants in breast cancer patients with African ancestry

2022 ◽  
Author(s):  
Solange Bayard ◽  
Rachel Martini ◽  
Yalei Chen ◽  
Brittany Jenkins ◽  
Isra Elhussin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
African Ancestry ◽  
Sequence Variants ◽  
Breast Cancer Patients

BRCA1/2 mutation prevalence among triple-negative breast cancer patients from a large commercial testing cohort.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1544-1544 ◽  
Author(s):  
Kristilyn Dillman Zonno ◽  
Rajesh R. Kaldate ◽  
Christopher Arnell ◽  
Jennifer Saam ◽  
Brian Abbott ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
African Ancestry ◽  
Parp Inhibitors ◽  
Ashkenazi Jewish ◽  
Breast Cancer Patients ◽  
Cancer Network ◽  
Testing Criteria

1544 Background: BRCA1/2 deleterious mutation identification among triple-negative breast cancer (TNBC) patients has gained importance due to cancer-risk management implications for patients and their relatives, and also has an emerging role in guiding treatment selection for therapies such as PARP inhibitors. The National Comprehensive Cancer Network (NCCN) currently recommends BRCA1/2 testing for TNBC patients diagnosed at age <60. Mutation prevalence among TNBC patients has previously been studied only in small regionalized cohorts. A recent study in unselected patients using the updated definitive criteria for TNBC reported mutation prevalence as 10.6%. Methods: Following the 2011 NCCN Hereditary Breast and Ovarian Cancer (HBOC) Testing Criteria update, serial cohorts of > 5,000 Ashkenazi Jewish and > 65,000 non-Ashkenazi Jewish breast cancer patients undergoing commercial BRCA1/2 testing were analyzed. Age at diagnosis, ethnicity, and provider-reported TN status were obtained from test requisition forms completed by ordering providers, and correlated with test results. Neither the accuracy nor definitive criteria used for TN status reported was independently verified. Results: Incidence of TNBC was reported as 9.7% among non-Ashkenazi patients and 16.5% within the subset with African ancestry. Incidence of TNBC was reported as 4.5% among Ashkenazi patients, but this is likely affected by test ordering for this population. The Table displays the BRCA1/2mutation rates classified by ethnicity and age-group. Conclusions: This study provides the most robust estimate to date of BRCA1/2 mutation prevalence among TNBC patients of all ages. The mutation rates seen among TNBC patients diagnosed after age 60 also illustrate the importance of testing such patients who may not meet the current NCCN HBOC testing criteria. [Table: see text]

ATM sequence variants and adverse radiotherapy response in breast cancer patients

2004 ◽  
Vol 60 ◽  
pp. S207-S208
Author(s):  
B ROSENSTEIN ◽  
C ANDREASSEN ◽  
J ALSNER ◽  
M OVERGAARD ◽  
J CESARETTI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Sequence Variants ◽  
Breast Cancer Patients

Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry

2012 ◽  
Vol 134 (2) ◽  
pp. 889-894 ◽  
Author(s):  
Jing Zhang ◽  
James D. Fackenthal ◽  
Yonglan Zheng ◽  
Dezheng Huo ◽  
Ningqi Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
African Ancestry ◽  
Breast Cancer Patients ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals Novel sequence variants and common recurrent polymorphisms of BRCA2 in Sri Lankan breast cancer patients and a family with BRCA1 mutations

2011 ◽  
Vol 2 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
SUMADEE DE SILVA ◽  
KAMANI H. TENNEKOON ◽  
ERIC H. KARUNANAYAKE ◽  
WASANTHI DE SILVA ◽  
INDRANI AMARASINGHE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Sequence Variants ◽  
Sri Lankan ◽  
Breast Cancer Patients ◽  
Brca1 Mutations

scholarly journals Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1gene in Sri Lankan breast cancer patients and at risk individuals

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Wasanthi De Silva ◽  
Eric H Karunanayake ◽  
Kamani H Tennekoon ◽  
Marie Allen ◽  
Indrani Amarasinghe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Cancer Patients ◽  
High Frequency ◽  
Sequence Variants ◽  
Sri Lankan ◽  
Breast Cancer Patients

Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors

1996 ◽  
Vol 108 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Hirotaka Iwase ◽  
Jill M. Greenman ◽  
Diana M. Barnes ◽  
Shirley Hodgson ◽  
Lynda Bobrow ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Cancer Patients ◽  
Sequence Variants ◽  
Breast Cancer Patients

PALB2 sequence variants in young South African breast cancer patients

2009 ◽  
Vol 8 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Michelle Sluiter ◽  
Samantha Mew ◽  
Elizabeth J. van Rensburg
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
South African ◽  
Sequence Variants ◽  
Breast Cancer Patients

ATM sequence variants and adverse radiotherapy response in breast cancer patients

2004 ◽  
Vol 60 (1) ◽  
pp. S207-S208 ◽  
Author(s):  
B.S. Rosenstein ◽  
C.N. Andreassen ◽  
J. Alsner ◽  
M. Overgaard ◽  
J.A. Cesaretti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Sequence Variants ◽  
Breast Cancer Patients
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