In vitro-in vivo Correlation in Anticancer Drug Sensitivity Test Using AUC-Based Concentrations and Collagen Gel Droplet-Embedded Culture

Oncology ◽  
1996 ◽  
Vol 53 (3) ◽  
pp. 250-257 ◽  
Author(s):  
Makoto Inaba ◽  
Tazuko Tashiro ◽  
Shigeo Sato ◽  
Yasuyuki Ohnishi ◽  
Keizo Tanisaka ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Sensitivity ◽  
Collagen Gel ◽  
Sensitivity Test ◽  
Drug Sensitivity Test

scholarly journals Stratified phase II trial to establish the usefulness of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) for advanced gastric cancer

2013 ◽  
Vol 17 (4) ◽  
pp. 630-637 ◽  
Author(s):  
Hiroyuki Naitoh ◽  
Hiroshi Yamamoto ◽  
Satoshi Murata ◽  
Hisayuki Kobayashi ◽  
Katsunori Inoue ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Phase Ii ◽  
Drug Sensitivity ◽  
Phase Ii Trial ◽  
Collagen Gel ◽  
Sensitivity Test ◽  
Drug Sensitivity Test

O-45 Drug sensitivity test (in vitro growth assay) of gefitinib (Iressa, ZD1839) for primary lung cancer

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S16
Author(s):  
Motoshi Takao ◽  
Kentaro Inoue ◽  
Fumiaki Watanabe ◽  
Tomohito Tarukawa ◽  
Masanori Kaneda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Sensitivity ◽  
Primary Lung Cancer ◽  
Sensitivity Test ◽  
In Vitro Growth ◽  
Drug Sensitivity Test ◽  
Growth Assay

The Collagen Gel Droplet–embedded Culture Drug Sensitivity Test in Relapsed Hepatoblastoma

2017 ◽  
Vol 39 (5) ◽  
pp. 395-401 ◽  
Author(s):  
Hiroaki Goto ◽  
Norihiko Kitagawa ◽  
Hironobu Sekiguchi ◽  
Yohei Miyagi ◽  
Dai Keino ◽  
...  
Keyword(s):  
Drug Sensitivity ◽  
Collagen Gel ◽  
Sensitivity Test ◽  
Drug Sensitivity Test

Study on the effect of superparamagnetic γ-Fe2O3 combined with carmustine on cervical cancer

2020 ◽  
Vol 10 (8) ◽  
pp. 1213-1217
Author(s):  
Jinghua Xiao ◽  
Yani Li ◽  
Yanxia Wang ◽  
Xinru Wang ◽  
Wanwan Zhang ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Drug Sensitivity ◽  
Combined Treatment ◽  
Scientific Basis ◽  
Carcinoma Cells ◽  
Sensitivity Test ◽  
Control Group ◽  
Multidrug Resistance Gene ◽  
Drug Sensitivity Test

This study aims to investigate the killing effect of γ-Fe2O3 combined with carmustine on cervical carcinoma cells, as well as the mechanism of drug resistance of this combined treatment. RT-PCR was used to detect the expression of Multidrug Resistance Gene (MDR-l) gene in all the samples. Results showed that the combination of γ-Fe2O3 and carmustine drugs was significantly better than the control group (P < 0.05), and the tumor showed different degrees of tolerance in combination with the drug. The results of an in vitro drug sensitivity test were consistent with those of mRNA expression of MDR-l gene (P < 0.04). The combination of superparamagnetic γ-Fe2O3 and carmustine derivatives has a better therapeutic effect on cervical carcinoma than either treatment alone. The drug sensitivity test and MDR-l mRNA detection in vitro can improve the accuracy and predictability of cervical carcinoma chemotherapy, providing a scientific basis for individual tumor chemotherapy.

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