Effects of Thyroid State on the Formation and Early Morphological Development of Bergmann Glia in the Developing Rat Cerebellum

1980 ◽  
Vol 3 (4-6) ◽  
pp. 199-208 ◽  
Author(s):  
J. Clos ◽  
Christiane Legrand ◽  
J. Legrand
1977 ◽  
Vol 151 (2) ◽  
pp. 219-222 ◽  
Author(s):  
Eduardo Basc� ◽  
Ferenc Haj�s ◽  
Zolt�n F�l�p

1984 ◽  
Vol 62 (10) ◽  
pp. 1279-1283 ◽  
Author(s):  
Jean Ruel ◽  
Claire Chénard ◽  
Pierre Coulombe ◽  
Jean H. Dussault

In this study, we measured ornithine decarboxylase (ODC) activity as a potential parameter to evaluate the response of the developing rat brain to thyroid hormones. In cerebellum, neonatal hyperthyroidism (40 μg thyroxine/100 g body weight daily from birth) increased ODC activity at 2 and 5 days of age and then accelerated its developmental decline. Conversely, ODC activity was decreased in 2- and 5-day-old hypothyroid rats (propylthiouracil to the mother), but it was not significantly different from normal thereafter. No significant differences were observed in the forebrain following either treatment. In hypothyroid rat cerebellum, a single injection of triiodothyronine (T3, 100 μg/100 g 18 h before sacrifice) increased significantly ODC activity at all ages. A dose–response study showed that 0.5 μg T3/100 g is sufficient to obtain maximal stimulation. Finally, administration of antiserum against rat growth hormone had no significant effect on ODC response to T3. These results show that ODC is a useful marker of thyroid state and tissue response in the neonatal rat cerebellum.


1984 ◽  
Vol 15 (2) ◽  
pp. 298-301 ◽  
Author(s):  
N.J. Cook ◽  
M. Dontenwill ◽  
A. Meyer ◽  
G. Vincendon ◽  
J.P. Zanetta

1974 ◽  
Vol 16 (3) ◽  
pp. 205-211 ◽  
Author(s):  
SETSUYA FUJITA ◽  
TAKANORI HATTORI ◽  
MASARU FUKUDA ◽  
TADAHISA KITAMURA

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