scholarly journals The First Report on Incidence of Nasopharyngeal Carcinoma in Sabah, Borneo

ORL ◽  
2021 ◽  
pp. 1-5
Author(s):  
Eugene Hung Chih Wong ◽  
Heng Yao Tan ◽  
Tracey May Dompok ◽  
Luqman Afiq Mohamad Ishak ◽  
Siow Ping Loong
Keyword(s):  
Risk Factors ◽  
Nasopharyngeal Carcinoma ◽  
Ethnic Groups ◽  
The State ◽  
Age At Diagnosis ◽  
Published Data ◽  
Female Ratio ◽  
First Report ◽  
Common Cancer ◽  
Male To Female

<b><i>Background:</i></b> Nasopharyngeal carcinoma (NPC) is the fourth common cancer in Malaysia. A few studies have looked into the incidence of NPC in Malaysia in general, but there has been no published data on its incidence in Sabah specifically, where NPC is very common among the population. The aim of this study is to present the first report on the incidence of NPC in the state of Sabah, Borneo. <b><i>Methods:</i></b> Data of all patients diagnosed with NPC over a 5-year period from January 2015 to December 2019 inclusive were collected from the NPC registry of 3 main hospitals in Sabah. Age-standardized rates (ASRs) for different genders, ethnicities, and districts of origin were calculated. <b><i>Results:</i></b> 215 NPC patients were identified with a mean age at diagnosis of 49 (range 9–82). The ASR of NPC was 7.9/100,000 where the average age-adjusted male-to-female ratio was 2.4. The highest ASR was found in Dusun ethnicity in both male (3.19/100,000) and female (1.69/100,000) individuals, followed by Chinese (both genders), and Kadazan (for male individuals) and Bajau (for female individuals). The highest ASR was found in patients originating from Sandakan, Kota Kinabalu, Keningau, and Tawau. <b><i>Conclusion:</i></b> This is the first report on the incidence of NPC in Sabah, Borneo. The data suggest high ASRs among the population, especially in male Dusun and Chinese ethnic groups. Further research looking into NPC in this state, especially on risk factors and ways to improve diagnosis and prevention among the population, is recommended.

scholarly journals The Incidence of Nasopharyngeal Carcinoma in Pahang State of Malaysia from 2012 to 2017

2021 ◽  
Vol 28 (1) ◽  
pp. 66-74
Author(s):  
Azmir Ahmad ◽  
Wardah Mohd Yassin ◽  
Nor Azlina A Rahman ◽  
Wan Ishlah Leman ◽  
Luqman Rosla ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Newly Diagnosed ◽  
Crude Incidence Rate ◽  
Female Ratio ◽  
Crude Incidence ◽  
Common Cancer ◽  
Increasing Trend ◽  
Referral Hospitals ◽  
The Mean ◽  
Male To Female

Background: Nasopharyngeal carcinoma (NPC) is the fifth most common cancer among Malaysians. While several studies have reported the trend of NPC in other states in Malaysia, no studies have reported the trend of NPC in Pahang state. This study was designed to report the number and distribution of newly diagnosed NPC cases in Pahang. Methods: NPC cases that were diagnosed between 2012 and 2017 in two referral hospitals in Pahang were traced. The crude incidence rate (CR) and age-standardised rate (ASR) were calculated to investigate the NPC incidence. Results: There were 143 new cases of NPC reported from the two hospitals. The mean age at diagnosis was 52.0 ± 13.7 years old. The majority of cases involved males (74.1%) with a male to female ratio of 2.9:1. Chinese males were found to have the highest incidence with a mean ASR of 4.7 per 100,000 population. Overall, the mean ASR for Pahang was 2.4 per 100,000 population for males and 0.9 per 100,000 population for females. Conclusion: The total number of NPC cases reveals an increasing trend from 2012 to 2014 and then a slightly decreasing trend from 2015 to 2017. The incidence of NPC in Pahang was intermediate in males and low in females.

Thyrotoxic periodic paralysis

2011 ◽  
pp. 452-454
Author(s):  
Annie W.C. Kung
Keyword(s):  
African American ◽  
American Indian ◽  
Ethnic Groups ◽  
Japanese Population ◽  
Chinese Population ◽  
Periodic Paralysis ◽  
Thyrotoxic Periodic Paralysis ◽  
Female Ratio ◽  
Asian Populations ◽  
Male To Female

The association of thyrotoxicosis and periodic paralysis was first described in 1902 in a white patient. However, it soon became evident that thyrotoxic periodic paralysis (TPP) affects mainly Asian populations, in particular Chinese and Japanese, although isolated cases have also been reported in other ethnic groups such as white, Hispanic, African-American, and American Indian populations. The incidence of TPP in non-Asian thyrotoxic patients is around 0.1%, whereas in Chinese and Japanese thyrotoxic patients, TPP affects 1.8% and 1.9%, respectively (1–3). Despite a higher incidence of thyrotoxicosis in women, TPP affects mainly men, with a male to female ratio ranging from 17:1 to 70:1, according to different series. In the Chinese population, TPP affects 13% of male and 0.17% of female thyrotoxic patients. In the Japanese population, TPP was reported to occur in 8.2% of male and 0.4% of female thyrotoxic patients in the 1970s, but in 1991 the reported incidence had decreased to 4.3% and 0.04%, respectively (4).

