scholarly journals Licochalcone E Present in Licorice Suppresses Lung Metastasis in the 4T1 Mammary Orthotopic Cancer Model

2013 ◽  
Vol 6 (6) ◽  
pp. 603-613 ◽  
Author(s):  
Soo Jin Kwon ◽  
So Young Park ◽  
Gyoo Taik Kwon ◽  
Ki Won Lee ◽  
Young-Hee Kang ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Cancer Model ◽  
Licochalcone E

scholarly journals Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model

2014 ◽  
Vol 15 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Man Jiang ◽  
Xiaoya Xu ◽  
Yuli Bi ◽  
Jiying Xu ◽  
Chengyong Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Systemic Inflammation ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

R413 – KITENIN Enhances Invasion and Metastasis in FOM Cancer Model

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P181-P182
Author(s):  
Joon Kyoo Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Salivary Gland ◽  
Cell Carcinoma ◽  
Lung Metastasis ◽  
Squamous Cell ◽  
Tumor Invasion ◽  
Lung Metastases ◽  
Cancer Model ◽  
Floor Of Mouth ◽  
Diffuse Lung

Problem KAI1 is a metastatic suppressor gene. The expression of KAI1 in cancer cells results in reduced cell motility and invasiveness. A cDNA clone of VANGL1, a member of the tetraspanin protein family that specifically interacts with the COOH-terminal cytoplasm domain of KAI1, was isolated and renamed KITENIN (KAI1 COOH-terminal interacting tetraspanin). KITENIN is reported to promote metastasis in a mouse colon cancer model. The purpose of this study was to investigate tumor invasiveness and early lung metastasis by KITENIN in murine floor of mouth cancer model. Methods The cDNA of KITENIN and the vector only were transfected into the SCC VII (mouse squamous cell carcinoma cell line) cells. The transfections were performed using the FuGENE 6 transfection reagent. The suspension of 5 × 105/? viable KITENIN- or vector-transfected SCC VII cells were injected into the floor of mouth of C3H/HeJ syngeneic mice deep to the mylohyoid muscle via an intra-oral approach. From the 1st week to 6th week after injection, tumor, lung, liver, and brain tissues were obtained from six mice each group every week and were evaluated under the light microscope. Results On each group, the tumor invaded to superficial musculature of floor of mouth, deep musculature of floor of mouth, salivary gland, perineural tissue, bone, and skin sequentially. Lung metastases started from peripheral and localized region and moved to central and diffuse lung tissues. Earlier and more aggressive tumor invasion to deep floor of mouth musculature, salivary gland, perineural tissue, bone, and skin was observed in KITENIN-transfected group than in vector group. Earlier and more diffuse lung metastasis was observed in KITENIN group. Conclusion KITENIN enhanced tumor invasion and lung metastasis in murine floor of mouth squamous carcinoma model. Significance An antisense KITENIN strategy could be used to inhibit distant metastasis and progression in head and neck squamous cell carcinoma. Support This study was supported by a grant CUHRICM-CRI07038-1.

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model

10.3791/61805 ◽  
2020 ◽  
Author(s):  
Margaret A. Nagai-Singer ◽  
Alissa Hendricks-Wenger ◽  
Rebecca M. Brock ◽  
Holly A. Morrison ◽  
Juselyn D. Tupik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Image Analysis ◽  
Lung Metastasis ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Computer Based ◽  
4T1 Breast Cancer

scholarly journals Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background

2008 ◽  
Vol 68 (15) ◽  
pp. 6251-6259 ◽  
Author(s):  
Michelle D. Martin ◽  
Kathy J. Carter ◽  
Sharon R. Jean-Philippe ◽  
Mayland Chang ◽  
Shahriar Mobashery ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Lung Metastasis ◽  
Genetic Background ◽  
Matrix Metalloproteinase 9 ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Stromal Matrix ◽  
Metalloproteinase 9
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