scholarly journals The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

2014 ◽  
Vol 12 (4) ◽  
pp. 527-538 ◽  
Author(s):  
Syng-Ook Lee ◽  
Un-Ho Jin ◽  
Jeong Han Kang ◽  
Sang Bae Kim ◽  
Aaron S. Guthrie ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Nuclear Receptor ◽  
Orphan Nuclear Receptor ◽  
Pancreatic Cancer Cells

scholarly journals Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells

2012 ◽  
Vol 10 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Elena V. Sheveleva ◽  
Terry H. Landowski ◽  
Betty K. Samulitis ◽  
Geoffrey Bartholomeusz ◽  
Garth Powis ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Endoplasmic Reticulum Stress Response ◽  
Pancreatic Cancer Cells

scholarly journals Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis

2005 ◽  
Vol 65 (24) ◽  
pp. 11658-11666 ◽  
Author(s):  
Steffan T. Nawrocki ◽  
Jennifer S. Carew ◽  
Maria S. Pino ◽  
Ralph A. Highshaw ◽  
Kenneth Dunner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells

scholarly journals Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2316
Author(s):  
Hyo-Seon Lee ◽  
Soo-Hyun Kim ◽  
Bo-Mi Kim ◽  
Stephen Safe ◽  
Syng-Ook Lee
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Nuclear Receptor ◽  
Human Pancreatic Cancer ◽  
Orphan Nuclear Receptor ◽  
Apoptotic Pathway ◽  
Pancreatic Cancer Cells ◽  
Apoptotic Protein ◽  
Apoptotic Pathways ◽  
Specificity Protein

The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth. In this study, we identified broussochalcone A (BCA) as a new NR4A1 inhibitor and demonstrated that BCA inhibits cell growth partly by inducing NR4A1-mediated apoptotic pathways in human pancreatic cancer cells. BCA downregulated specificity protein 1 (Sp1)-mediated expression of an anti-apoptotic protein, survivin, and activated the endoplasmic reticulum (ER) stress-mediated apoptotic pathway. These results suggest that NR4A1 inactivation contributes to the anticancer effects of BCA, and that BCA represents a potential anticancer agent targeting NR4A1 that is overexpressed in many types of human cancers.

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