Asthma in the Critically Ill Patient

2019 ◽  
pp. 150-156
Author(s):  
Jonathan J. Danaraj ◽  
Augustine S. Lee
Keyword(s):  
United States ◽  
Risk Factors ◽  
Immunoglobulin E ◽  
Age Distribution ◽  
The United States ◽  
Critically Ill Patient ◽  
Common Condition ◽  
Female Ratio ◽  
Genetic And Environmental Factors ◽  
Male To Female

Asthma is a common condition that affects an estimated 24 million children and adults in the United States (prevalence, 8%-10%). Globally, over 300 million people are affected and the number is expected to increase. The age distribution is bimodal, but in most patients, asthma is diagnosed before age 18 years (male to female ratio, 2:1 in children; 1:1 in adults). Susceptibility to asthma is multifactorial with both genetic and environmental factors. The strongest risk factor is atopy, a sensitivity to the development of immunoglobulin E (IgE) to specific allergens. A person with atopy is 3- to 4-fold more likely to have asthma than a person without atopy. Other risk factors include birth weight, prematurity, tobacco use (including secondary exposure), and obesity.

Risk factors of occurrence of Toxoplasma gondii among horses in the state of Alagoas, Brazil

2015 ◽  
Vol 60 (4) ◽  
Author(s):  
Sandra R. Fonseca de Araújo Valença ◽  
Rômulo M. Barreto Valença ◽  
José Wilton Pinheiro Júnior ◽  
Pedro P. Feitosa de Albuquerque ◽  
Orestes L. Souza Neto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Immunofluorescence Assay ◽  
The State ◽  
Cutoff Point ◽  
First Report ◽  
Associated Risk Factors ◽  
And Storage

AbstractThe aim of the present study was to investigate the occurrence of Toxoplasma gondii among horses and its associated risk factors in Alagoas, Brazil. In total, 440 samples from 36 properties in 23 districts of the state of Alagoas were studied, covering the Leste, Agreste and Sertão mesoregions. Risk factors were evaluated through the application of an investigative questionnaire that focused on the productive, reproductive and sanitary management of herds. T. gondii infection were assayed using the immunofluorescence assay (IFA) with a cutoff point of 64; 14.4% (95% CI: 11.0%-17.8%) of - horses were seropositive. A significant association was determined between anti-T. gondii antibody presence and the consumption and storage of hay (OR = 2.08 / 95% CI: 1.20-3.62). This is the first report of T. gondii infection among horses in the state of Alagoas, Brazil.

Incidence and pattern of leukemia in Bhutanese population: a retrospective analysis of eight years (January 2008 to December 2015)

2016 ◽  
Vol 2 (2) ◽  
pp. 6-9
Author(s):  
Kuenzang Dorji ◽  
Krishna Prasad Sharma ◽  
Rinzin Jamtsho ◽  
Puja Devi Samal ◽  
Dorji Wangchuk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Incidence Rate ◽  
Blood Cells ◽  
Statistical Significance ◽  
Descriptive Statistics ◽  
Haematological Malignancies ◽  
Female Ratio ◽  
Male To Female ◽  
National Referral Hospital

Introduction: The burden of haematological malignancies in developing countries is on the rise. This burden may be further aggravated in Bhutan due to the aging population and rapid modernization of the nation. Despite this, there is a paucity of information about the incidence and pattern of leukemia in the Bhutanese population. In this retrospective study, we aim to investigate the incidence and pattern of leukemia in Bhutan using a database of leukemia diagnosed at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan from January 2008 to December 2015. Methods: The diagnoses and classification of leukemias were based on the morphology of blood cells on peripheral blood and bone marrow smears. The data was analyzed with descriptive statistics. The age-standardized incidence rate per 100,000 populations and its 95% confidence interval was calculated to assess the statistical significance. Results: In total 118 patients were diagnosed with leukemia over the period of eight years. Leukemia was found to be more frequent in male (51.69%) compared to female (48.30%) with a male to female ratio of 1.1:1. Acute leukemia accounted for 66.95% of all leukemia case diagnosed, whereas chronic leukemia accounted for only 33.05% of the cases. The average, annual, age-standardized incidence rate of leukemia per 100,000 population was 2.30 (95% CI: 1.87-2.73). Conclusions: The incidence and pattern of leukemia in the Bhutanese population is similar to other published literature. Leukemia is not uncommon in the Bhutanese population, thus additional studies on risk factors for leukemia in the Bhutanese population is necessary.

