scholarly journals Tofacitinib: An Option for Acute Severe Ulcerative Colitis?

2021 ◽  
pp. 1-3
Author(s):  
Sara Santos ◽  
Verónica Gamelas ◽  
Rita Saraiva ◽  
Guilherme Simões ◽  
Joana Saiote ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Improvement ◽  
Rescue Therapy ◽  
New Drugs ◽  
Multiple Drug ◽  
Disease Course ◽  
Efficacy And Safety ◽  
Severe Ulcerative Colitis ◽  
Rapid Absorption

Tofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for new drugs and data on their efficacy and safety. We describe 2 cases of acute episodes in which tofacitinib was used as a rescue therapy.

Long-term Efficacy and Safety of Cyclosporine as a Rescue Therapy in Acute, Steroid-refractory Severe Ulcerative Colitis

2011 ◽  
Vol 45 (4) ◽  
pp. 380-381 ◽  
Author(s):  
Tamás Molnár ◽  
Klaudia Farkas ◽  
Tibor Nyári ◽  
Zoltán Szepes ◽  
Ferenc Nagy ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Efficacy And Safety ◽  
Severe Ulcerative Colitis ◽  
Term Efficacy ◽  
Steroid Refractory

scholarly journals Long-term outcomes of acute severe ulcerative colitis in the rescue therapy era: A multicentre cohort study

2020 ◽  
pp. 205064062097740
Author(s):  
Stefano Festa ◽  
Maria L Scribano ◽  
Daniela Pugliese ◽  
Cristina Bezzio ◽  
Mariabeatrice Principi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Tumour Necrosis ◽  
Rescue Therapy ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Severe Ulcerative Colitis ◽  
Factor Alpha ◽  
Necrosis Factor

Background The long-term course of ulcerative colitis after a severe attack is poorly understood. Second-line rescue therapy with cyclosporine or infliximab is effective for reducing short-term colectomy but the impact in the long-term is controversial. Objective The purpose of this study was to evaluate the long-term course of acute severe ulcerative colitis patients who avoid early colectomy either because of response to steroids or rescue therapy. Methods This was a multicentre retrospective cohort study of adult patients with acute severe ulcerative colitis admitted to Italian inflammatory bowel disease referral centres from 2005–2017. All patients received intravenous steroids, and those who did not respond received either rescue therapy or colectomy. For patients who avoided early colectomy (within three months from the index attack), we recorded the date of colectomy, last follow-up visit or death. The primary end-point was long-term colectomy rate in patients avoiding early colectomy. Results From the included 372 patients with acute severe ulcerative colitis, 337 (90.6%) avoided early colectomy. From those, 60.5% were responsive to steroids and 39.5% to the rescue therapy. Median follow-up was 44 months (interquartile range, 21–85). Colectomy-free survival probability was 93.5%, 81.5% and 79.4% at one, three and five years, respectively. Colectomy risk was higher among rescue therapy users than in steroid-responders (log-rank test, p = 0.02). At multivariate analysis response to steroids was independently associated with a lower risk of long-term colectomy (adjusted odds ratio = 0.5; 95% confidence interval, 0.2–0.8), while previous exposure to anti-tumour necrosis factor alpha agents was associated with an increased risk (adjusted odds ratio = 3.0; 95% confidence interval, 1.5–5.7). Approximately 50% of patients required additional therapy or new hospitalization within five years due to a recurrent flare. Death occurred in three patients (0.9%). Conclusions Patients with acute severe ulcerative colitis avoiding early colectomy are at risk of long-term colectomy, especially if previously exposed to anti-tumour necrosis factor alpha agents or if rescue therapy during the acute attack was required because of steroid refractoriness.

Intensified Infliximab Rescue Therapy for Acute Severe Ulcerative Colitis does not Improve Long Term Colectomy-Free Survival

2017 ◽  
Vol 152 (5) ◽  
pp. S399 ◽  
Author(s):  
Alex Al Khoury ◽  
Che-yung Chao ◽  
Talat Bessissow ◽  
Jonathan Wyse ◽  
Achuthan Aruljothy
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Free Survival ◽  
Severe Ulcerative Colitis

scholarly journals P495 Intensified infliximab rescue therapy for acute severe ulcerative colitis does not improve long term colectomy-free survival

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S330-S331 ◽  
Author(s):  
A. Al Khoury ◽  
C.-y. Chao ◽  
A. Aruljothy ◽  
J. Wyse ◽  
T. Bessissow
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Free Survival ◽  
Severe Ulcerative Colitis
Sign in / Sign up

Export Citation Format

Share Document