ABSTRACT
The aqueous flare response (AFR) to MSH is induced in an increasing percentage of animals with increasing age. The great variability of the responses and the fact that local administration of MSH is not more efficient with lower doses than by subcutaneous injection indicate that the AFR is a complex result in which general factors play a part. The analysis of the variation of the responses has led to a procedure for testing the effect of different preparations.
Contribution of the conserved amino acids of the melanocortin-4 receptor in [Nle4,d-Phe7]-α-melanocyte-stimulating hormone binding and signaling. VOLUME 282 (2007) PAGES 21712-21719