scholarly journals Regressed Seminoma with Metastases to the Jejunum and Retroperitoneum

2021 ◽  
pp. 418-423
Author(s):  
Nozomi Kashu ◽  
Shoji Oura ◽  
Naoki Kataoka ◽  
Shinichiro Makimoto
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Residual Tumor ◽  
Final Diagnosis ◽  
Undifferentiated Carcinoma ◽  
Pathological Examination ◽  
Left Testis ◽  
Regional Lymph Nodes ◽  
Poorly Differentiated

A 66-year-old man with vomiting and weight loss was referred to our hospital. Abdominal computed tomography showed small bowel obstruction caused by a presumed small intestinal tumor. Single-balloon endoscopy showed an ulcerated tumor and marked stenosis of the jejunum. Immunohistochemical staining suggested the tumor to be poorly differentiated or undifferentiated carcinoma. The patient underwent open surgical resection of the jejunal tumor and regional lymph nodes both to improve the quality of life of the patient and to possibly get a cure of the presumed jejunal carcinoma. Pathological examination of the excised tumor and lymph nodes including para-aortic lymph nodes showed large-sized tumor cells and massive lymphocyte infiltrates. Immunostaining showed the tumor cells to be OCT3/4, AE1/AE3, CD117, and D2-40 positive, leading to the diagnosis of metastatic seminoma. With the preoperative diagnosis of a presumed burned-out tumor of the testis, the patient underwent left high orchiectomy. Pathological examination of the left testis showed marked scar tissue, no teratoma elements, and no residual tumor cells. Under the final diagnosis of regressed seminoma, the patient has received combination chemotherapy using bleomycin, etoposide, and cisplatin as adjuvant chemotherapy. Surgical oncologists should take regressed seminoma into their differential diagnosis when the biopsy specimens of the presumed intestinal malignancy show poorly differentiated or undifferentiated atypical cells with massive lymphocyte infiltrates, especially in postpubertal men. Confirmation of a malignant noninvasive component should be another important clue to the appropriate differential diagnosis when choosing between metastatic seminoma and poorly differentiated or undifferentiated intestinal primary malignancies.

Cutaneous Lymphosarcoma of Helper/Inducer T-Cell Origin in a Calf

1987 ◽  
Vol 24 (6) ◽  
pp. 504-508 ◽  
Author(s):  
R. D. Zwahlen ◽  
A. Tontis ◽  
A. Schneider
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Mycosis Fungoides ◽  
Lymphoproliferative Disease ◽  
T Helper ◽  
Regional Lymph Nodes ◽  
Skin Nodules ◽  
Neoplastic Lymphocytes ◽  
Suggested Classification

A calf with a lymphoproliferative disease resembling human mycosis fungoides, had multiple, ulcerated skin nodules with enlarged regional lymph nodes. Tumor cells were 10–15 μm in diameter and had round to oval nuclei without indentations. Mitoses were regularly present. Pautrier's microabscesses were in the epidermis, and T-cell areas of regional lymph nodes were infiltrated by neoplastic cells. Demonstration of the T-helper/inducer origin of neoplastic lymphocytes suggested classification in analogy with human mycosis fungoides.

scholarly journals Rare incidence of non-secretory myeloma with talaromycosis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haiting Qin ◽  
Ye Qiu ◽  
Yanmei Huang ◽  
Mianluan Pan ◽  
Dong Lan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Clinical Symptoms ◽  
Subcutaneous Tissue ◽  
Community Acquired Pneumonia ◽  
Pathological Examination ◽  
Subcutaneous Nodules ◽  
Lung Lymph

Abstract Background Talaromyces marneffei (TM) primarily infects patients with co-morbidities that cause immunodeficiency, but non-secretory myeloma (NSMM) is rare. TSM and NSMM are associated with fever, osteolysis, and swollen lymph nodes, thereby making it difficult for clinicians to make differential diagnosis. In this case, we describe TM infection coexisting with NSMM. Case presentation We retrospectively reviewed the case of a male (without human immunodeficiency virus infection) with fever, thoracalgia, swollen lymph nodes, and subcutaneous nodules who presented to the First Affiliated Hospital of Guangxi Medical University in February 2014. Chest computed tomography revealed patchy infiltration and positron emission tomography/computed tomography showed increased metabolic activity in the lower-right lung, lymph nodes, left ninth rib, and right ilium. Pathological examination of the lung, lymph nodes, subcutaneous nodules, and bone marrow showed no malignancy, he was diagnosed with community-acquired pneumonia. His clinical symptoms did not improve after anti-bacterial, anti-Mycobacterium tuberculosis, and anti-non-M. tuberculosis treatment. Later, etiological culture and pathological examination of the subcutaneous nodule proved TM infection, and the patient was re-diagnosed with disseminated TSM, which involved the lungs, lymph nodes, skin, bone, and subcutaneous tissue. After antifungal treatment, the patient showed significant improvement, except for the pain in his bones. Imaging showed aggravated osteolysis, and bone marrow biopsy and immunohistochemistry indicated NSMM. Thus, we conclusively diagnosed the case as NSMM with TSM (involving the lungs, lymph nodes, skin, and subcutaneous tissue). His condition improved after chemotherapy, and he was symptom-free for 7 years. Conclusion TM infection is rare in individual with NSMM. Since they have clinical manifestation in common, easily causing misdiagnosis and missed diagnosis, multiple pathological examinations and tissue cultures are essential to provide a differential diagnosis.