scholarly journals Evaluation of the Effect of Cumulative Cisplatin Dose in Locoregionally Advanced Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

2019 ◽  
Author(s):  
Sheng-Chiao Lin ◽  
Yu-Hsuan Lin ◽  
Yaoh-Shiang Lin ◽  
Bor-Hwang Kang ◽  
Kuo-Ping Chang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cox Regression ◽  
Intensity Modulated Radiotherapy ◽  
Stage Iv ◽  
Survival Outcomes ◽  
Specific Patient ◽  
Female Ratio ◽  
Free Survival ◽  
Patient Groups ◽  
Male To Female

Abstract Background: In nasopharyngeal carcinoma (NPC), the cut-off value of cumulative cisplatin dose (CCD) associated with survival benefits remains controversial. This study aimed to determine a CCD cut-off value for favorable survival outcomes and to identify specific patient groups benefitting from higher CCDs. Methods: We retrospectively reviewed the records of 161 patients (male-to-female ratio of 2.6:1.0) with NPC receiving concurrent chemoradiotherapy ± adjuvant chemotherapy (AC) from February 2006 through September 2015 at our referral center. The CCD was calculated for each patient, and 3-year locoregional-free survival (LRFS), distant-metastasis free survival (DMFS), disease-specific survival (DSS), and overall survival (OS) were analyzed using a multivariable Cox regression model. Results: Stage N3 patients and stage IV patients had lower DMFS, DSS, and OS. A CCD ≥ 200 mg/m 2 or AC was not associated with survival benefits. After adjusting for other factors, N3 status remained robustly correlated with DMFS ( p < 0.001) and DSS ( p = 0.001). In subgroup analyses, stage N3 patients treated with CCD ≥ 200 mg/m 2 exhibited evident trends toward higher OS (one-sided p = 0.062), DSS (one-sided p = 0.100), DMFS (one-sided p = 0.059), and LRFS (one-sided p = 0.059) than patients treated with CCD < 200 mg/m 2 . Conclusions: A CCD ≥ 200 mg/m 2 might result in better survival outcomes in stage N3 patients. Larger CCDs may be exclusively used in cases of regionally advanced disease to avoid rigorous toxicity.

scholarly journals Risk factors for open conversion of laparoscopic biliary surgery

2018 ◽  
Vol 5 (3) ◽  
pp. 846
Author(s):  
Asem F. Mohammed ◽  
Moharm A. Abdelshahid ◽  
Mohammed A. Elbalshy
Keyword(s):  
Risk Factors ◽  
Open Approach ◽  
Surgical Experience ◽  
University Hospitals ◽  
Biliary Surgery ◽  
Female Ratio ◽  
Open Conversion ◽  
Conversion Rates ◽  
Co Morbidity ◽  
Male To Female

Background: Conversion rates of laparoscopic to open biliary procedures vary according to different factors such as clinical presentation, co-morbidity, surgical experience and equipment.Methods: A prospective analysis of 464 laparoscopic cholecystectomies (LC) including 88 laparoscopic common bile duct explorations (LCBDE) over a period of 5 years was carried out in Menofia University Hospitals, between December 2012 to December 2017.Results: The male to female ratio in the series was 1:3.4 with a Median±SD age 51±16 years.  158 cases (34%) of all patients were admitted as an emergency including jaundice in 60 cases (13%), acute pancreatitis in 27 cases 6% and acute cholecystitis/empyema in 27 cases (6%). 153 cases (33%) had previous abdominal surgery. LCBDE was done in 88 cases. open conversion was necessary in 6/464 cases (1.3%) over 5 years; with no conversions in the last 2 years (130 cases). converted cases had a Median±SD age 53±17 years and 67% were female.Conclusions: Several risk factors favour conversion from laparoscopic to an open approach in biliary surgeries that has to be identified preoperative to provide a better surgery.

scholarly journals Prevalence, Risk Factors, Awareness, and Treatment and Control of Hypertension in Mafia Island, Tanzania

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
M. S. Muhamedhussein ◽  
Z. I. Nagri ◽  
K. P. Manji
Keyword(s):  
Risk Factors ◽  
South Africa ◽  
Health Education ◽  
Descriptive Statistics ◽  
Female Ratio ◽  
High Prevalence ◽  
Receive Treatment ◽  
And Control ◽  
Male To Female

