scholarly journals Diffusion Tensor Imaging in a Case of Pontine Bleeding Showing Hypertrophic Olivary Degeneration and Cerebellar Ataxia

2018 ◽  
Vol 10 (3) ◽  
pp. 297-301 ◽  
Author(s):  
Fumihito Yoshii ◽  
Yuichi Tomori ◽  
Teruo Mori
Keyword(s):  
Diffusion Tensor Imaging ◽  
Cerebellar Ataxia ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
Superior Cerebellar Peduncle ◽  
Ataxic Gait ◽  
Hypertrophic Olivary Degeneration ◽  
Central Tegmental Tract ◽  
Cerebellar Peduncle ◽  
Inferior Olivary

We present diffusion tensor tractography (DTT) findings in a case of hypertrophic olivary degeneration (HOD) and cerebellar ataxia. A 56-year-old man presented with abnormal ataxic gait and dysarthria. MRI 5 months after onset showed chronic pontine hematoma and enlarged bilateral inferior olivary nuclei. DTT showed decreased volume of the bilateral central tegmental tract, in accordance with the conventional hypothesis that HOD is associated with neurologic insult to the Guillain-Mollaret triangle. The patient’s cerebellar ataxia was speculated to be due to decreased decussating fibers of the superior cerebellar peduncle, and this was confirmed by DTT.

scholarly journals The Dentato-Rubro-Olivary Tract: Clinical Dimension of This Anatomical Pathway

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Fadil Khoyratty ◽  
Thomas Wilson
Keyword(s):  
Red Nucleus ◽  
Inferior Olivary Nucleus ◽  
Superior Cerebellar Peduncle ◽  
Palatal Tremor ◽  
History Of ◽  
Brachium Conjunctivum ◽  
Central Tegmental Tract ◽  
Cerebellar Peduncle ◽  
Inferior Olivary ◽  
Olivary Nucleus

Symptomatic palatal tremor is potentially the result of a lesion in the triangle of Guillain-Mollaret (1931) and is associated with hypertrophic olivary degeneration (HOD) which has characteristic MR findings. The triangle is defined by dentate efferents ascending through the superior cerebellar peduncle and crossing in the decussation of the brachium conjunctivum inferior to the red nucleus, to finaliy reach the inferior olivary nucleus (ION) via the central tegmental tract. The triangle is completed by ION decussating efferents terminating on the original dentate nucleus via the inferior cerebellar peduncle. We can demonstrate the anatomy of this anatomical triangle using a clinical case of palatal tremor presenting with bilateral subjective pulsatile tinnitus along with the pathognomonic MR findings previously described. The hyperintense T2 signal in these patients may be permanent, but the hypertrophied olive normally regresses after 4 years. The temporal relationship between the evolution of the histopathology and the development of the palatal tremor remains unknown as does the natural history of the tremor. Botox injection at the level of tensor and levator veli palatini insertion have been used to treat patients with disabling tremor synchronous tinnitus. A lesion involving the triangle can have a quite varied clinical expression.

Diffusion tensor imaging of the superior cerebellar peduncle identifies patients with posterior fossa syndrome

2013 ◽  
Vol 29 (11) ◽  
pp. 2071-2077 ◽  
Author(s):  
Jeffrey G. Ojemann ◽  
Savannah C. Partridge ◽  
Andrew V. Poliakov ◽  
Toba N. Niazi ◽  
Dennis W. Shaw ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Posterior Fossa ◽  
Diffusion Tensor ◽  
Superior Cerebellar Peduncle ◽  
Posterior Fossa Syndrome ◽  
Cerebellar Peduncle

scholarly journals Diffusion tensor imaging of the superior cerebellar peduncle

2013 ◽  
Vol 29 (12) ◽  
pp. 2143-2143
Author(s):  
Bilal Battal ◽  
Salih Hamcan ◽  
Veysel Akgun
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Superior Cerebellar Peduncle ◽  
Cerebellar Peduncle

scholarly journals Further diffusion tensor imaging contribution in horizontal gaze palsy and progressive scoliosis

2009 ◽  
Vol 67 (4) ◽  
pp. 1054-1056 ◽  
Author(s):  
Maria Conceptión García Otaduy ◽  
Claudia da Costa Leite ◽  
Lídia Mayumi Nagae ◽  
Marco da Cunha Pinho ◽  
Clarissa Bueno ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Clinical Diagnosis ◽  
Diffusion Tensor ◽  
Medial Lemniscus ◽  
Surrogate Markers ◽  
Superior Cerebellar Peduncle ◽  
Progressive Scoliosis ◽  
Horizontal Gaze ◽  
Cerebellar Peduncle ◽  
Gaze Palsy

In two siblings with clinical diagnosis of horizontal gaze palsy associated with progressive scoliosis (HGPPS) we could demonstrate by diffusion tensor imaging: (1) An anterior displacement of the transverse pontine fibers; (2) Posterior clumping of the corticospinal, medial lemniscus and central tegmental tracts and of the medial and dorsal longitudinal fasciculi complex; (3) Absent decussation of superior cerebellar peduncle. Those findings can contribute as surrogate markers for the diagnosis.