Giant chronic foot ulcer with damage to the calcaneus and lower leg, simulating a malignant tumor

2021 ◽  
Vol 87 (1) ◽  
pp. 63-65
Author(s):  
V.L. Kovalenko ◽  
◽  
A.V. Stepochkin ◽  
A.A. Kuznetsov ◽  
◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Malignant Tumor ◽  
Foot Ulcer ◽  
Lower Leg ◽  
Rare Form ◽  
Regional Lymph Nodes

The article presents the observation of a rare form of chronic foot ulcer with damage to the surrounding tissues and regional lymph nodes, proceeding as a malignant tumor. The article demonstrates the complexity of the clinical and morphological differential diagnosis of this form of the disease.

Sporothrix brasiliensis meningitis in an immunocompetent patient

2021 ◽  
pp. practneurol-2020-002915
Author(s):  
Marco A Lima ◽  
Renan Vallier ◽  
Marcos M Silva
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Subcutaneous Tissue ◽  
Rare Condition ◽  
Immunocompetent Patient ◽  
Diagnosis And Treatment ◽  
Chronic Meningitis ◽  
Regional Lymph Nodes ◽  
Sporothrix Brasiliensis ◽  
Immunosuppressed Patients

Sporothrix brasiliensis usually causes infection limited to the skin, subcutaneous tissue and regional lymph nodes. Contamination occurs through inhalation or accidental inoculation from animal scratches and bites. Meningitis is rare and mostly occurs in immunosuppressed patients. Here, we describe an immunocompetent person who developed chronic meningitis and discuss the diagnosis, differential diagnosis and treatment of this rare condition.

scholarly journals OC-0159: Disseminated tumor cells as factor of benefit of regional lymph nodes irradiation in breast cancer

2018 ◽  
Vol 127 ◽  
pp. S81
Author(s):  
F. Mignot ◽  
F.C. Bidard ◽  
S. Dureau ◽  
A. Fourquet ◽  
F. Berger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Disseminated Tumor Cells ◽  
Regional Lymph Nodes

High prevalence of isolated tumor cells (ITC) in regional lymph nodes from PN0 colorectal cancer

2006 ◽  
Vol 38 ◽  
pp. S107
Author(s):  
C. Mescoli ◽  
L. Giacomelli ◽  
E. Portolan ◽  
V. Russo ◽  
G. Ingravallo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Isolated Tumor Cells ◽  
Regional Lymph Nodes ◽  
High Prevalence

scholarly journals FEATURES OF DEFEATS OF SENTINEL LYMPH NODES AT PRIMARY MELANOMA OF SKIN

2019 ◽  
Vol 26 (1) ◽  
pp. 54-60
Author(s):  
Vladimir A. Ershov ◽  
Ada V. Anisimova ◽  
Sergei M. Vashkurov ◽  
Svetlana P. Vorob’eva ◽  
Natalia D. Shchelkova ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Primary Melanoma ◽  
Sentinel Lymph Nodes ◽  
Skin Melanoma ◽  
Isolated Cells ◽  
Regional Lymph Nodes ◽  
Secondary Tumor

Introduction. Each tenth tumor of skin is melanoma. Presence of tumor cells in sentinel lymph node influenced the medical tactics.The objective of the research was to study the metastasis of skin melanoma into the clinically negative regional lymph nodes.Material and methods. Histological, immunohistochemical, cytological and immunocytochemical methods were used to study biopsies of regional lymph nodes in 60 patients with skin melanoma.Results. 5 % of patients were diagnosed with melanoma in situ, 15 % – Т1, 28.3 % – Т2, 23.3 % – Т3, 28.3 % – Т4. At outflow of the lymph through 1 collector, the metastases in sentinel lymph node (SLN) was defined in 51 %, through 2 collectors – in 81.8 % of cases. Tumor cells damaged single lymph node in 35.3 % of cases, two and more lymph nodes in 64.7 % of cases. Metastases in SLN with formation of secondary tumor at the T1 melanoma were observed at 11.1 %, T2 – 5.9 %, T3 – 21.4 %, T4 – 47.1 % of studies. Clusters of cells or isolated cells of melanoma in SLN at Т1 were noted in 22.2 %, at Т2 – in 41.2 %, at Т3 – in 42.9 %, at Т4 – in 35.3 % of cases. At outflow of lymph through 1 collector, metastasises of melanoma in non-sentinel lymph nodes (NSLN) were revealed in 24 %, through 2 collectors – in 44.4 % of cases. Secondary changes of NSLN were noted in 16.7 % of cases of defeat of single SLN, in 31.8 % of cases of defeat of two and more SLN. Metastases of melanoma were revealed in 69.2 % of cases of formation of secondary tumor and in 4.8 % of cases of presence of clusters in SLN in removed NSLN.Conclusion. At increase of Тmelanoma of the skin, the quantity of sentinel lymph nodes with reactive changes decreased, and their number with metastases increased. Metastatic defeat of sentinel lymph nodes at outflow of lymph through 2 lymph collectors in two and more SLN and NSLN exceeded the defeat of SLN at outflow of lymph through 1 lymph collector in single lymph nodes. The use of immunocytochemical method of research allowed to expand pathomorphological verification of metastatic defeat of sentinel lymph nodes by 66.7%.

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