Introduction. The prevalence of hypertension in Africa ranges from 29.7% in Cameroon to 47% in South Africa. Only 10% receive treatment in Cameroon while 32% are on medications in Ghana. Control rates vary from 0.4% to 16.8%. This study was done to assess prevalence, risk factors, awareness, treatment, and control of hypertension in Mafia Island, Tanzania, which has never been documented before, so that necessary interventions can be undertaken accordingly.Methodology. Data was collected through questionnaires and anthropometric measurements were taken. Descriptive statistics were done and potential correlations were analyzed.Results. Out of 570 adults who were included in the study, 154 (27%) were aged 41–50 and the male-to-female ratio was 1 : 1.05. Almost half (49.5%) of the participants fit into the criteria of hypertension. Out of the 118 participants who were aware of having hypertension, 68 (57.6%) were currently taking medication. From those taking medication, only 14 (20.6%) had controlled hypertension.Conclusion. This study tried to show the extent of hypertension and find out risk factors which could explain the high prevalence of hypertension. This is very alarming and a dire need to raise awareness through health education, availability of screening, and treating and follow-up should be given priority.

scholarly journals Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

2012 ◽  
Vol 45 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Wilma Batista de Matos ◽  
Gisele Maria Campelo dos Santos ◽  
Vitor Emmanuel Bouças da Silva ◽  
Eloísa da Graça do Rosário Gonçalves ◽  
Antonio Rafael da Silva
Keyword(s):  
Rural Areas ◽  
Case Series ◽  
The State ◽  
Clinical Aspects ◽  
Direct Examination ◽  
Female Ratio ◽  
Central Regions ◽  
Clinical Description ◽  
Two Stages ◽  
Male To Female

INTRODUCTION: The study aimed to show the situation of paracoccidioidomycosis in the state of Maranhão, Brazil. METHODS: This study is a descriptive case series developed in two stages. First, a survey of cases originating from the state of Maranhão at the Instituto de Doenças Tropicais Natan Portela, Piauí (IDTNP) from 1997 to 2007, and second, the clinical description of 29 cases diagnosed in the Centro de Referências em Doenças Infecciosas e Parasitárias, Maranhão (CREDIP) from 2004 to 2010. RESULTS: Two hundred and sixteen cases have been cataloged at the IDTNP. West, east, and central regions of the state of Maranhão recorded 90.3% of cases proving to be important areas for study. The western region, with a prevalence of 10.8/100,000 inhabitants, has a significantly higher proportion of cases than the northern, southern, and eastern regions (p < 0.05). The occurrence was higher in men with 89.3% of cases, and the male-to-female ratio was 8.4:1. The majority of patients were older than 20 years, lived in rural areas, and had farming or soil management as main occupation (73.8%). At CREDIP, 29 cases were diagnosed, of which 26 (89.6%) had multifocal manifestations. Mucous tissues were involved more (75.8%) frequently, followed by lymph nodes, skin, and lungs with 65.5%, 39% and 37.9 %, respectively. The diagnosis was made by combining direct examination, culture, and histopathology. CONCLUSIONS: The study shows the geographical distribution and the epidemiological and clinical aspects of paracoccidioidomycosis, revealing the significance of the disease to the state of Maranhão.

scholarly journals Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan

2021 ◽  
Author(s):  
Wataru Ando ◽  
Masaki Takao ◽  
Tetsuro Tani ◽  
Keisuke Uemura ◽  
Hidetoshi Hamada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Head ◽  
Age Distribution ◽  
Female Ratio ◽  
Registry System ◽  
Registration Rate ◽  
The Mean ◽  
Associated Risk Factors ◽  
Epidemiological Characteristics ◽  
Male To Female

ABSTRACT Objectives Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database. Methods Data of patients with ONFH registered in the DID database between January 2004 and December 2013 were extracted. The incidence of new cases and distributions of sex, age, and associated risk factors were investigated. The prevalence of the two categories, ‘steroid-associated’ and ‘alcohol-associated’ risk factors, was estimated for each prefecture. Results New 15,049 cases of ONFH were investigated. The mean registration rate-corrected annual ONFH incidence per 100,000 individuals was 1.77. The male-to-female ratio was 1.33. Age distribution peaked in the 40s and 50s for male and 60s for female. The prevalence of steroid-associated ONFH was lower in males (28.6%) than in females (49.8%), while that of alcohol-associated ONFH was higher in males (47.2%) than in females (9.3%). No clear region was identified for the steroids. The incidence of alcohol-associated ONFH was significantly higher in Tokyo and Okinawa, regardless of sex. Conclusions Alcohol-associated ONFH incidence varies geographically across Japan, suggesting that it has regional characteristics.

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