A Case of Hereditary Protein S Deficiency Presenting with Cerebral Sinus Venous Thrombosis and Deep Vein Thrombosis at High Altitude

2008 ◽  
Vol 119 (3) ◽  
pp. 158-161 ◽  
Author(s):  
Velu Nair ◽  
A.K. Mohapatro ◽  
M. Sreedhar ◽  
I.K. Indrajeet ◽  
A.K. Tewari ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Deep Vein ◽  
Sinus Venous Thrombosis

scholarly journals Cerebral sinus venous thrombosis

2016 ◽  
Vol 5 (1) ◽  
pp. 177
Author(s):  
Sandhya Manorenj ◽  
Sudhaker Barla
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Venous Thrombosis ◽  
Protein S ◽  
Brain Parenchyma ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Background: Intracranial Sino venous occlusive disease is an infrequent condition and accounts only 0.5-1% of all strokes. Objective of the study was to know the prevalence, pattern and risk factors involved in patients of cerebral sinus venous thrombosis (CSVT).Methods: Hospital databases were searched retrospectively and patients diagnosed with CSVT from December 2014 to February 2016 were identified. Data on clinical presentation, risk factor, cerebral sinus involved, hospital stay and outcome were analyzed.Results: Fifteen patients (3.4%) were identified as CSVT out of a total acute stroke case of 430. Mean age of patients was 31 years and 11 (73.3%) were males. The presenting symptoms included headache (n=14), altered sensorium (n=1) and seizures (n=5); signs included hemi paresis (n=4), papilledema (n=8) and bilateral VI nerve palsy (n=3). Majority had aseptic CSVT (n=14), and one patient had septic CSVT associated with tuberculous meningitis (TBM). Radiological findings included brain parenchyma involvement (n=8), subdural hematoma (SDH) (n=1), subarachnoid haemorrhage (SAH) (n=1) and normal brain parenchyma (n=5). Multiple cerebral sinuses were involved in seven patients. Most common site of CSVT was observed in sigmoid sinus. Risk factors included hyperhomocystenemia (n=3), protein S deficiency (n=8), protein C deficiency (n=6) and antithrombin III deficiency (n=3) as primary hypercoagulable state. ANA positive was observed in one patient and four had history of alcohol use. All fifteen patients received low molecular weight heparin (LMWH) for 1 week along with bridging oral anticoagulant. None of the patients required intrasinus thrombolysis and decompression surgery. Average hospital stay was 9 days. All had modified Rankin scale (MRS) ≤ 2 at 6 months follow up.Conclusions: Prevalence of CSVT is higher than that reported from Asian studies. Younger age and male predominance was observed. Protein S deficiency was the major risk factor for CSVT.

Autoimmune Protein S Deficiency and Deep Vein Thrombosis after Chickenpox

1996 ◽  
Vol 75 (01) ◽  
pp. 212-213 ◽  
Author(s):  
Flora Peyvandi ◽  
Elena Faioni ◽  
Gian Alessandro Moroni ◽  
Alberto Rosti ◽  
Luigi Leo ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Deep Vein

scholarly journals One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis

2006 ◽  
Vol 81 (10) ◽  
pp. 787-797 ◽  
Author(s):  
Kazuhiro Mizukami ◽  
Toru Nakabayashi ◽  
Sumiyoshi Naitoh ◽  
Mika Takeda ◽  
Takashi Tarumi ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Protein S ◽  
Recurrent Mutation ◽  
Type I ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Deep Vein

Deep Vein Thrombosis and Pulmonary Embolism in a Child with Diabetic Ketoacidosis and Protein S Deficiency: A Case Report

2013 ◽  
Vol 79 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Triantafyllia Sdogou ◽  
Lydia Kossiva ◽  
Kostas Kakleas ◽  
Helen Platokouki ◽  
Theodora Tentolouri ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Case Report ◽  
Diabetic Ketoacidosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Deep Vein

scholarly journals Deep Vein Thrombosis in Protein S Deficiency

2010 ◽  
Vol 49 (177) ◽  
Author(s):  
A Joshi ◽  
J P Jaiswal
Keyword(s):  
Deep Vein Thrombosis ◽  
Vitamin K ◽  
Rare Condition ◽  
Protein S ◽  
Factor V ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
Hepatic Diseases ◽  
S Deficiency ◽  
Deep Vein

Protein S is a vitamin K-dependent anticoagulant protein. It functions as a cofactor of activated protein C to inactivate activated factor V (FVa) and activated factor VIII (FVIIIa). Its deficiency is a rare condition and can lead to deep vein thrombosis, pulmonary embolism or stroke. It is often treated with long-term anti-coagulant therapy. Protein S deficiency may be hereditary or acquired; the latter is usually due to hepatic diseases or a vitamin K deficiency. Protein S deficiency manifests as an autosomal dominant trait; manifestations of thrombosis are observed in both heterozygous and homozygous genetic deficiencies of protein S. This case report is of DVT due to Protein S deficiency in a 53 year old male. Venous Doppler was used to diagnose DVT and free Protein S level measured by ELISA. IVC filter was placed on the third day of admission. Keywords: antithrombotic, deep venous thrombosis, inferior venacaval filter, protein S.

Protein S Deficiency Presenting as Deep Vein Thrombosis

Angiology ◽  
2003 ◽  
Vol 54 (5) ◽  
pp. 605-608 ◽  
Author(s):  
Ashwinikumar A. Khandekar ◽  
Sunita D. Kumbhalkar ◽  
Harsha R. Salkar ◽  
Rakesh T. Parakkadavathu ◽  
Ramesh G. Salkar
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Deep Vein

Familial Protein S Deficiency Presenting as Deep Vein Thrombosis Occurring During Pregnancy

1990 ◽  
Vol 69 (6) ◽  
pp. 537-539 ◽  
Author(s):  
Armando D'angelo ◽  
Gilberto Mari ◽  
Patrizia Delia Valle ◽  
Alberto Marassi ◽  
Silvana Vigano' D'angelo
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Thrombosis ◽  
S Deficiency ◽  
Deep Vein
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