Hypertrophic olivary degeneration in a child following midbrain tumor resection: longitudinal diffusion tensor imaging studies

2014 ◽  
Vol 13 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Gunes Orman ◽  
Thangamadhan Bosemani ◽  
George I. Jallo ◽  
Thierry A. G. M. Huisman ◽  
Andrea Poretti
Keyword(s):  
Diffusion Tensor Imaging ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Red Nucleus ◽  
Tumor Resection ◽  
Inferior Olivary Nucleus ◽  
Hypertrophic Olivary Degeneration ◽  
Inferior Olivary ◽  
Olivary Nucleus ◽  
Over Time

Hypertrophic olivary degeneration (HOD) is a dynamic process caused by disruptive lesions affecting components of the Guillain-Mollaret triangle (GMT). The authors applied diffusion tensor imaging (DTI) to investigate longitudinal changes of the GMT components in a child with HOD after neurosurgery for a midbrain tumor. Diffusion tensor imaging data were acquired on a 1.5-T MRI scanner using a balanced pair of diffusion gradients along 20 noncollinear directions 1 day and 3, 6, and 9 months after surgery. Measurements from regions of interest (ROIs) were sampled in the affected inferior olivary nucleus, ipsilateral red nucleus, and contralateral superior and inferior cerebellar peduncles and dentate nucleus. For each ROI, fractional anisotropy and the mean, axial, and radial diffusivities were calculated. In the affected inferior olivary nucleus, the authors found a decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivities 3 months after surgery, while 3 months later fractional anisotropy increased and diffusivities decreased. For all other GMT components, changes in DTI scalars were less pronounced, and fractional anisotropy mildly decreased over time. A detailed analysis of longitudinal DTI scalars in the various GMT components may shed light on a better understanding of the dynamic complex histopathological processes occurring in pediatric HOD over time.

scholarly journals White matter differences between essential tremor and Parkinson disease

Neurology ◽  
2018 ◽  
Vol 92 (1) ◽  
pp. e30-e39 ◽  
Author(s):  
Meher R. Juttukonda ◽  
Giulia Franco ◽  
Dario J. Englot ◽  
Ya-Chen Lin ◽  
Kalen J. Petersen ◽  
...  
Keyword(s):  
White Matter ◽  
Parkinson Disease ◽  
Essential Tremor ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Superior Cerebellar Peduncle ◽  
Radial Diffusivity ◽  
Cerebellar Peduncles ◽  
Cerebellar Peduncle

ObjectiveTo assess white matter integrity in patients with essential tremor (ET) and Parkinson disease (PD) with moderate to severe motor impairment.MethodsSedated participants with ET (n = 57) or PD (n = 99) underwent diffusion tensor imaging (DTI) and fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values were computed. White matter tracts were defined using 3 well-described atlases. To determine candidate white matter regions that differ between ET and PD groups, a bootstrapping analysis was applied using the least absolute shrinkage and selection operator. Linear regression was applied to assess magnitude and direction of differences in DTI metrics between ET and PD populations in the candidate regions.ResultsFractional anisotropy values that differentiate ET from PD localize primarily to thalamic and visual-related pathways, while diffusivity differences localized to the cerebellar peduncles. Patients with ET exhibited lower fractional anisotropy values than patients with PD in the lateral geniculate body (p < 0.01), sagittal stratum (p = 0.01), forceps major (p = 0.02), pontine crossing tract (p = 0.03), and retrolenticular internal capsule (p = 0.04). Patients with ET exhibited greater radial diffusivity values than patients with PD in the superior cerebellar peduncle (p < 0.01), middle cerebellar peduncle (p = 0.05), and inferior cerebellar peduncle (p = 0.05).ConclusionsRegionally, distinctive white matter microstructural values in patients with ET localize to the cerebellar peduncles and thalamo-cortical visual pathways. These findings complement recent functional imaging studies in ET but also extend our understanding of putative physiologic features that account for distinctions between ET and PD.

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