Abstract PO-062: Why drug and radiation combination synergism or antagonism can be quantitatively determined with the mass-action law based pharmacodynamics equation, algorithm and computer simulation

2021 ◽  
Author(s):  
Ting-Chao Chou
Keyword(s):  
Computer Simulation ◽  
Mass Action ◽  
Mass Action Law

Studies on Activator Formation in Human Plasma with Streptokinase

1973 ◽  
Vol 30 (02) ◽  
pp. 381-392
Author(s):  
M Martin ◽  
Keyword(s):  
Human Plasma ◽  
Plasminogen Activator ◽  
Mass Action ◽  
Activator Concentration ◽  
Kinetic Effect ◽  
Mass Action Law

SummaryThe plasminogen-streptokinase complex called “activator” was present in diluted plasma in the form of a largely dissociated mixture. More than ⅞ of the streptokinase and plasminogen molecules were available for further activator formation.The activator is probably a dissociated complex of the formulaStreptokinase + Plasminogen ⇄ Activator.The fact that an increase in activator concentration by x times is obtained by multiplying either the streptokinase content by the factor y or the plasminogen concentration by the same factor y would point to a kinetic effect along the lines of the mass action law.

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