The Influence of Oxygen Free Radical Scavengers on the Reduction of Membrane-Bound Na+-K+-ATPase Activity Induced by Ischemia/Reperfusion Injury in the Canine Kidney

Nephron ◽  
1996 ◽  
Vol 72 (4) ◽  
pp. 637-643 ◽  
Author(s):  
Ichiro Kajiwara ◽  
Koji Kawamura ◽  
Yoshiharu Hiratsuka ◽  
Shigeo Takebayashi
Keyword(s):  
Free Radical ◽  
Atpase Activity ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Membrane Bound ◽  
Canine Kidney

scholarly journals Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 ◽  
Vol 86 (2) ◽  
pp. 262-272 ◽  
Author(s):  
James R. Stewart ◽  
William H. Blackwell ◽  
Stephen L. Crute ◽  
Victor Loughlin ◽  
Lazar J. Greenfield ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Surgically Induced

Experimental Evaluation of Oxygen Free Radical Scavengers in the Prevention of Reperfusion Injury to Skeletal Muscle

1989 ◽  
Vol 22 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Axel Mario Feller ◽  
Allan C. Roth ◽  
Robert C. Russell ◽  
Bernard Eagleton ◽  
Hans Suchy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Free Radical ◽  
Reperfusion Injury ◽  
Experimental Evaluation ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers

Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury

1991 ◽  
Vol 51 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Pedro Baron ◽  
Orlando Gomez-Marin ◽  
Camilo Casas ◽  
John Heil ◽  
Norman Will ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Oxygen Free Radical ◽  
Warm Ischemia ◽  
Free Radical Scavengers ◽  
Radical Scavengers

Inflammation and oxygen free radical formation during pulmonary ischemia-reperfusion injury

1992 ◽  
Vol 72 (2) ◽  
pp. 621-628 ◽  
Author(s):  
A. Hamvas ◽  
R. Palazzo ◽  
L. Kaiser ◽  
J. Cooper ◽  
T. Shuman ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Quantitative Imaging ◽  
Neutrophil Infiltration ◽  
Oxygen Free Radical ◽  
Severity Of Injury ◽  
Pulmonary Ischemia

In a companion study, we showed that 2 h of warm unilateral lung ischemia followed by reperfusion resulted in bilateral tissue injury, indicated by increases in extravascular density (EVD) and permeability, measured as the pulmonary transcapillary escape rate (PTCER) for radiolabeled transferrin. EVD and PTCER measurements were obtained with the quantitative imaging technique of positron emission tomography (PET). In the current study, we evaluated this increase in EVD histologically and correlated EVD and PTCER with measurements of oxidant-reactive sulfhydryls (RSH) in plasma as a marker of oxygen free radical (OFR) formation. Histologically edema, leukocyte infiltration, and hemorrhage were all present on the ischemic side, but only after reperfusion, whereas only neutrophil infiltration was observed on the nonischemic side. Histology scores correlated with EVD (r = 0.81) and PTCER (r = 0.75), but permeability was abnormal at times even in the absence of neutrophil infiltration. Plasma RSH concentration from the ischemic lung decreased significantly (P less than 0.05) during pulmonary ischemia (i.e., before reperfusion) and returned to baseline on reperfusion. The degree of RSH oxidation did not correlate with the severity of injury as measured by PET or histology. Thus pulmonary ischemia-reperfusion injury is characterized by inflammation, hemorrhage, edema, and OFR formation. Injury occurred after reperfusion, not after ischemia alone. In addition, injury to the contralateral nonischemic lung suggests a neutrophil-independent circulating mediator of injury.

Oxygen Free Radical Scavengers and Reperfusion Injury in Dog Lung Preserved in Cold Ischemia

1992 ◽  
Vol 40 (03) ◽  
pp. 144-147 ◽  
Author(s):  
A. Başoğlu ◽  
H. Koçak ◽  
M. Paç ◽  
M. Cerrahoğlu ◽  
N. Bakan ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Cold Ischemia

Experimental Evaluation of Oxygen-free Radical Scavengers in the Prevention of Reperfusion Injury to Skeletal Muscle

1988 ◽  
Vol 21 (5) ◽  
pp. 500
Author(s):  
Axel Mario Feller ◽  
Allan C. Roth ◽  
Robert C. Russell ◽  
Bernard Eagleton ◽  
Hans Suchy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Free Radical ◽  
Reperfusion Injury ◽  
Experimental Evaluation ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers

Oxygen free radical scavengers decrease reperfusion injury in lung transplantation

1990 ◽  
Vol 50 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Frank C. Detterbeck ◽  
Blair A. Keagy ◽  
Douglas E. Paull ◽  
Benson R. Wilcox
Keyword(s):  
Free Radical ◽  
Lung Transplantation ◽  
Reperfusion Injury ◽  
Oxygen Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers
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